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Salic, K., Gart, E., Seidel, F., Verschuren, L., Caspers, M. P. M., van Duyvenvoorde, W., Wong, K. E., Keijer, J., Bobeldijk‐Pastorova, I., Wielinga, P. Y., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184359 · Cited by 47 · see citing works

Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise

Stocks, B., Ashcroft, S. P., Joanisse, S., Dansereau, L. C., Koay, Y. C., Elhassan, Y., Lavery, G. G., Quek, L., O’Sullivan, J., Philp, A. M., et al. (2021) · The Journal of Physiology · doi:10.1113/jp280825 · Cited by 43 · see citing works

Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside

Wang, Y.-J., Paneni, F., Stein, S., & Matter, C. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.755060 · Cited by 44 · see citing works

Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations

Cercillieux, A., Ciarlo, E., & Cantó, C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04499-5 · Cited by 41 · see citing works

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Biţă, A., Scorei, I. R., Ciocîlteu, M. V., Nicolaescu, O. E., Pîrvu, A. S., Bejenaru, L. E., Rău, G., Bejenaru, C., Radu, A., Neamţu, J., et al. (2023) · Molecules · doi:10.3390/molecules28166078 · Cited by 41 · see citing works

The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism

Fletcher, R. S., & Lavery, G. G. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0085 · Cited by 39 · see citing works

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

Dall, M., Trammell, S. A. J., Asping, M., Hassing, A. S., Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, S., & Treebak, J. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006756 · Cited by 40 · see citing works

High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet

Shi, W., Hegeman, M. A., Doncheva, A. I., Bekkenkamp‐Grovenstein, M., de Boer, V. C. J., & Keijer, J. (2019) · Nutrients · doi:10.3390/nu11102439 · Cited by 37 · see citing works

Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis–like phenotypes

Dall, M., Hassing, A. S., Niu, L., Nielsen, T. S., Ingerslev, L. R., Sulek, K., Trammell, S. A. J., Gillum, M. P., Barrès, R., Larsen, S., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101388 · Cited by 37 · see citing works

Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

Guarino, M., & Dufour, J. (2019) · Metabolites · doi:10.3390/metabo9090180 · Cited by 25 · see citing works

Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications

Benjamin, C., & Crews, R. (2024) · Metabolites · doi:10.3390/metabo14060341 · Cited by 23 · see citing works

Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors

Seldeen, K. L., Shahini, A., Thiyagarajan, R., Redae, Y. Z., Leiker, M. M., Rajabian, N., Dynka, A., Andreadis, S. T., & Troen, B. R. (2021) · Nutrition · doi:10.1016/j.nut.2021.111189 · Cited by 24 · see citing works

Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice

Escalante‐Covarrubias, Q., Mendoza-Viveros, L., González-Suárez, M., Sitten-Olea, R., Velázquez‐Villegas, L. A., Becerril-Pérez, F., Pacheco-Bernal, I., Carreño‐Vázquez, E., Sanchez, P. B. M., Bustamante-Zepeda, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37286-2 · Cited by 24 · see citing works

Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility

Franczyk, M. P., Qi, N., Stromsdorfer, K. L., Li, C., Yamaguchi, S., Itoh, H., Yoshino, M., Sasaki, Y., Brookheart, R. T., Finck, B. N., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab006 · Cited by 23 · see citing works

Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity

Cartwright, D. M., Oakey, L. A., Fletcher, R. S., Doig, C. L., Heising, S., Larner, D. P., Nasteska, D., Berry, C. E., Heaselgrave, S. R., Ludwig, C., et al. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0123 · Cited by 22 · see citing works

Meat Intake and the Dose of Vitamin B 3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

Hill, L. J., & Williams, A. C. (2017) · International Journal of Tryptophan Research · doi:10.1177/1178646917704662 · Cited by 23 · see citing works

NAD + repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation

Purhonen, J., Rajendran, J., Tegelberg, S., Smolander, O., Pirinen, E., Kallijärvi, J., & Fellman, V. (2018) · The FASEB Journal · doi:10.1096/fj.201800090r · Cited by 20 · see citing works

Nicotinamide riboside reduces cardiometabolic risk factors and modulates cardiac oxidative stress in obese Wistar rats under caloric restriction

de Castro, J. M., Assumpção, J. A. F., Stein, D. J., Ströher, R., da Silva, L. S., Caumo, W., Carraro, C. C., Araújo, A. S. D. R., & Torres, I. L. D. S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118596 · Cited by 19 · see citing works

Quantitation of NAD+: Why do we need to measure it?

Liu, Y., Clement, J., Grant, R., Sachdev, P. S., & Braidy, N. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.07.023 · Cited by 19 · see citing works

Synthesis of β‐Nicotinamide Riboside Using an Efficient Two‐Step Methodology

Zhang, N., & Sauve, A. A. (2017) · Current Protocols in Nucleic Acid Chemistry · doi:10.1002/cpnc.43 · Cited by 16 · see citing works

Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females

Panhuis, W. I. H., Tsaalbi‐Shtylik, A., Schönke, M., van Harmelen, V., Pronk, A. C. M., Streefland, T. C. M., Sips, H. C. M., Afkir, S., van Dijk, K. W., Rensen, P. C. N., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00357.2021 · Cited by 13 · see citing works

Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice

Lettieri‐Barbato, D., D’Angelo, F., Sciarretta, F., Tatulli, G., Tortolici, F., Ciriolo, M. R., & Aquilano, K. (2017) · Oncotarget · doi:10.18632/oncotarget.19948 · Cited by 14 · see citing works

The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance

Ruskovska, T., & Bernlohr, D. (2023) · Biomedicines · doi:10.3390/biomedicines11092560 · Cited by 13 · see citing works

Beyond Pellagra—Research Models and Strategies Addressing the Enduring Clinical Relevance of NAD Deficiency in Aging and Disease

Feuz, M. B., Meyer‐Ficca, M. L., & Meyer, R. G. (2023) · Cells · doi:10.3390/cells12030500 · Cited by 13 · see citing works

Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3

Shi, W., Hegeman, M. A., Doncheva, A. I., van der Stelt, I., Bekkenkamp‐Grovenstein, M., van Schothorst, E. M., Brenner, C., de Boer, V. C. J., & Keijer, J. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801100 · Cited by 8 · see citing works

The female mouse is resistant to mild vitamin B3 deficiency

van der Stelt, I., Shi, W., Bekkenkamp‐Grovenstein, M., Perez, R. Z., Houtkooper, R. H., de Boer, V. C. J., Hegeman, M. A., & Keijer, J. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02651-8 · Cited by 9 · see citing works

Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production

Nagy, L., Rauch, B., Szerafin, T., Uray, K., Tóth, A., & Bai, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.979330 · Cited by 8 · see citing works

Reduction of Obesity and Insulin Resistance through Dual Targeting of VAT and BAT by a Novel Combination of Metabolic Cofactors

Quesada‐Vázquez, S., Antolín, A., Colom‐Pellicer, M., Aragonès, G., Herrero, L., Bas-Prior, J. M. D., Caimari, A., & Escoté, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314923 · Cited by 7 · see citing works

Harnessing NAD+ Metabolism as Therapy for Cardiometabolic Diseases

Chakraborty, A. D., Minor, K. E., Nizami, H. L., Chiao, Y. A., & Lee, C. F. (2022) · Current Heart Failure Reports · doi:10.1007/s11897-022-00550-5 · Cited by 5 · see citing works

Short-term effects induced by nicotinamide in ovariectomized females

Lima, N. C. G. C., de Souza, S. A. R., Vieira, B. D. S., Rizzi, J. S., de Andrade, T. A. M., de Oliveira, C. A., & do Amaral, M. E. C. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0195 · Cited by 4 · see citing works

Impacts of 360 mg/kg Niacinamide Supplementation in Low-Protein Diets on Energy and Nitrogen Metabolism and Intestinal Microbiota in Growing–Finishing Pigs

Long, X., Wei, H., Wang, Z., Tang, Z., Xu, Y., Xie, P. P., Sun, Z., & Wu, L. (2025) · Animals · doi:10.3390/ani15142088 · Cited by 2 · see citing works

NAD + in fatty liver disease: mechanistic insights and associated targets

Guo, Y.-X., Wang, Y., Wu, S., Wang, Y., & Liu, X. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10106-7 · Cited by 3 · see citing works

Activation of Sirtuin 3, a Promising “Head Goose Molecule,” Triggers the Negentropic Mechanism for Treating Metabolic Diseases

Li, H., Wang, T., Dong, B., Peng, Z., & Jiang, J. (2025) · Engineering · doi:10.1016/j.eng.2025.12.008 · Cited by 2 · see citing works

The Divergent Effects of Nicotinamide Riboside and High‐Intensity Exercise Training on Skeletal Muscle Epigenetic Aging

Heikkinen, A., Uusitalo‐Kylmälä, L., Blom, I., Helge, J. W., Gillberg, L., Seaborne, R. A. E., Larsen, S., Jacques, M., Grolaux, R., Aaltonen, S., et al. (2026) · Aging Cell · doi:10.1111/acel.70638 · Cited by 2 · see citing works

Molecular physiological studies on health effects of dietary nicotinamide riboside, a vitamin B3

Shi, W. (2019) · doi:10.18174/471911 · Cited by 2 · see citing works

Time-of-day defines the efficacy of NAD + to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clockPreprint

Escalante‐Covarrubias, Q., Mendoza-Viveros, L., González-Suárez, M., Becerril-Pérez, F., Pacheco-Bernal, I., Carreño‐Vázquez, E., Sanchez, P. B. M., Bustamante-Zepeda, M., Orozco-Solís, R., & Aguilar‐Arnal, L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.12.503453 · Cited by 2 · see citing works

Effects of NAD⁺ repletion with Nicotinamide riboside on obesity-induced chronic kidney disease and renal cell lipotoxicity

Decarnoncle, M., Pierre, L., Thirion, M., Marlier, H., Maréchal, L., Rouzé, P., Jadot, I., Arnould, T., Declèves, A., & Juszczak, F. (2026) · Scientific Reports · doi:10.1038/s41598-026-46173-x · Cited by 1 · see citing works

Seneciphylline induces hepatotoxicity through mitochondrial apoptosis: mechanistic elucidation and in vitro-to-in vivo prediction via physiologically based pharmacokinetic modeling-facilitated reverse dosimetry

Lu, Y.-S., Ma, J., Geng, Y., Zhang, B.-Y., Ding, Z., Shi, X.-L., Xu, Y., Qiu, J., Qian, Y., Shi, W.-B., et al. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112016 · Cited by 1 · see citing works

Pharmacology of NAD+boosters

Braidy, N., & Sachdev, P. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00005-9 · Cited by 1 · see citing works

Modulação da concentração intracelular de NAD>SUP<+>/SUP< e seu efeito na tumorigênese induzida por benzo[>i/i<]pireno em células bronquiais epiteliais humanas

Cordeiro, E. W. F. (2021) · doi:10.11606/t.9.2021.tde-05082021-095853 · Cited by 1 · see citing works

Organoid based models to study the role of gut microbiota metabolites in post-weaning diarrhea

van der Hee, B. (2023) · doi:10.18174/630692 · Cited by 1 · see citing works

Vitamin B3 salvage and NAD\(^+\) metabolism in skeletal muscle

Fletcher, R. S. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)

Nutritional regulation of mitochondrial biogenic energy-sensing pathways in skeletal muscle following endurance exercise

Stocks, B. (2019) · University of Birmingham Institutional Research Archive (University of Birmingham)

Metabolic mapping of high-fit and low-fit individuals for human physiological health

Janssen, J. J. E. (2022) · doi:10.18174/573397

Fat burning capacity in a mixed macronutrient meal protocol does not reflect metabolic flexibility in women who are overweight or obesePreprint

Ahern, M. M., Artegoitia, V. M., Bosviel, R., Newman, J. W. I., Keim, N. L., & Krishnan, S. (2024) · medRxiv · doi:10.1101/2024.08.29.24312791

Acute Nicotinamide Adenine Dinucleotide Supplementation via Nicotinamide Mononucleotide Does Not Rescue Functional Impairment in a Lipopolysaccharide-induced Delirium Mouse Model

Chui, M. K. K., Kumaar, P. V. A., Schilling, B., Verdin, E., & Newman, J. C. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf116

Transcriptomic insights into the antidiabetic effects of mulberry leaf Fu brick tea in GK rats

Zhou, F., Ji-ming, J., Liu, Y., Liu, X.-Y., Tang, X.-Y., Qin, J., Fu, P.-Y., Ma, M.-Y., Fu, H., Zhu, B.-D., et al. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107212

Dual Effects of Nicotinamide on Aging‐Related Arrhythmia: Protective at Low Dose, Proarrhythmic at Higher Doses

Hu, L., Hu, Y., Qi, X., van Rinsum, A., Keijer, J., & Zhang, D. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.046761

High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet

Shi, W., Hegeman, M. A., Doncheva, A. I., Bekkenkamp‐Grovenstein, M., de Boer, V. C. J., & Keijer, J. (2019) · Nutrients · doi:10.3390/nu11102439 · Cited by 37 · see citing works

Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity

Cartwright, D. M., Oakey, L. A., Fletcher, R. S., Doig, C. L., Heising, S., Larner, D. P., Nasteska, D., Berry, C. E., Heaselgrave, S. R., Ludwig, C., et al. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0123 · Cited by 22 · see citing works

Nicotinamide riboside supplementation exerts an anti–obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice

Kim, M., Pham, T. X., vanLuling, M., Kostour, V., Kang, H., Corvino, O., Jang, H., Odell, W., Bae, M., Park, Y., et al. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109058 · Cited by 21 · see citing works

Molecular physiological studies on health effects of dietary nicotinamide riboside, a vitamin B3

Shi, W. (2019) · doi:10.18174/471911 · Cited by 2 · see citing works

Nicotinamide Riboside Supplementation Attenuates Obesity-Induced Adipose Tissue Fibrosis and Inflammation in Female Mouse Model

Kim, M., Pham, T. X., vanLuling, M., Kostour, V., Kang, H., Corvino, O., Jang, H., Odell, W., Park, Y., & Lee, J. (2022) · Current Developments in Nutrition · doi:10.1093/cdn/nzac053.041