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Cited by 153Advanced Glycation End Products researchWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and Management

Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice

Peppa, Melpomeni, Brem, Harold, Ehrlich, Paul, Zhang, Jian-Gang, Cai, Weijing, Li, Zhu, Croitoru, Anca, Thung, Swan +1 more·2003·Diabetes
DOI 10.2337/diabetes.52.11.2805
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Abstract

Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-AGE] versus low [L-AGE] ratio, 5:1) for 3 months. Full-thickness skin wounds (1 cm) were examined histologically and for wound closure. Serum 24-h urine and skin samples were monitored for N(epsilon)-carboxymethyl-lysine and methylglyoxal derivatives by enzyme-linked immunosorbent assays. L-AGE-fed mice displayed more rapid wound closure at days 7 and 14 (P < 0.005) and were closed completely by day 21 compared with H-AGE nonhealed wounds. Serum AGE levels increased by 53% in H-AGE mice and decreased by 7.8% in L-AGE mice (P < 0.04) from baseline. L-AGE mice wounds exhibited lower skin AGE deposits, increased epithelialization, angiogenesis, inflammation, granulation tissue deposition, and enhanced collagen organization up to day 21, compared with H-AGE mice. Reepithelialization was the dominant mode of wound closure in H-AGE mice compared with wound contraction that prevailed in L-AGE mice. Thus, increased diet-derived AGE intake may be a significant retardant of wound closure in diabetic mice; dietary AGE restriction may improve impaired diabetic wound healing.

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  • Cytokine-induced SOCS1 and SOCS3 prevent tyrosine phosphorylation of IRS proteins by direct interference or ubiquitylation/degradation.

    “Another mechanism involves cytokine-induced suppressor of cytokine signalling 1 and 3, which also prevent tyrosine phosphorylation of IRS proteins, by direct interference, or ubiquitylation and subsequent degradation (130,131) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [130]

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Authors
Peppa, M., Brem, H., Ehrlich, P., Zhang, J.-G., Cai, W., Li, Z., Croitoru, A., Thung, S., & Vlassara, H.
Affiliations
  • Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York
  • Icahn School of Medicine at Mount Sinai (US)
  • Penn State Milton S. Hershey Medical Center (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2003-11-01
Volume
52
Issue
11
Pages
2805-2813
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.52.11.2805
OpenAlex
W2153488117
Cited by
153
References
50
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 8 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 14 · 2014: 6 · 2013: 12 · 2012: 12
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (60214, 59424)
  • National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords
dietary AGEs, diabetic wound healing, db/db mice, carboxymethyllysine, methylglyoxal, wound closure, re-epithelialization, angiogenesis, collagen organization, age limits
MeSH terms
Administration, Oral, Animals, Blood Glucose, Diabetes Mellitus, Diet, Mice, Mutant Strains, Skin, Wound Healing, Glycation End Products, Advanced, Mice

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