The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Lengthening our perspective: Morphological, cellular, and molecular responses to eccentric exercise
Abstract
The response of skeletal muscle to unaccustomed eccentric exercise has been studied widely, yet it is incompletely understood. This review is intended to provide an up‐to‐date overview of our understanding of how skeletal muscle responds to eccentric actions, with particular emphasis on the underlying molecular and cellular mechanisms of damage and recovery. This review begins by addressing the question of whether eccentric actions result in physical damage to muscle fibers and/or connective tissue. We next review the symptomatic manifestations of eccentric exercise (i.e., indirect damage markers, such as delayed onset muscle soreness), with emphasis on their relatively poorly understood molecular underpinnings. We then highlight factors that potentially modify the muscle damage response following eccentric exercise. Finally, we explore the utility of using eccentric training to improve muscle function in populations of healthy and aging individuals, as well as those living with neuromuscular disorders. Muscle Nerve 49: 155–170, 2014
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regulatory interactions between muscle and the immune system during muscle regeneration
Tidball, J. G., & Villalta, S. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2009 · Cited by 1,105 · cited 4×
“While we will briefly review links between inflammation and DOMS below, other recent reviews of muscle inflammation postinjury provide more comprehensive details of this complex and highly coordinated response.(45,78,79) A theoretical framework summarizing possible mechanisms for delayed muscle soreness following ecce…”
BackgroundInfluentialDefective membrane repair in dysferlin-deficient muscular dystrophy
Bansal, D., Miyake, K., Vogel, S. S., Groh, S., Chen, C.-C., Williamson, R., McNeil, P. L., & Campbell, K. P. (2003) · Nature · doi:10.1038/nature01573 · Cited by 1,022
Muscle function after exercise-induced muscle damage and rapid adaptation
CLARKSON, P. M., NOSAKA, K., & BRAUN, B. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199205000-00004 · Cited by 970
Initial events in exercise-induced muscular injury
BEN KIBLER, C. W., & ARMSTRONG, R. B. (1990) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199008000-00002 · Cited by 457
Crameri, R. M., Aagaard, P., Qvortrup, K., Langberg, H., Olesen, J., & Kjær, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.128827 · Cited by 319 · cited 3×
“Furthermore, recent data suggest that experimental animal models that rely on electrical stimulation to induce eccentric actions may not be physiologically representative of damage induced by voluntary contractions in humans.(22)”
BackgroundInfluentialDifferential adaptations to eccentric versus conventional resistance training in older humans
Reeves, N. D., Maganaris, C. N., Longo, S., & Narici, M. V. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.046599 · Cited by 274
Moore, D. R., Phillips, S. M., Babraj, J. A., Smith, K., & Rennie, M. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2004 · Cited by 268
Age-related muscle dysfunction
Thompson, L. V. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.003 · Cited by 226
Cooke, M. B., Rybalka, E., Williams, A. D., Cribb, P. J., & Hayes, A. (2009) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-6-13 · Cited by 126
Cited by
Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise
Wackerhage, H., Schoenfeld, B. J., Hamilton, D. L., Lehti, M., & Hulmi, J. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00685.2018 · Cited by 357
Damas, F., Libardi, C. A., & Ugrinowitsch, C. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3792-9 · Cited by 254
Clifford, T., Bell, O., West, D. J., Howatson, G., & Stevenson, E. J. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3290-x · Cited by 117
Effect of Branched-Chain Amino Acid Supplementation on Recovery Following Acute Eccentric Exercise
VanDusseldorp, T. A., Escobar, K. A., Johnson, K. E., Stratton, M. T., Moriarty, T., Cole, N., McCormick, J. J., Kerksick, C. M., Vaughan, R. A., Dokladny, K., et al. (2018) · Nutrients · doi:10.3390/nu10101389 · Cited by 78
Doma, K., Singh, U., Boullosa, D., & Connor, J. D. (2021) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2021-0110 · Cited by 34
Metadata
- Authors
- Hyldahl, R. D., & Hubal, M. J.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2013-12-03
- Volume
- 49
- Issue
- 2
- Pages
- 155-170
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W1860145234
- Cited by
- 346
- References
- 9
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Lengthening our perspective: Morphological, cellular, and molecular responses to eccentric exercise. https://app.cochat.ai/papers/10.1002/mus.24077
- The paper
- Hyldahl, R. D., & Hubal, M. J. (2014). Lengthening our perspective: Morphological, cellular, and molecular responses to eccentric exercise. Muscle & Nerve. https://doi.org/10.1002/mus.24077
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
