The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man
Abstract
Changes in glucose consumption, lactate production, and blood oxygenation were measured during prolonged neuronal activation (4–6 min) in human primary visual cortex using dynamic magnetic resonance spectroscopy and imaging. A decrease of steady‐state glucose by 40% because of enhanced use by 21% was accompanied by a transient accumulation of lactate with a peak value of 170% 2.5 min after stimulation onset Rapid blood hyperoxygenation indicating „uncoupling”︁ of blood flow and oxidative metabolism was followed by a return to basal levels over 3 min. Thus, initial nonoxidative glucose consumption during functional activation is gradually complemented by a slower adjustment of oxidative phosphorylation that „recouples”︁ perfusion and oxygen consumption at a new equilibrium.
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Cites
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Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
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Time course EPI of human brain function during task activation
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Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Cited by
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model
Buxton, R. B., Wong, E. C., & Frank, L. R. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390602 · Cited by 1,665
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Logothetis, N. K., & Wandell, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.082602.092845 · Cited by 1,568
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153
Metadata
- Authors
- Frahm, J., Krüger, G., Merboldt, K., & Kleinschmidt, A.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1996-02
- Volume
- 35
- Issue
- 2
- Pages
- 143-148
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2042873520
- Cited by
- 327
- References
- 6
- FWCI
- 22.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frahm, J., Krüger, G., Merboldt, K., & Kleinschmidt, A. (1996). Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910350202
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
