The association between Mediterranean diet adherence and Parkinson's disease
Open accessAbstract
Background: Recent studies have demonstrated an association between a Mediterranean‐type diet and Alzheimer's risk. We assessed the association between Mediterranean‐type diet adherence and Parkinson's disease (PD) status. Methods: Two hundred and fifty‐seven PD participants and 198 controls completed the Willett semiquantitative questionnaire that quantifies diet during the past year. Scores were calculated using a 9‐point scale; higher scores indicated greater adherence to the Mediterranean‐type diet. Logistic regression models were used to assess the association between PD status and Mediterranean‐type diet, adjusting for caloric intake, age, sex, education, and ethnicity. Adjusted linear regression models were used to examine the association between Mediterranean‐type diet adherence and PD age at onset. Results: Higher Mediterranean‐type diet adherence was associated with reduced odds for PD after adjustment for all covariates (OR, 0.86; 95% CI, 0.77–0.97; P = .010). Lower Mediterranean‐type diet score was associated with earlier PD age at onset (β = 1.09; P = .006). Conclusions: PD patients adhere less than controls to a Mediterranean‐type diet. Dietary behavior may be associated with age at onset. © 2012 Movement Disorder Society
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Higher compliance with the Mediterranean diet is associated with lower risk of Parkinson's disease and lower score of the Mediterranean diet with earlier age of onset of Parkinson's disease, but it is not indicated whether low Mediterranean dietary compliance is the result or cause of Parkinson's disease.
“A case-control study reported that the higher the compliance with a Mediterranean diet, the lower the risk of Parkinson's disease and the lower the score of the Mediterranean diet, the earlier the age of onset of Parkinson's disease, but it did not indicate whether low Mediterranean dietary compliance was the result or cause of Parkinson's disease.236”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [236]
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- Authors
- Alcalay, R. N., Gu, Y., Mejia‐Santana, H., Cote, L., Marder, K. S., & Scarmeas, N.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Alcalay, Roy N.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2012-02-07
- Volume
- 27
- Issue
- 6
- Pages
- 771-774
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC3349773
- OpenAlex
- W2143891246
- Cited by
- 228
- References
- 39
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 16 · 2023: 23 · 2022: 32 · 2021: 17 · 2020: 21 · 2019: 19 · 2018: 16 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 4 · 2012: 2
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (AGO7232)
- National Institute on Aging (R01AG028506)
- National Institute of Neurological Disorders and Stroke (R01-NS32527, R01NS032527, R56NS036630, R01NS036630)
- National Institute of Environmental Health Sciences (P30ES009089)
- National Center for Research Resources (UL1RR024156, KL2RR024157)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Mediterranean diet, Parkinson's disease, dietary adherence, age of onset, dietary behavior, neurodegenerative disease risk, Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Energy Intake, Female, Humans, Male, Middle Aged, Parkinson Disease, Patient Compliance, Surveys and Questionnaires, Risk, Risk Factors, Body Mass Index, Case-Control Studies, Diet, Mediterranean
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