Senescent Microglia: The Key to the Ageing Brain?
Open accessAbstract
Ageing represents the single biggest risk factor for development of neurodegenerative disease. Despite being such long-lived cells, microglia have been relatively understudied for their role in the ageing process. Reliably identifying aged microglia has proven challenging, not least due to the diversity of cell populations, and the limitations of available models, further complicated by differences between human and rodent cells. Consequently, the literature contains multiple descriptions and categorisations of microglia with neurotoxic phenotypes, including senescence, without any unifying markers. The role of microglia in brain homeostasis, particularly iron storage and metabolism, may provide a key to reliable identification.
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The overlapping phenotypes of reactive and senescent microglia, together with heterogeneity of microglial phenotypes in aging and disease, present a challenge to defining senescent microglia and parsing their contribution to dysfunction.
“The overlapping phenotypes of reactive and senescent microglia together with the heterogeneity of microglial phenotypes described in aging and disease [45,46] present a nuanced challenge to defining senescent microglia and parsing out their contribution to dysfunction.”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [46]
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Linking the Meso and Macroscale Determinants of Cerebral AgeingPreprint
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Why resident microglial-like cells were missed in the peripheral nervous system
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Love in the Time of COVID: Psychiatric Outcomes Related to Oxytocin and the “Endocrine Organ”
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- Authors
- Greenwood, E. K., & Brown, D. R.
- Affiliations
- University of Bath (GB)
- Corresponding author
- Brown, David R.
- ORCID
- Brown, David R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-04-22
- Volume
- 22
- Issue
- 9
- Pages
- 4402
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8122783
- OpenAlex
- W3156112491
- Cited by
- 84
- References
- 209
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 19 · 2023: 17 · 2022: 9 · 2021: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, cellular senescence, brain aging, neurodegenerative diseases, iron metabolism, iron storage, microglial markers, brain homeostasis
- MeSH terms
- Aging, Animals, Humans, Cellular Senescence, Microglia, Neurodegenerative Diseases
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