Protective effect of a pomace olive oil concentrated in triterpenic acids in alterations related to hypertension in rats: Mechanisms involved
Abstract
Scope: Despite the amount of information and research on the effects of virgin olive oil and its components in cardiovascular disease, little attention has been paid to the effects of pomace olive oil, an olive oil subproduct traditionally used in Spain. The aim of the present study was to evaluate the potential effects of a pomace olive oil concentrated in triterpenic acids (POCTA) on blood pressure, cardiac hemodynamics, and functional and molecular vascular alterations associated with hypertension in spontaneously hypertensive rats (SHR). Methods and results: The study showed that POCTA attenuated the increase of blood pressure in SHR. This effect was associated with an improvement in endothelium‐dependent relaxation, enhancement of vascular expression of endothelial nitric oxide synthase, and reduction of tumor necrosis factor alpha, transforming growth factor beta, and collagen I. Furthermore, POCTA improved cardiac hemodynamics (left ventricular systolic pressure and left ventricular end‐diastolic pressure) and decreased relative kidney and lung weights. Conclusion: POCTA exerts antihypertensive effects together with vascular and hypertension target organ protection in SHR. Since interest in pomace olive oil has been low, the results of this study contribute to increasing awareness of its biological and nutritional values.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous in vitro and preclinical studies with minor components of OPO have shown promising results on different cardiometabolic traits.
“Numerous in vitro and preclinical studies have been conducted with one or more of these so-called minor components of OPO, offering promising results on different cardiometabolic traits [7–9].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [7]
Previous assays have shown that triterpenes characteristic of OPO (OA and MA) modulate endothelial cell inflammation and suppress the production of inflammatory mediators such as TNFα and nuclear transcription factor kappa B (NF-κB) in in vivo and in vitro assays.
“Previous assays have shown that triterpenes characteristic of OPO (OA and MA) modulate endothelial cell inflammation and suppress the production of inflammatory mediators such as TNFα and nuclear transcription factor kappa B (NF-κB) in in vivo and in vitro assays [7, 8, 34, 39].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [7]
Several minor OPO components such as pentacyclic triterpenes (mainly OA), squalene or aliphatic alcohols (mainly octacosanol) have been associated with beneficial effects on blood pressure dysregulation.
“Several minor OPO components such as pentacyclic triterpenes (mainly OA), squalene or aliphatic alcohols (mainly octacosanol) have been associated with beneficial effects on blood pressure dysregulation [7, 35–37].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [7]
Previous animal studies have reported that OPO or its triterpene fraction (mainly OA) improve endothelial function in both aorta and mesenteric arteries by increasing eNOS expression.
“Previous animal studies have reported that OPO or its triterpene fraction (mainly OA) improve endothelial function in both aorta and mesenteric arteries by increasing eNOS expression [7].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [7]
These trials were carried out in lipopolysaccharide challenged endothelial cells or in animal models of different pathologies such as hypertension or obesity, involving inflammatory processes.
“These trials were carried out in lipopolysaccharide challenged endothelial cells [39] or in animal models of different pathologies such as hypertension [7] or obesity [8], involving inflammatory processes.”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [7]
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedΨαλτοπούλου, Θ., Naska, A., Orfanos, P., Trichopoulos, D., Mountokalakis, T. D., & Trichopoulou, A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1012 · Cited by 517 · see citing works
Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension
Miyamoto, Y., Saito, Y., Kajiyama, N., Yoshimura, M., Shimasaki, Y., Nakayama, M., Kamitani, S., Harada, M., Ishikawa, M., Kuwahara, K., et al. (1998) · Hypertension · doi:10.1161/01.hyp.32.1.3 · Cited by 517 · see citing works
Active components and clinical applications of olive oil.
Waterman, E., & Lockwood, B. (2007) · PubMed · Cited by 352 · see citing works
Panza, J. A., Casino, P. R., Badar, D. M., & Quyyumi, A. A. (1993) · Circulation · doi:10.1161/01.cir.87.5.1475 · Cited by 285 · see citing works
Moreno‐Luna, R., Múñoz‐Hernández, R., Miranda, M. L., Costa, A. F., Jiménez-Jiménez, L., Vallejo‐Vaz, A. J., Muriana, F. J. G., Villar, J. R., & Stiefel, P. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.128 · Cited by 243 · see citing works
Ramasamy, A., Kuokkanen, M., Vedantam, S., Gajdos, Z. K. Z., Alves, A. C., Lyon, H. N., Ferreira, M. A. R., Strachan, D. P., Zhao, J. H., Abramson, M. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044008 · Cited by 221 · see citing works
Bendinelli, B., Masala, G., Saieva, C., Salvini, S., Calonico, C., Sacerdote, C., Agnoli, C., Grioni, S., Frasca, G., Mattiello, A., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.000521 · Cited by 169 · see citing works
Vascular fibrosis in atherosclerosis
Lan, T.-H., Huang, X., & Tan, H. (2013) · Cardiovascular Pathology · doi:10.1016/j.carpath.2013.01.003 · Cited by 164 · see citing works
Endothelial function as a determinant of vascular function and structure: A new therapeutic target
Gibbons, G. H. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00122-7 · Cited by 162 · see citing works
Dietary factors associated with hypertension
Zhao, D. H., Qi, Y., Zheng, Z., Wang, Y., Zhang, X.-Y., Li, H.-J., Liu, H.-H., Zhang, X., Du, J., & Liu, J. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.75 · Cited by 155 · see citing works
Pro‐inflammatory cytokines in patients with essential hypertension
Peeters, A. C. T. M., Netea, M. G., Janssen, M. C. H., Kullberg, B. J., van der Meer, J. W. M., & Thien, T. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00743.x · Cited by 147 · see citing works
Anti-inflammatory Effects of Oleanolic Acid on LPS-Induced Inflammation In Vitro and In Vivo
Lee, W., Yang, E.-J., Ku, S.-K., Song, K.-S., & Bae, J.-S. (2013) · Inflammation · doi:10.1007/s10753-012-9523-9 · Cited by 145 · see citing works
Endothelium and growth factors in vascular remodeling of hypertension.
Dzau, V. J., & Gibbons, G. H. (1991) · Hypertension · doi:10.1161/01.hyp.18.5_suppl.iii115 · Cited by 142 · see citing works
Márquez-Martín, A., la Puerta, R. D., Fernández, Á., & Ruíz-Gutiérrez, V. (2006) · Free Radical Research · doi:10.1080/10715760500467935 · Cited by 127 · see citing works
Sanz‐Rosa, D., Oubiña, M. P., Cediel, E., Heras, N. D. L., Vegazo, O., Jiménez, J., Lahera, V., & Cachofeiro, V. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01061.2003 · Cited by 125 · see citing works
Self-citationMárquez-Martín, A., la Puerta, R. D., Fernández, Á., Ruíz-Gutiérrez, V., & Yaqoob, P. (2006) · Cytokine · doi:10.1016/j.cyto.2006.12.007 · Cited by 117 · see citing works
Vasculoprotective potential of olive oil components
Carluccio, M. A., Massaro, M., Scoditti, E., & Caterina, R. D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600305 · Cited by 114 · see citing works
Olive oil consumption and reduced incidence of hypertension: The SUN study
Alonso, Á., & Martínez‐González, M. Á. (2004) · Lipids · doi:10.1007/s11745-004-1352-x · Cited by 96 · see citing works
Rodríguez‐Rodríguez, R., Perona, J. S., Herrera, M. D., & Ruíz-Gutiérrez, V. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0528512 · Cited by 91 · see citing works
Sanz‐Rosa, D., Oubiña, M. P., Cediel, E., Heras, N. D. L., Aragoncillo, P., Balfagón, G., Cachofeiro, V., & Lahera, V. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1294 · Cited by 75 · see citing works
Self-citationRodríguez‐Rodríguez, R., Herrera, M. D., de Sotomayor, M. Á., & RUIZGUTIERREZ, V. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.012 · Cited by 71 · see citing works
Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs
Yang, E. J., Lee, W., Ku, S., Song, K., & Bae, J. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.026 · Cited by 70 · see citing works
Rodríguez‐Rodríguez, R., Stankevıčıus, E., Herrera, M. D., Østergaard, L., Andersen, M. R., Ruíz-Gutiérrez, V., & Simonsen, U. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.289 · Cited by 67 · see citing works
Molecular biology of hypertension.
Krieger, J. E., & Dzau, V. J. (1991) · Hypertension · doi:10.1161/01.hyp.18.3_suppl.i3 · Cited by 60 · see citing works
Oleanolic Acid Prevents Glucocorticoid‐induced Hypertension in Rats
Bachhav, S. S., Patil, S. D., Bhutada, M. S., & Surana, S. J. (2011) · Phytotherapy Research · doi:10.1002/ptr.3431 · Cited by 59 · see citing works
Novel approaches to improving endothelium-dependent nitric oxide-mediated vasodilatation
Simonsen, U., Rodríguez‐Rodríguez, R., Dalsgaard, T., Buus, N. H., & Stankevıčıus, E. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70012-x · Cited by 59 · see citing works
Maslinic Acid Protects Against Isoproterenol-Induced Cardiotoxicity in Albino Wistar Rats
Shaik, A. H., Rasool, S. N., Kareem, M. A., Krushna, G. S., Akhtar, P. M., & Devi, K. L. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2191 · Cited by 55 · see citing works
Cediel, E., Sanz‐Rosa, D., Oubiña, M. P., Heras, N. D. L., González‐Pacheco, F. R., Vegazo, O., Jiménez, J., Cachofeiro, V., & Lahera, V. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00643.2002 · Cited by 43 · see citing works
Self-citationN -Acetylcysteine Potentiates the Antihypertensive Effect of ACE Inhibitors in Hypertensive Patients
Barrios, V., Calderón, A., Navarro‐Cid, J., Lahera, V., & Ruilope, L. M. (2002) · Blood Pressure · doi:10.1080/08037050213760 · Cited by 40 · see citing works
Self-citationRodríguez‐Rodríguez, R., Herrera, M. D., de Sotomayor, M. Á., & Ruíz-Gutiérrez, V. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509990754 · Cited by 36 · see citing works
Vázquez-Pérez, S., Navarro‐Cid, J., Heras, N. D. L., Cediel, E., Sanz‐Rosa, D., Ruilope, L. M., Cachofeiro, V., & Lahera, V. (2001) · Journal of Hypertension · doi:10.1097/00004872-200103001-00004 · Cited by 34 · see citing works
Self-citationDIOL Triterpenes Block Profibrotic Effects of Angiotensin II and Protect from Cardiac Hypertrophy
Martín, R., Miana, M., Jurado-López, R., Martínez‐Martínez, E., Gómez‐Hurtado, N., Delgado, C., Bartolomé, M. V., Román, J. A. S., Córdova, C., Lahera, V., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041545 · Cited by 32 · see citing works
Self-citationMiana, M., Heras, N. D. L., Rodriguez, C., Sanz‐Rosa, D., Martín‐Fernández, B., Mezzano, S. A., Lahera, V., Martinez-Gonzalez, J., & Cachofeiro, V. (2011) · PubMed · Cited by 31 · see citing works
Self-citationHeras, N. D. L., Ruiz‐Ortega, M., Rupérez, M., Sanz‐Rosa, D., Miana, M., Aragoncillo, P., Mezzano, S. A., Lahera, V., Egido, J., & Cachofeiro, V. (2006) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2006.037 · Cited by 30 · see citing works
Self-citationMaeso, R., Navarro‐Cid, J., Rodrigo, E., Ruilope, L. M., Cachofeiro, V., & Lahera, V. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917020-00006 · Cited by 29 · see citing works
Self-citationMorillas, P., de Andrade, H., Castillo, J., Quiles, J., Bertomeu‐González, V., Cordero, A., Tarazón, E., Roselló, E., Portolés, M., Rivera, M., et al. (2012) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.03.020 · Cited by 28 · see citing works
Martín‐Fernández, B., Heras, N. D. L., Miana, M., Ballesteros, S., Valero‐Muñoz, M., Vassallo, D. V., Davel, A. P., Rossoni, L. V., Cachofeiro, V., & Lahera, V. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.063230 · Cited by 19 · see citing works
Self-citationHeras, N. D. L., Cediel, E., Oubiña, M. P., Aragoncillo, P., Sanz‐Rosa, D., Lahera, V., & Cachofeiro, V. (2003) · Clinical Science · doi:10.1042/cs20020199 · Cited by 17 · see citing works
Self-citationKim, H. Y., Cho, K. W., Kang, D. G., & Lee, H. S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.005 · Cited by 16 · see citing works
Miana, M., de las Heras, N., Rodriguez, C., Sanz-Rosa, D., Martín‐Fernández, B., Mezzano, S., Lahera, V., Martinez-Gonzalez, J., & Cachofeiro, V. (2011) · Americanae (AECID Library) · Cited by 11 · see citing works
Self-citationAn improved method of left ventricular catheterization in rats
Zhao, X., Wu, N., Deng, M., Yin, Y., Zhou, J., Fang, Y., & Huang, L. J. (2006) · Physiological Measurement · doi:10.1088/0967-3334/27/6/n01 · Cited by 10 · see citing works
Valero‐Muñoz, M., Martín‐Fernández, B., Ballesteros, S., Martínez‐Martínez, E., Blanco‐Rivero, J., Balfagón, G., Cachofeiro, V., Lahera, V., & Heras, N. D. L. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2012.070557 · Cited by 8 · see citing works
Self-citationLahera, V., & Cachofeiro, V. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.163 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Olive Fruit, Table Olives, and Olive Oil Bioactive Constituents
Boskou, D. G. (2015) · Elsevier eBooks · doi:10.1016/b978-1-63067-041-2.50007-0 · Cited by 101 · see citing works
Nutritional and other health properties of olive pomace oil
Mateos, R., Sarria, B., & Bravo, L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1698005 · Cited by 78 · see citing works
Sanchez-Rodriguez, E., Lima-Cabello, E., Biel-Glesson, S., Fernandez-Navarro, J. R., Calleja, M. A., Roca, M., Espejo-Calvo, J. A., Gil-Extremera, B., Soria-Florido, M., De la Torre, R., et al. (2018) · Nutrients · doi:10.3390/nu10050626 · Cited by 59 · see citing works
A review on management of cardiovascular diseases by olive polyphenols
Mehmood, A., Usman, M. A., Patil, P. J., Zhao, L., & Wang, C. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1668 · Cited by 58 · see citing works
de la Torre, R., Carbó, M., Pujadas, M., Biel, S., Mesa, M. D., Covas, M., Expósito, M., Espejo, J.-A., Sánchez-Rodríguez, E., Diaz‐Pellicer, P., et al. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126676 · Cited by 57 · see citing works
Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables
MONSALVE, B., Concha‐Meyer, A. A., Palomo, I. F., & Eduardo Fuentes, Q. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160509 · Cited by 51 · see citing works
Table Olives as Sources of Bioactive Compounds
Boskou, D. G., Camposeo, S., & Clodoveo, M. L. (2015) · Elsevier eBooks · doi:10.1016/b978-1-63067-041-2.50014-8 · Cited by 46 · see citing works
Broad-Spectrum Health Protection of Extra Virgin Olive Oil Compounds
Lombardo, L., Grasso, F., Lanciano, F., Loria, S., & Monetti, E. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64057-4.00002-8 · Cited by 43 · see citing works
Claro-Cala, C. M., Quintela, J. C., Pérez-Montero, M., Miñano, J., Alvarez de Sotomayor, M., Herrera, M. D., & Rodríguez-Rodríguez, R. (2020) · Nutrients · doi:10.3390/nu12020323 · Cited by 33 · see citing works
Self-citationClaro, C., Jiménez‐Altayó, F., Zagmutt, S., & Rodríguez‐Rodríguez, R. (2022) · Nutrients · doi:10.3390/nu14081606 · Cited by 34 · see citing works
Alcaide‐Hidalgo, J. M., Margalef, M., Bravo, F. I., Muguerza, B., & López‐Huertas, E. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.016 · Cited by 31 · see citing works
González-Rámila, S., Mateos, R., García-Cordero, J., Seguido, M. Á., Bravo, L., & Sarriá, B. (2022) · Foods · doi:10.3390/foods11152186 · Cited by 28 · see citing works
González-Rámila, S., Sarriá, B., Seguido, M. A., García-Cordero, J., Mateos, R., & Bravo, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03001-y · Cited by 24 · see citing works
“Previous assays have shown that triterpenes characteristic of OPO (OA and MA) modulate endothelial cell inflammation and suppress the production of inflammatory mediators such as TNFα and nuclear transcription factor kappa B (NF-κB) in in vivo and in vitro assays [7, 8, 34, 39].”
BackgroundIbarra-Lara, L., del Valle‐Mondragón, L., Soria‐Castro, E., Torres-Narváez, J. C., Pérez‐Severiano, F., Sánchez-Aguilar, M., Ramírez-Ortega, M. D. C., Cervantes-Pérez, L. G., Pastelín-Hernández, G. S., Oidor-Chan, V. H., et al. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.03.002 · Cited by 21 · see citing works
Boskou, D. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-376-8.00001-6 · Cited by 21 · see citing works
Effect of Olive Pomace Oil on Cardiovascular Health and Associated Pathologies
González-Rámila, S., Sarriá, B., Seguido, M. Á., García-Cordero, J., Bravo, L., & Mateos, R. (2022) · Nutrients · doi:10.3390/nu14193927 · Cited by 17 · see citing works
Panou, A., & Karabagias, I. K. (2025) · Beverages · doi:10.3390/beverages11030066 · Cited by 15 · see citing works
Table olive elicits antihypertensive activity in spontaneously hypertensive rats
Franco‐Ávila, T., Moreno‐González, R., Juan, M. E., & Planas, J. M. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12112 · Cited by 12 · see citing works
Papadaki, E., & Tsimidou, M. Z. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132286 · Cited by 10 · see citing works
Aispuro-Pérez, A., Pedraza-Leyva, F. J., Ochoa‐Acosta, D. A., Arias‐Gastélum, M., Cárdenas-Torres, F. I., Amézquita-López, B. A., Terán, E., Aispuro‐Hernández, E., Martínez‐Téllez, M. Á., Avena‐Bustillos, R. J., et al. (2025) · Foods · doi:10.3390/foods14081331 · Cited by 9 · see citing works
Li, J., Hu, G., Liu, W., Cao, X., Chen, G., Peng, F., Xie, X., & Peng, C. Y. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad032 · Cited by 9 · see citing works
Reyes‐Goya, C., Garrido, Á. S., Aguilar-Espejo, G., del Camino, M., Mate, A., & Vázquez, C. M. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522000034 · Cited by 9 · see citing works
Tuşat, M., Eröz, R., Bölükbaş, F., Ozkan, E. F., Demirtaş, M. S., Erdal, H., & Özocak, O. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320938 · Cited by 5 · see citing works
Physico‐chemical and rheological characterization of olive‐pomace oils
Sánchez‐Gutiérrez, C. A., Casas, M., Lucero, M. J., & Méndez, M. V. R. (2014) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201300490 · Cited by 4 · see citing works
Senent, F. R., Oria, A. B., Fernández‐Prior, Á., Lama‐Muñoz, A., Rodríguez‐Gutiérrez, G., & Fernández‐Bolaños, J. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70372 · Cited by 3 · see citing works
Milajerdi, A., Maghsoudi, Z., & Ghiasvand, R. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.010 · Cited by 4 · see citing works
Polyphenols and Triterpenes Combination in an In Vitro Model of Cardiac Damage: Protective Effects
Heras, N. D. L., Galiana, A., Ballesteros, S., Quintela, J. C., Bonilauri, I., Lahera, V., & Martín‐Fernández, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097977 · Cited by 1 · see citing works
Self-citationMechanisms Underlying the Antihypertensive and Vasodilatory Effects of Qingda Granules
Lahera, V. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000766
Self-citationGarba, M. S., & Bouderbala, S. (2022) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-220001
Maitra, S., Sethi, M., Inani, P., Shrivastava, P., Shriya, C., & Jacob, S. (2026) · doi:10.1002/9781394309955.ch6
Šajnová, M., Dussa, G., Harčárová, P., Lomozová, Z., Pour, M., Mladěnka, P., & Pourová, J. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107167
- Authors
- Valero‐Muñoz, M., Martín‐Fernández, B., Ballesteros, S., de la Fuente, E., Quintela, J. C., Lahera, V., & de las Heras, N.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Natac Biotech S.L Parque Científico de Madrid Campus de Cantoblanco Madrid Spain
- Department of Physiology School of Medicine, Universidad Complutense Madrid Spain
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2013-09-04
- Volume
- 58
- Issue
- 2
- Pages
- 376-383
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2080772572
- Cited by
- 31
- References
- 44
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 2 · 2022: 8 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- olive pomace oil, triterpenic acids, hypertension, antihypertensive effect, spontaneously hypertensive rats, endothelium-dependent relaxation, endothelial nitric oxide synthase, vascular inflammation, collagen deposition, cardiac hemodynamics, target organ protection, kidney, lung
- MeSH terms
- Olive Oil, Animals, Antihypertensive Agents, Blood Pressure, Heart, Hemodynamics, Hypertension, Male, Plant Oils, Rats, Inbred SHR, Spain, Triterpenes, Tumor Necrosis Factor-alpha, Transforming Growth Factor beta, Rats, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
