Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions

Moore, Daniel R.; Phillips, Stuart M.; Babraj, John A.; Smith, Kenneth; Rennie, Michael J.

doi:10.1152/ajpendo.00387.2004

Cited by 268Muscle metabolism and nutritionMuscle Physiology and DisordersCardiovascular and exercise physiology

Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions

Moore, Daniel R., Phillips, Stuart M., Babraj, John A., Smith, Kenneth, Rennie, Michael J.·2005·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00387.2004

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Abstract

We aimed to determine whether there were differences in the extent and time course of skeletal muscle myofibrillar protein synthesis (MPS) and muscle collagen protein synthesis (CPS) in human skeletal muscle in an 8.5-h period after bouts of maximal muscle shortening (SC; average peak torque = 225 +/- 7 N.m, means +/- SE) or lengthening contractions (LC; average peak torque = 299 +/- 18 N.m) with equivalent work performed in each mode. Eight healthy young men (21.9 +/- 0.6 yr, body mass index 24.9 +/- 1.3 kg/m2) performed 6 sets of 10 maximal unilateral LC of the knee extensors on an isokinetic dynamometer. With the contralateral leg, they then performed 6 sets of maximal unilateral SC with work matched to the total work performed during LC (10.9 +/- 0.7 vs. 10.9 +/- 0.8 kJ, P = 0.83). After exercise, the participants consumed small intermittent meals to provide 0.1 g.kg(-1).h(-1) of protein and carbohydrate. Prior exercise elevated MPS above rest in both conditions, but there was a more rapid rise after LC (P < 0.01). The increases (P < 0.001) in CPS above rest were identical for both SC and LC and likely represent a remodeling of the myofibrillar basement membrane. Therefore, a more rapid rise in MPS after maximal LC could translate into greater protein accretion and muscle hypertrophy during chronic resistance training utilizing maximal LC.

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Skeletal muscle protein synthesis signaling, via activation of the mTORC1 pathway, is stimulated in the range of 1-7 days post-damage in response to various eccentric or lengthening contraction protocols in rodents and humans.
“Skeletal muscle protein synthesis signaling, via activation of the mTORC1 pathway, is stimulated in the range of 1–7 days post-damage in response to various eccentric or lengthening contraction protocols in rodents and humans (57–61).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [60]

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Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.
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Muscle Collagen Synthesis in Human Quadriceps in Response to Maximal Shortening and Lengthening Contractions
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Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
Holm, L., van Hall, G., Rose, A. J., Miller, B. F., Doessing, S., Richter, E. A., & Kjaer, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00609.2009 · Cited by 132 · see citing works
Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men
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Self-citation
(2014) Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men. PLoS ONE
(2014)
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
Miller, B. F., Olesen, J. L., Hansen, M., Døssing, S., Crameri, R. M., Welling, R. J., Langberg, H., Flyvbjerg, A., Kjaer, M., Babraj, J. A., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093690 · Cited by 610 · see citing works
Self-citation

Authors: Moore, D. R., Phillips, S. M., Babraj, J. A., Smith, K., & Rennie, M. J.
Affiliations: McMaster University (CA)
University of Dundee (GB)
University of Nottingham (GB)
ORCID: Moore, Daniel R.
Phillips, Stuart M.
Babraj, John A.
Smith, Kenneth
Rennie, Michael J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2005-06
Volume: 288
Issue: 6
Pages: E1153-E1159
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00387.2004
OpenAlex: W2125844006
Cited by: 268
References: 25
Citations by year: 2026: 10 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 5 · 2021: 16 · 2020: 13 · 2019: 15 · 2018: 7 · 2017: 21 · 2016: 15 · 2015: 15 · 2014: 13 · 2013: 14 · 2012: 17
FWCI: 3.83
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: myofibrillar protein synthesis, skeletal muscle, eccentric contraction, shortening contractions, muscle hypertrophy, muscle remodeling, resistance training, knee extensors
MeSH terms: Adult, Amino Acids, Blood Chemical Analysis, Blood Glucose, Collagen, Histocytochemistry, Humans, Insulin, Leg, Male, Muscle Contraction, Muscle Proteins, Myofibrils, Oxygen Consumption, Exercise, Muscle, Skeletal

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Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions

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