CoChat
Sign Up
Cited by 113Treatment of Major DepressionDementia and Cognitive Impairment ResearchNeural and Behavioral Psychology Studies

Pattern of brain atrophy in elderly patients with depression revealed by voxel-based morphometry

Egger, Karl, Schocke, Michael, Weiss, Elisabeth, Auffinger, Simone, Esterhammer, Regina, Goebel, Georg, Walch, Thomas, Mechtcheriakov, Sergei +1 more·2008·Psychiatry Research Neuroimaging
DOI 10.1016/j.pscychresns.2007.12.018
Open this paper in CoChat — free account

Abstract

In this study, we explored to what extent brain abnormalities can be identified in specific brain structures of patients suffering from late onset depression. We examined the structural difference in regional gray and white matter volume between 14 community-dwelling patients suffering from geriatric depression and 20 age-matched non-depressed normal subjects by voxel-based morphometry (VBM) based on magnetic resonance imaging. All subjects also underwent an extensive neuropsychological assessment. Compared with control subjects, patients with depression were impaired in measures of verbal and visual memory, construction, executive ability, and information-processing speed. VBM of gray matter revealed a significant decrease of volume in the right rostral hippocampus, in the right amygdala and in the medial orbito-frontal cortex (gyrus rectus) bilaterally. In the correlation analysis of gray matter volume with the score of the geriatric depression scale, we observed a negative correlation with the medial orbito-frontal cortex (gyrus rectus) bilaterally. There were no differences in white matter volumes between patients with depression and healthy control subjects. The most important limitation of this study was sample size. A larger sample size may have improved detection of changes not reaching significance. Furthermore, our results may not be generalizable across depression severity or to hospitalized patients. The findings are consistent with our hypothesis that depression in the elderly is associated with local gray matter dysfunction.

Integrity signals

Registry

Crossref · 10.1016/j.pscychresns.2007.12.018

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Moderate gray matter loss has been observed in subcortical regions including putamen, caudate nucleus, amygdala, and thalamus in MDD.

    “Moderate GM loss has also been observed in subcortical regions including the putamen and caudate nucleus, as well as the amygdala and thalamus (Egger et al., 2008; Tang et al., 2007).”

    From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Egger et al., 2008

  • Two recent meta-analyses show convergent findings for cingulate and orbitofrontal cortex regions but differ in findings relating to striatal and limbic structures.

    “The heterogeneity between studies is echoed in two recent meta-analyses which show convergent findings for cingulate and OFC regions but differ in their findings relating to striatal and limbic structures (Egger et al., 2008; Tang et al., 2007).”

    From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Egger et al., 2008

Cites

Flagged first, then by citations

1 of the 47 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Egger, K., Schocke, M., Weiss, E., Auffinger, S., Esterhammer, R., Goebel, G., Walch, T., Mechtcheriakov, S., & Marksteiner, J.
Affiliations
  • Innsbruck Medical University (AT)
  • Klinikum Klagenfurt (AT)
Corresponding author
Marksteiner, Josef
ORCID
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2008-12
Volume
164
Issue
3
Pages
237-244
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2007.12.018
OpenAlex
W2047189322
Cited by
113
References
47
Citations by year
2025: 3 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 15 · 2012: 13
FWCI
4.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
geriatric depression, late-onset depression, brain atrophy, gray matter volume, white matter volume, hippocampus, amygdala, medial orbitofrontal cortex, cognitive impairment, executive function, memory impairment, voxel-based morphometry
MeSH terms
Aged, Aged, 80 and over, Amygdala, Atrophy, Brain, Cognition Disorders, Depression, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review