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Cited by 331Gut microbiota and healthRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

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Canfora, Emanuel E., van der Beek, Christina M., Jocken, Johan W. E., Goossens, Gijs H., Holst, Jens J., Olde Damink, Steven W. M., Lenaerts, Kaatje, Dejong, Cornelis H. C. +1 more·2017·Scientific Reports
DOI 10.1038/s41598-017-02546-xPMC PMC5443817
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Abstract

Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m 2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.

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  • Acute rectal infusions of sodium acetate and SCFA mixtures increased circulating concentrations of PYY in overweight individuals.

    “Although limited, some of these results were confirmed in human in vivo studies, as showed that acute rectal infusions of sodium acetate and SCFA mixtures increased circulating concentrations of PYY in individuals who were overweight (197–199).”

    From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [199]

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Authors
Canfora, E. E., van der Beek, C. M., Jocken, J. W. E., Goossens, G. H., Holst, J. J., Olde Damink, S. W. M., Lenaerts, K., Dejong, C. H. C., & Blaak, E. E.
Affiliations
  • Maastricht University Medical Centre (NL)
  • University of Copenhagen (DK)
Corresponding author
Canfora, Emanuel E.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-05-24
Volume
7
Issue
1
Pages
2360-2360
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-02546-x
PMC
PMC5443817
OpenAlex
W2614800736
Cited by
331
References
7
Citations by year
2026: 26 · 2025: 42 · 2024: 45 · 2023: 37 · 2022: 43 · 2021: 48 · 2020: 36 · 2019: 32 · 2018: 16 · 2017: 5
FWCI
9.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders
Universiteit Maastricht
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
short-chain fatty acids, acetate, propionate, butyrate, energy metabolism, resting energy expenditure, fat oxidation, lipolysis, peptide YY, free glycerol, obesity, overweight men, gut microbiota fermentation, insulin resistance
MeSH terms
Adult, Colon, Double-Blind Method, Energy Metabolism, Fasting, Fats, Fatty Acids, Volatile, Humans, Infusions, Parenteral, Male, Obesity, Oxidation-Reduction, Propionates, Cross-Over Studies, Acetic Acid, Postprandial Period, Butyric Acid, Overweight

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