Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
Abstract
We have reported that orally administrated acetate contributed to suppression of lipogenesis in the liver and to reduction of lipid accumulation in the adipose tissue of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The aim of this study was to investigate the effect of acetate on skeletal muscle and adipose tissues. Treatment with acetate showed a higher rate of oxygen consumption and a smaller size of lipid droplets in white adipose and brown adipose tissues. An analysis by Northern blotting revealed that the transcripts of myoglobin and Glut4 genes in the abdominal muscle of the OLETF rats were increased by acetate treatment, while the transcripts of lipolytic genes increased in the white adipose and brown adipose tissues. It is possible that acetate has effects on lipid metabolism in the skeletal muscles and the adipose tissues, and has functions that work against obesity and obesity-linked type 2 diabetes.
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- Authors
- YAMASHITA, H., MARUTA, H., JOZUKA, M., KIMURA, R., IWABUCHI, H., YAMATO, M., SAITO, T., FUJISAWA, K., TAKAHASHI, Y., KIMOTO, M., HIEMORI, M., & TSUJI, H.
- Affiliations
- Okayama Prefectural University (JP)
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2009-03-23
- Volume
- 73
- Issue
- 3
- Pages
- 570-576
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2045529411
- Cited by
- 146
- References
- 4
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 22 · 2023: 14 · 2022: 21 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 4 · 2012: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- acetate, lipid metabolism, type 2 diabetes, OLETF rats, skeletal muscle, adipose tissue, brown adipose tissue, white adipose tissue, lipid droplets, oxygen consumption, myoglobin, GLUT4, lipolysis, obesity
- MeSH terms
- Abdominal Muscles, Acetates, Adenosine Monophosphate, Adenosine Triphosphate, Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Energy Metabolism, Gene Expression Regulation, Male, Myoglobin, Oxygen, Phosphorylation, RNA, Messenger, Muscle, Skeletal, Rats, Inbred OLETF, Lipid Metabolism, Glucose Transporter Type 4, Rats, Adipocytes, Brown, Adipocytes, White, AMP-Activated Protein Kinases
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