The Metabolic Impact on Histone Acetylation and Transcription in Ageing
Open accessAbstract
Loss of cellular homeostasis during aging results in altered tissue functions and leads to a general decline in fitness and, ultimately, death. As animals age, the control of gene expression, which is orchestrated by multiple epigenetic factors, degenerates. In parallel, metabolic activity and mitochondrial protein acetylation levels also change. These two hallmarks of aging are effectively linked through the accumulating evidence that histone acetylation patterns are susceptible to alterations in key metabolites such as acetyl-CoA and NAD(+), allowing chromatin to function as a sensor of cellular metabolism. In this review we discuss experimental data supporting these connections and provide a context for the possible medical and physiological relevance.
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Ubiquitination, sumoylation, O-GlcNAcylation, and ADP-ribosylation can have varying influences on transcriptional dysregulation.
“while post-translational modifications like ubiquitination, sumoylation, O-GlcNAcylation, and ADP-ribosylation, can have varying influences on transcriptional dysregulation (Pal and Tyler 2016, Peleg et al. 2016).”
From Benefits of Metformin in Attenuating the Hallmarks of Aging (2020) · cites this paper as Peleg et al. 2016
Histone acetylation and phosphorylation can lead to active transcription, loss of cellular homeostasis and age-associated metabolic decline.
“Histone modifications such as acetylation and phosphorylation can lead to active transcription, loss of cellular homeostasis and age-associated metabolic decline”
From Benefits of Metformin in Attenuating the Hallmarks of Aging (2020) · cites this paper as Peleg et al. 2016
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- Authors
- Peleg, S., Feller, C., Ladurner, A. G., & Imhof, A.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- ETH Zurich (CH)
- Center for Integrated Protein Science Munich (DE)
- Corresponding author
- Peleg, Shahaf
- Imhof, Axel
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 41
- Issue
- 8
- Pages
- 700-711
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2418484636
- Cited by
- 178
- References
- 130
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 13 · 2023: 21 · 2022: 22 · 2021: 23 · 2020: 18 · 2019: 27 · 2018: 11 · 2017: 16 · 2016: 5
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Trends in Biochemical Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- histone acetylation, aging, cellular metabolism, acetyl-CoA, NAD+, mitochondrial protein acetylation, epigenetic regulation, chromatin, gene expression, metabolic homeostasis
- MeSH terms
- Acetylation, Aging, Animals, Histones, Humans, Transcription, Genetic
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