The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel‐based morphometry
Abstract
Apathy is generally defined as a disorder of motivation and is considered one of the most common neuropsychiatric disturbances in Parkinson's disease (PD). Only few studies addressed the neuroanatomical correlates of apathy in PD. The aim of this article was to determine the structural correlates of apathy in PD patients. Fifty‐five PD patients underwent a neuropsychiatric and neuropsychological examination, and a 3 T magnetic resonance imaging scan was acquired. A voxel‐based multiple regression analysis was used to calculate correlation between gray matter density and severity measures of apathy. Apathy correlates with decreased cognitive functioning and more depressive symptoms but not with more severe motor symptoms. High apathy scores were correlated with low gray matter density values in a number of cortical brain areas: the bilateral precentral gyrus (BA 4, 6), the bilateral inferior parietal gyrus (BA 40), the bilateral inferior frontal gyrus (BA 44, 47), the bilateral insula (BA 13), the right (posterior) cingulate gyrus (BA 24, 30, 31), and the right precuneus (BA 31). Apathy in PD correlates with reduced gray matter density in a number of brain regions. The involvement of the cingulate gyrus and inferior frontal gyrus is in line with the results of earlier studies addressing apathy in patients with Alzheimer's disease or depressive disorder. Further studies addressing the pathogenesis of apathy are needed. © 2010 Movement Disorder Society.
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Cites
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“As the insula plays a role in subjective emotional experience, gray matter density loss in this area may be related to loss of spontaneous emotion or emotional responsiveness, which is one of the characteristics of apathy.(39,40) The parietal lobe plays an important role in integrating information from different sense…”
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Cited by
The anatomy of apathy: a neurocognitive framework for amotivated behaviour
Le Heron, C., Apps., M. A. J., & Husain, M. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.003 · Cited by 380
Stress, depression and Parkinson's disease
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Psychosis, apathy, depression and anxiety in Parkinson's disease
Gallagher, D. A., & Schrag, A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.041 · Cited by 211
Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy
Baggio, H. C., Segura, B., Garrido‐Millan, J. L., Marti, M., Compta, Y., Valldeoriola, F., Tolosa, E., & Junque, C. (2015) · Movement Disorders · doi:10.1002/mds.26137 · Cited by 131
Depression and impulse control disorders in Parkinson׳s disease: two sides of the same coin?
Vriend, C., Pattij, T., van der Werf, Y. D., Voorn, P., Booij, J., Rutten, S., Berendse, H. W., & van den Heuvel, O. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.001 · Cited by 106
Metadata
- Authors
- Reijnders, J. S. A. M., Scholtissen, B., Weber, W. E. J., Aalten, P., Verhey, F. R. J., & Leentjens, A. F. G.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2010-10-25
- Volume
- 25
- Issue
- 14
- Pages
- 2318-2325
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2071754987
- Cited by
- 200
- References
- 10
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reijnders, J. S. A. M., Scholtissen, B., Weber, W. E. J., Aalten, P., Verhey, F. R. J., & Leentjens, A. F. G. (2010). Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel‐based morphometry. Movement Disorders. https://doi.org/10.1002/mds.23268
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