The gut microbiota in human energy homeostasis and obesity
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Numerous studies of rodents suggest that the gut microbiota populations are sensitive to genetic and environmental influences, and can produce or influence afferent signals that directly or indirectly impinge on energy homeostatic systems affecting both energy balance (weight gain or loss) and energy stores. Fecal transplants from obese and lean human, and from mouse donors to gnotobiotic mice, result in adoption of the donor somatotype by the formerly germ-free rodents. Thus, the microbiota is certainly implicated in the development of obesity, adiposity-related comorbidities, and the response to interventions designed to achieve sustained weight reduction in mice. More studies are needed to determine whether the microbiota plays a similarly potent role in human body-weight regulation and obesity.
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In humans, when comparing obese and lean individuals, both gut microbiota diversity and the ratio of Bacteroidetes to Firmicutes are decreased in obese individuals.
“Generally, when comparing obese and lean individuals, both the diversity of the gut microbiota and the ratio of Bacteroidetes to Firmicutes is decreased in obese individuals [145].”
From The athletic gut microbiota (2020) · cites this paper as [145]
The gut microbiota plays an important role in energy extraction and can be influenced by the composition of the diet and the amount of energy entering this environment.
“the gut microbiota plays an important role in energy extraction and, in turn, can be influenced by the composition of the diet and the amount of energy entering this environment [145].”
From The athletic gut microbiota (2020) · cites this paper as [145]
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Flagged first, then by citations
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BackgroundWhy does the microbiome affect behaviour?
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- Authors
- Rosenbaum, M., Knight, R., & Leibel, R. L.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of California San Diego (US)
- Columbia University (US)
- Corresponding author
- Rosenbaum, Michael
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 26
- Issue
- 9
- Pages
- 493-501
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4862197
- OpenAlex
- W2138330280
- Cited by
- 450
- References
- 98
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 25 · 2023: 34 · 2022: 57 · 2021: 57 · 2020: 58 · 2019: 58 · 2018: 41 · 2017: 39 · 2016: 34 · 2015: 5
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000040)
- National Human Genome Research Institute (R01HG004872, HG4872)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK030292, DK-30292, DK078669, P01DK078669, DK 70977, DK64774, R01DK070977, P30DK026687, R01DK030292)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, energy homeostasis, obesity, energy balance, weight gain, weight loss, fecal microbiota transplantation, gnotobiotic mice, germ-free mice, body weight regulation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Energy Metabolism, Humans, Obesity, Adiposity
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