Gut Microbiota Orchestrates Energy Homeostasis during Cold
Open accessAbstract
Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host and enable tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold, however, the body weight loss is attenuated, caused by adaptive mechanisms maximizing caloric uptake and increasing intestinal, villi, and microvilli lengths. This increased absorptive surface is transferable with the cold microbiota, leading to altered intestinal gene expression promoting tissue remodeling and suppression of apoptosis-the effect diminished by co-transplanting the most cold-downregulated strain Akkermansia muciniphila during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.
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Cold exposure impacts gut microbiota composition in mice by increasing the Firmicutes level.
“Finally, cold exposure also impacts gut microbiota composition in mice, again by increasing the Firmicutes level [250].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [250]
Gut microbiota regulates whole‐body energy homeostasis in response to cold, nutrition, or fasting/feeding cycles through the production of SCFAs and secondary BAs.
“Furthermore, gut microbiota has been described in the past two decades as a very important player in the regulation of whole‐body energy homeostasis, in response to diverse stimuli such as cold 165, 166, nutrition 167, 168, or fasting/feeding cycles 168, 169, 170, through the production of mediators such as short chain fatty acids (SCFAs) and secondary BAs 167, 169.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [165]
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- Authors
- Chevalier, C., Stojanović, O., Colin, D. J., Suarez-Zamorano, N., Tarallo, V., Veyrat-Durebex, C., Rigo, D., Fabbiano, S., Stevanović, A., Hagemann, S., Montet, X., Seimbille, Y., Zamboni, N., Hapfelmeier, S., & Trajkovski, M.
- Affiliations
- University of Geneva (CH)
- University Hospital of Geneva (CH)
- University of Bern (CH)
- ETH Zurich (CH)
- Corresponding author
- Trajkovski, Mirko
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 163
- Issue
- 6
- Pages
- 1360-1374
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2181471414
- Cited by
- 829
- References
- 37
- Citations by year
- 2026: 52 · 2025: 82 · 2024: 91 · 2023: 97 · 2022: 110 · 2021: 91 · 2020: 97 · 2019: 66 · 2018: 51 · 2017: 47 · 2016: 40 · 2015: 2
- FWCI
- 20.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- Novartis Foundation (14B053)
- Seventh Framework Programme (336607, ERC-2013-StG-336607, FP/2007-2013)
- European Research Council
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP00P3_144886)
- Fondation pour la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, cold exposure, energy homeostasis, microbiota transplantation, germ-free mice, insulin sensitivity, white adipose tissue browning, energy expenditure, fat loss, intestinal gene expression, Akkermansia muciniphila
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cold Temperature, Energy Metabolism, Germ-Free Life, Homeostasis, Insulin Resistance, Intestinal Absorption, Apoptosis, Enterocytes, Gastrointestinal Tract, Mice, Adipose Tissue, White, Verrucomicrobia
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