Biomechanical and functional variation in rat sciatic nerve following cuff electrode implantation
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BACKGROUND: Nerve cuff electrodes are commonly and successfully used for stimulating peripheral nerves. On the other hand, they occasionally induce functional and morphological changes following chronic implantation, for reasons not always clear. We hypothesize that restriction of nerve mobility due to cuff implantation may alter nerve conduction. METHODS: We quantified acute changes in nerve-muscle electrophysiology, using electromyography, and nerve kinematics in anesthetized Sprague Dawley rat sciatic nerves during controlled hindlimb joint movement. We compared electrophysiological and biomechanical response in uncuffed nerves and those secured within a cuff electrode using analysis of variance (ANOVA) and regression analysis. RESULTS: Tethering resulting from cuff implantation resulted in altered nerve strain and a complex biomechanical environment during joint movement. Coincident with biomechanical changes, electromyography revealed significantly increased variability in the response of conduction latency and amplitude in cuffed, but not free, nerves following joint movement. CONCLUSION: Our findings emphasize the importance of the mechanical interface between peripheral nerves and their devices on neurophysiological performance. This work has implications for nerve device design, implantation, and prediction of long-term efficacy.
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These drawbacks may induce irreversible damage to the nerves and cause serious biological issues, including inflammation, demyelination, axonal degradation, and blood vein compression.
“These drawbacks may induce irreversible damage to the nerves and cause serious biological issues, including inflammation, demyelination, axonal degradation, and blood vein compression (14–17).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [14]
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Soft‐Actuated Cuff Electrodes with Minimal Contact for Bidirectional Peripheral Interfaces
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- Authors
- Restaino, S. M., Abliz, E., Wachrathit, K., Krauthamer, V., & Shah, S. B.
- Affiliations
- United States Food and Drug Administration (US)
- University of Maryland, College Park (US)
- Corresponding author
- Shah, Sameer B
- Venue
- Journal of NeuroEngineering and Rehabilitation
- Published
- 2014-04-23
- Volume
- 11
- Issue
- 1
- Pages
- 73-73
- ISSN
- 1743-0003 (ISSN-L)
- PMC
- PMC4022540
- OpenAlex
- W2161037068
- Cited by
- 44
- References
- 76
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of NeuroEngineering and Rehabilitation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University Libraries (University of Maryland) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Digital Repository at the University of Maryland (University of Maryland College Park)
- Funders
- National Science Foundation (1042522)
- U.S. Food and Drug Administration
- Division of Chemical, Bioengineering, Environmental, and Transport Systems
- Medical Research and Materiel Command (W81XWH1010773)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- cuff electrodes, sciatic nerve, peripheral nerve stimulation, nerve strain, chronic implantation, rat model
- MeSH terms
- Animals, Biomechanical Phenomena, Electrodes, Implanted, Electromyography, Electric Stimulation Therapy, Male, Sciatic Nerve, Rats, Sprague-Dawley, Rats
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