The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Sex Differences in Pain
Abstract
Females greatly outnumber males as sufferers of chronic pain. Although social and psychological factors certainly play a role in the differences in prevalence and incidence, biological differences in the functioning of the immune system likely underlie these observed effects. This Review examines the current literature on biological sex differences in the functioning of the innate and adaptive immune systems as they relate to pain experience. With rodent models, we and others have observed that male mice utilize microglia in the spinal cord to mediate pain, whereas females preferentially use T cells in a similar manner. The difference can be traced to differences in cell populations, differences in suppression by hormones, and disparate cellular responses in males and females. These sex differences also translate into human cellular responses and may be the mechanism by which the disproportionate chronic pain experience is based. Recognition of the evidence underlying sex differences in pain will guide development of treatments and provide better options for patients that are tailored to their physiology. © 2016 Wiley Periodicals, Inc.
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Cites
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Sex, gender, and pain: a review of recent clinical and experimental findings
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Policy: NIH to balance sex in cell and animal studies
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Different immune cells mediate mechanical pain hypersensitivity in male and female mice
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Cited by
Physiology and Pathophysiology of Itch
Cevikbas, F., & Lerner, E. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 282
Pain in Women: A Perspective Review on a Relevant Clinical Issue that Deserves Prioritization
Casale, R., Atzeni, F., Bazzichi, L., Beretta, G., Costantini, E., Sacerdote, P., & Tassorelli, C. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00244-1 · Cited by 159
Boakye, P. A., Tang, S.-J., & Smith, P. A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.698157 · Cited by 102
Daily Fluctuations of Progesterone and Testosterone Are Associated With Fibromyalgia Pain Severity
Schertzinger, M., Wesson-Sides, K., Parkitny, L., & Younger, J. (2018) · The Journal of Pain · doi:10.1016/j.jpain.2017.11.013 · Cited by 79
Sex differences in pain responses
Sorge, R. E., & Strath, L. J. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.006 · Cited by 73
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Metadata
- Authors
- Sorge, R. E., & Totsch, S. K.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2016-07-25
- Volume
- 95
- Issue
- 6
- Pages
- 1271-1281
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2517358371
- Cited by
- 395
- References
- 19
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- closed
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