Associations of quadriceps torque properties with muscle size, attenuation, and intramuscular adipose tissue in older adults
Open accessAbstract
Background: Atrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intramuscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques. Methods: Data from 4,842 participants (2,041 men, 2,801 women) from the Age Gene/Environment Susceptibility Reykjavik Study (mean age 76 ± 0.1 years) with complete thigh computed tomography and isometric knee testing. Regression models were adjusted for health, behavior, and comorbidities. Muscle attenuation was further adjusted for muscle area and IMAT; muscle area adjusted for IMAT and attenuation; and IMAT adjusted for muscle area and attenuation. Standardized betas (β) indicate association effect sizes. Results: In the fully-adjusted models, attenuation (men β = 0.06, 95% CI: 0.01, 0.11; women β = 0.07, 95% CI: 0.03, 0.11) and muscle area (men β = 0.13, 95% CI: 0.07, 0.19; women β = 0.10, 95% CI: 0.06, 0.15) were associated with knee RTD. Attenuation (men β = 0.12, 95% CI: 0.08, 0.16; women β = 0.12, 95% CI: 0.09, 0.16) and muscle area (men β = 0.38, 95% CI: 0.33, 0.43; women β = 0.33, 95% CI: 0.29, 0.37) were associated with peak torque. Conclusions: These data suggest that muscle attenuation and area are independently associated with RTD and peak torque; and that area and attenuation demonstrate similar contributions to RTD.
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In both the Health ABC and AGES studies, even when controlling for body composition, muscle attenuation was associated with increased risk of fracture.
“In both studies, even when controlling for body composition, the muscle attenuation was associated with increased risk of fracture (Lang et al., 2010; Johannesdottir et al., 2012; Frank-Wilson et al., 2018).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Frank-Wilson et al., 2018
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- Authors
- Frank-Wilson, A. W., Chalhoub, D., Figueiredo, P., Jónsson, P. V., Siggeirsdóttir, K., Sigurdsson, S., Eiriksdottir, G., Guðnason, V., Launer, L., Harris, T. B., & Study, T. A.-R.
- Affiliations
- National Institutes of Health (US)
- University of Iceland (IS)
- Icelandic Heart Association (IS)
- Icelandic Heart Association Research Institute, Reykjavik, Iceland
- Faculty of Medicine, University of Iceland, Reykjavik
- Corresponding author
- Frank-Wilson, Andrew W
- ORCID
- Venue
- The Journals of Gerontology Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-12
- Volume
- 73
- Issue
- 7
- Pages
- 931-938
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC6001898
- OpenAlex
- W2794919000
- Cited by
- 37
- References
- 33
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 2 · 2018: 3
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- The Journals of Gerontology Series A (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- National Institutes of Health (N01-AG-12100)
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- quadriceps, muscle attenuation, intramuscular fat, muscle size, knee extension torque, muscle atrophy, sarcopenia, aging, older adults, muscle function
- MeSH terms
- Adipose Tissue, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Female, Humans, Iceland, Isometric Contraction, Male, Tomography, X-Ray Computed, Torque, Quadriceps Muscle, Muscle Strength
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