The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Nutritional therapy improves function and complements corticosteroid intervention in mdx mice
Abstract
Corticosteroid therapy for Duchenne muscular dystrophy is effective but associated with long‐term side effects. To determine the potential therapeutic benefit from four nutritional compounds (creatine monohydrate, conjugated linoleic acid, α‐lipoic acid, and β‐hydroxy‐β‐methylbutyrate) alone, in combination, and with corticosteroids (prednisolone), we evaluated the effects on several variables in exercising mdx mice. Outcome measures included grip strength, rotarod performance, serum creatine kinase levels, muscle metabolites, internalized myonuclei, and retroperitoneal fat pad weight. In isolation, each nutritional treatment showed some benefit, with the combination therapy showing the most consistent benefits. Prednisolone and the combination therapy together provided the most consistent evidence of efficacy; increased peak grip strength (P < 0.05), decreased grip strength fatigue (P < 0.05), decreased number of internalized myonuclei (P < 0.01), and smaller retroperitoneal fat pad stores (P < 0.001). This study provided evidence for therapeutic benefit from a four‐compound combination therapy alone, and in conjunction with corticosteroids in the mdx model of DMD. Muscle Nerve, 2005
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“Pre-clinical studies have shown pathological and functional benefits from CrM supplementation in murine models of DMD [196–199], and also in a murine model of fascio-scapulo-humeral dystrophy (FSHD) [200].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [196]
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Metadata
- Authors
- Payne, E. T., Yasuda, N., Bourgeois, J. M., Devries, M. C., Rodriguez, M. C., Yousuf, J., & Tarnopolsky, M. A.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2005-09-07
- Volume
- 33
- Issue
- 1
- Pages
- 66-77
- ISSN
- 0148-639X
- 1097-4598
- Cited by
- 71
- References
- 11
- Language
- en
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