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Identification of vascular structures as a major source of signal contrast in high resolution 2D and 3D functional activation imaging of the motor cortex at l.5T preliminary results
Abstract
We have measured the T2* signal response associated with cortical activation due to finger motion at 1.5 Tesla. Both thin slice 2D and 3D images show signal intensity changes which vary from 2% to 32% depending on volunteer, echo time, slice thickness, and in‐plane resolution. The largest signal change occurred for the thinnest slices and highest resolution (2 mm 3). This is consistent with reducing partial volume effects and a simple difference in phase between the intravascular signal and surrounding parenchyma. No inflow enhancement was seen on the 2D or 3D scans, confirming the nature of the signal difference for this approach was due to local field in‐homogeneity effects. Using 3D imaging, multiple effects can be seen simultaneously. With a 3D MRA method, it was possible to locate the vessel that was the source of the T2* behavior; it was in each case a vein on the surface of the cortical parenchyma.
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“Indeed, activity in the AIC is a common feature in studies of cognitive control and inhibitory processing [7, 46–50] and reward sensitivity [8, 9].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [50]
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Hoogenraad, F. G. C., Reichenbach, J. R., Haacke, E. M., Lai, S., Kuppusamy, K., & Sprenger, M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390116 · Cited by 85
Self-citation
Metadata
- Authors
- Lai, S., Hopkins, A. L., Haacke, E. M., Li, D., Wasserman, B. A., Buckley, P., Friedman, L., Meltzer, H., Hedera, P., & Friedland, R.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Haacke, E. M.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1993-09
- Volume
- 30
- Issue
- 3
- Pages
- 387-392
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2013713875
- Cited by
- 390
- References
- 12
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 3 · 2012: 13
- FWCI
- 27.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (NIA AG08012)
- National Institute of Mental Health (NIMH 41684)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- vascular architecture, motor cortex activation, finger movement, 1.5 Tesla, partial volume effect, cerebral veins, cerebral blood volume, three-dimensional MR angiography
- MeSH terms
- Brain, Cerebrovascular Circulation, Fingers, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Motor Cortex, Movement, Signal Processing, Computer-Assisted, Time Factors
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