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Implications of apolipoprotein E genotype on inflammation and vitamin E status

Huebbe, Patricia, Lodge, John K., Rimbach, Gerald·2010·Molecular Nutrition & Food Research
DOI 10.1002/mnfr.200900398
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Abstract

In Western societies the apolipoprotein E4 (apoE4) genotype is associated with increased morbidity and mortality and represents a significant risk factor for cardiovascular and Alzheimer's disease. In a recent study we observed significantly lower tissue α‐tocopherol (α‐TOH) concentrations in apoE4 compared with apoE3 mice. Furthermore, genes encoding for proteins involved in peripheral α‐TOH transport and degradation were affected by the apoE genotype. Thus, the apoE4 genotype may be associated with lower vitamin E retention in peripheral tissues. This is possibly related to an altered lipoprotein metabolism including increased α‐TOH retention in LDL, a decreased expression of lipoprotein receptors and impaired cellular vitamin E delivery system, and a greater intracellular degradation of tocopherols in the apoE4 genotype. An increasing number of studies in cultured cells, transgenic mice and human volunteers indicate a more pro‐inflammatory state associated with the apoE4 allele. In apoE4 macrophages there is an enhanced transactivation of the key redox sensitive transcription factor NF‐κB accompanied by a higher production of pro‐inflammatory molecules (tumor necrosis factor α, interleukin 1β, macrophage inflammatory protein 1‐α) and a lower production of anti‐inflammatory interleukin 10, as compared with apoE3 macrophages. Both tissue vitamin E retention and biomarkers of chronic inflammation may be affected by the apoE genotype.

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  1. 10.1126/science.8346443 · DOI · Paper page
  2. 10.7326/0003-4819-141-2-200407200-00013 · DOI · Paper page
  3. 10.1001/jama.1997.03550160069041 · DOI · Paper page
  4. 10.1016/0003-9861(85)90704-0 · DOI
  5. 10.1016/S0021-9258(17)31797-0 · DOI · Paper page
  6. 10.1146/annurev.genom.1.1.507 · DOI · Paper page
  7. 10.1161/01.ATV.20.7.1807 · DOI
  8. Law M. R., 1994, By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?, Biomed. J, 308, 367
  9. 10.1002/mnfr.200700322 · DOI
  10. 10.1038/ng0996-55 · DOI · Paper page
  11. 10.1016/S0140-6736(01)05330-2 · DOI
  12. 10.1007/s11745-006-1390-4 · DOI
  13. 10.1111/j.1529-8817.2005.00205.x · DOI
  14. 10.1016/S0378-5122(01)00171-2 · DOI
  15. 10.1093/ajcn/81.1.95 · DOI
  16. 10.1017/S0007114507669219 · DOI
  17. 10.1016/j.bbrc.2007.03.150 · DOI
  18. 10.1006/exnr.1997.6750 · DOI · Paper page
  19. 10.1016/S0197-4580(00)00141-X · DOI
  20. 10.1016/S0891-5849(99)00102-1 · DOI
  21. 10.1006/nbdi.1999.0273 · DOI
  22. Huebbe P., 2007, Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice, J. Physiol. Pharmacol, 58, 683
  23. 10.1096/fj.05-5423fje · DOI
  24. 10.1186/1742-2094-3-21 · DOI
  25. 10.1074/jbc.M509042200 · DOI
  26. 10.1124/mol.107.043034 · DOI
  27. 10.1194/jlr.M700207-JLR200 · DOI
  28. 10.1172/JCI111883 · DOI
  29. 10.1196/annals.1331.034 · DOI
  30. 10.1194/jlr.M500143-JLR200 · DOI
  31. 10.1007/BF02536020 · DOI
  32. 10.1126/science.271.5248.518 · DOI · Paper page
  33. 10.1016/S1388-1981(00)00154-2 · DOI
  34. 10.1016/0167-4889(86)90193-X · DOI
  35. Witt W., 2000, Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells, J. Lipid Res, 41, 2009, 10.1016/S0022-2275(20)32362-2 · DOI
  36. 10.1093/jn/132.3.443 · DOI
  37. 10.1196/annals.1331.006 · DOI
  38. 10.1002/jnr.21037 · DOI
  39. 10.1016/j.bbadis.2007.04.006 · DOI
  40. 10.1046/j.1365-2362.2002.00983.x · DOI
  41. 10.1093/jn/137.12.2653 · DOI
  42. Fernandes M. A., 1999, Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients, Int. J. Mol. Med, 4, 179
  43. 10.1002/biof.5520180231 · DOI
  44. 10.1159/000090868 · DOI
  45. 10.1074/jbc.M201943200 · DOI
  46. 10.1016/j.jnutbio.2004.02.006 · DOI
  47. 10.1017/S000711450788634X · DOI
  48. 10.1002/iub.177 · DOI
  49. 10.1016/S0891-5849(01)00574-3 · DOI
  50. 10.1016/j.freeradbiomed.2006.06.022 · DOI
  51. 10.1016/j.freeradbiomed.2004.11.010 · DOI
  52. 10.1080/15216540400020346 · DOI
  53. 10.1161/01.CIR.102.1.82 · DOI
  54. 10.1016/S0006-2952(02)01520-4 · DOI
  55. 10.1080/15216540410001724133 · DOI
  56. 10.1074/jbc.270.45.27063 · DOI · Paper page
  57. 10.1017/S0007114508102434 · DOI
  58. Assmann G., 1984, Apolipoprotein E polymorphism and hyperlipidemia, Clin. Chem, 30, 641, 10.1093/clinchem/30.5.641 · DOI
  59. Boerwinkle E., 1988, Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism, Am. J. Hum. Genet., 42, 104

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Metadata

Authors
Huebbe, P., Lodge, J. K., & Rimbach, G.
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2010-05
Volume
54
Issue
5
Pages
623-630
ISSN
  • 1613-4125
  • 1613-4133
DOI
10.1002/mnfr.200900398
Cited by
43
References
9
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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