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Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity
Open accessAbstract
Scope: To examine the potential relationship among gene expression markers of adipose tissue browning, gut microbiota, and insulin sensitivity in humans. Methods and results: Gut microbiota composition and gene markers of browning are analyzed in subcutaneous (SAT) and visceral (VAT) adipose tissue from morbidly obese subjects (n = 34). Plasma acetate is measured through 1 H NMR and insulin sensitivity using euglycemic hyperinsulinemic clamp. Subjects with insulin resistance show an increase in the relative abundance (RA) of the phyla Bacteroidetes and Proteobacteria while RA of Firmicutes is decreased. In all subjects, Firmicutes RA is negatively correlated with HbA 1c and fasting triglycerides, whereas Proteobacteria RA was negatively correlated with insulin sensitivity. Firmicutes RA is positively associated with markers of brown adipocytes (PRDM16, UCP1, and DIO2) in SAT, but not in VAT. Multivariate regression analysis indicates that Firmicutes RA contributes significantly to SAT PRDM16, UCP1, and DIO2 mRNA variance after controlling for age, BMI, HbA 1c, or insulin sensitivity. Interestingly, Firmicutes RA, specifically those bacteria belonging to the Ruminococcaceae family, is positively associated with plasma acetate levels, which are also linked to SAT PRDM16 mRNA and insulin sensitivity. Conclusion: Gut microbiota composition is linked to adipose tissue browning and insulin action in morbidly obese subjects, possibly through circulating acetate.
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“In addition, gut microbiota also seems to play an important role as a regulator of WAT browning.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [247]
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“In some obese insulin-sensitive patients, a decreased level in Firmicutes is associated with the downregulation of WAT browning.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [247]
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“Interestingly, the Firmicutes level was found to be directly correlated with PRDM16 mRNA expression (a key transcription factor involved in BAT differentiation) and UCP-1 expression in subcutaneous and visceral WAT [247].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [247]
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“Interestingly, the Firmicutes level was found to be directly correlated with PRDM16 mRNA expression (a key transcription factor involved in BAT differentiation) and UCP-1 expression in subcutaneous and visceral WAT [247].”
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Metadata
- Authors
- Moreno‐Navarrete, J. M., Serino, M., Blasco‐Baque, V., Azalbert, V., Barton, R. H., Cardellini, M., Latorre, J., Ortega, F., Sabater‐Masdeu, M., Burcelin, R., Dumas, M., Ricart, W., Federici, M., & Fernández‐Real, J. M.
- Affiliations
- Universitat de Girona (ES)
- Institut National de la Santé et de la Recherche Médicale (Inserm) Toulouse France
- Inserm (FR)
- Imperial College London (GB)
- University of Rome Tor Vergata (IT)
- Instituto de Salud Carlos III (ES)
- Department of Diabetes, Endocrinology and Nutrition Institut d'Investigació Biomèdica de Girona (IdIBGi) CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII) Girona Spain
- Corresponding author
- Moreno‐Navarrete, José María
- Fernández‐Real, José Manuel
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2017-12-29
- Volume
- 62
- Issue
- 3
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2766183128
- Cited by
- 106
- References
- 45
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 12 · 2018: 5
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- green
- hal.inrae.fr
- Licence
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Instituto de Salud Carlos III (PI15/01934)
- European Regional Development Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, adipose tissue browning, brown adipocytes, insulin sensitivity, insulin resistance, morbid obesity, subcutaneous adipose tissue, visceral adipose tissue, plasma acetate, Firmicutes, Ruminococcaceae, PRDM16, UCP1, DIO2, Bacteroidetes, Proteobacteria, HbA1c, fasting triglycerides
- MeSH terms
- Gastrointestinal Microbiome, Uncoupling Protein 1, Acetates, Iodothyronine Deiodinase Type II, Adipose Tissue, Adult, DNA-Binding Proteins, Female, Humans, Insulin Resistance, Iodide Peroxidase, Male, Middle Aged, Obesity, Morbid, Transcription Factors, Biomarkers, Glucose Transporter Type 4, Adipose Tissue, White, Insulin Receptor Substrate Proteins
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