The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes
Open accessAbstract
The gut microbiota has been linked to metabolic diseases. However, information on the microbiome of young adults at risk for type 2 diabetes (T2D) is lacking. The aim of this cross-sectional analysis was to investigate whether insulin resistant women with previous gestational diabetes (pGDM), a high risk group for T2D, differ in their stool microbiota from women after a normoglycemic pregnancy (controls). Bacterial communities were analyzed by high-throughput 16S rRNA gene sequencing using fecal samples from 42 pGDM and 35 control subjects 3–16 months after delivery. Clinical characterization included a 5-point OGTT, anthropometrics, clinical chemistry markers and a food frequency questionnaire. Women with a Prevotellaceae-dominated intestinal microbiome were overrepresented in the pGDM group (p < 0.0001). Additionally, the relative abundance of the phylum Firmicutes was significantly lower in women pGDM (median 48.5 vs. 56.8%; p = 0.013). Taxa richness (alpha diversity) was similar between the two groups and with correction for multiple testing we observed no significant differences on lower taxonomic levels. These results suggest that distinctive features of the intestinal microbiota are already present in young adults at risk for T2D and that further investigations of a potential pathophysiological role of gut bacteria in early T2D development are warranted.
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A study of stool bacteria in women with a past case of GDM reported a lower proportion of the phylum Firmicutes and higher proportion of the family Prevotellaceae as compared with normoglycemic pregnancy.
“Furthermore, a study of stool bacteria in women with a past case of GDM reported a lower proportion of the phylum Firmicutes and higher proportion of the family Prevotellaceae as compared with normoglycemic pregnancy [128].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [128]
The Results section reports significantly lower Firmicutes abundance in women post-GDM than in controls after a normoglycemic pregnancy. It also reports that a Prevotellaceae-rich subgroup was overrepresented among women post-GDM, but found no significant family-level difference between the two study groups after correction for multiple testing. Thus, the claim overstates the Prevotellaceae finding as a group-wide difference in proportion. (LLM, conf=0.88)
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The Pathophysiology of Gestational Diabetes Mellitus
Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113342 · Cited by 1,874 · see citing works
“(2015) remained after adjustment for dietary habits [128].”
BackgroundResultInfluentialMoreno‐Navarrete, J. M., Serino, M., Blasco‐Baque, V., Azalbert, V., Barton, R. H., Cardellini, M., Latorre, J., Ortega, F., Sabater‐Masdeu, M., Burcelin, R., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700721 · Cited by 106 · see citing works
- Authors
- Fugmann, M., Breier, M., Rottenkolber, M., Banning, F., Ferrari, U., Sacco, V., Grallert, H., Parhofer, K. G., Seissler, J., Clavel, T., & Lechner, A.
- Affiliations
- Helmholtz Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- LMU Klinikum (DE)
- Technical University of Munich (DE)
- Corresponding author
- Lechner, Andreas
- ORCID
- Venue
- Scientific Reports
- Published
- 2015-08-17
- Volume
- 5
- Issue
- 1
- Pages
- 13212-13212
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4538691
- OpenAlex
- W2396020709
- Cited by
- 131
- References
- 12
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 18 · 2021: 23 · 2020: 12 · 2019: 13 · 2018: 11 · 2017: 13 · 2016: 5
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Site cant be reached (submittedVersion, cc-by)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
- Funders
- Ludwig-Maximilians-Universität München
- Helmholtz Zentrum München
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, gestational diabetes mellitus, type 2 diabetes risk, insulin resistance, Prevotellaceae, Firmicutes, fecal microbiota, young women, postpartum women, alpha diversity, dysbiosis
- MeSH terms
- Bacillota, Firmicutes, Adult, Cross-Sectional Studies, Demography, Diabetes Mellitus, Type 2, Feces, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Intestines, Pregnancy, Risk Factors, RNA, Ribosomal, 16S, Diabetes, Gestational, Sequence Analysis, DNA, Actinobacteria, Bacteroidetes, Young Adult, Microbiota
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