Intensive Behavioral Therapy for Obesity Combined with Liraglutide 3.0 mg: A Randomized Controlled Trial

Wadden, Thomas A.; Walsh, Olivia A.; Berkowitz, Robert I.; Chao, Ariana M.; Alamuddin, Naji; Gruber, Kathryn; Leonard, Sharon; Mugler, Kimberly; Bakizada, Zayna; Tronieri, Jena Shaw

doi:10.1002/oby.22359

Cited by 116Diabetes, Cardiovascular Risks, and LipoproteinsPharmacology and Obesity TreatmentBariatric Surgery and Outcomes

Intensive Behavioral Therapy for Obesity Combined with Liraglutide 3.0 mg: A Randomized Controlled Trial

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Wadden, Thomas A., Walsh, Olivia A., Berkowitz, Robert I., Chao, Ariana M., Alamuddin, Naji, Gruber, Kathryn, Leonard, Sharon, Mugler, Kimberly +2 more·2019·Obesity

DOI 10.1002/oby.22359PMC PMC6800068

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Abstract

Objective: The Centers for Medicare and Medicaid Services (CMS) covers intensive behavioral therapy (IBT) for obesity. The efficacy, however, of the specific approach has never been evaluated in a randomized trial, as described here. The 1‐year trial also assessed whether the addition to IBT of liraglutide 3.0 mg would significantly increase weight loss and whether the provision of meal replacements would add further benefit. Methods: A total of 150 adults with obesity were randomly assigned to: IBT (IBT‐alone), providing 21 counseling visits; IBT combined with liraglutide (IBT‐liraglutide); or IBT‐liraglutide combined for 12 weeks with a 1,000‐ to 1,200‐kcal/d meal‐replacement diet (Multicomponent). All participants received weekly IBT visits in month 1, every‐other‐week visits in months 2 to 6, and monthly sessions thereafter. Results: Ninety‐one percent of participants completed 1 year, at which time mean (± SEM) losses for IBT‐alone, IBT‐liraglutide, and Muticomponent participants were 6.1 ± 1.3%, 11.5 ± 1.3%, and 11.8 ± 1.3% of baseline weight, respectively. Fully 44.0%, 70.0%, and 74.0% of these participants lost ≥ 5% of weight, respectively. The liraglutide‐treated groups were superior to IBT‐alone on both outcomes. Weight loss in all three groups was associated with clinically meaningful improvements in cardiometabolic risk factors. Conclusions: The findings demonstrate the efficacy of IBT for obesity and the potential benefit of adding pharmacotherapy to this approach.

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Once-daily liraglutide, 3.0 mg, added approximately 3 to 5 percentage points of additional weight loss to intensive behavioral therapy compared with behavioral therapy alone.
“Once-daily liraglutide, 3.0 mg, a glucagon-like peptide 1 receptor agonist approved for weight management, added approximately 3 to 5 percentage points of additional weight loss to intensive behavioral therapy compared with behavioral therapy alone.9,10”
From Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial (2021) · cites this paper as [9]

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Authors: Wadden, T. A., Walsh, O. A., Berkowitz, R. I., Chao, A. M., Alamuddin, N., Gruber, K., Leonard, S., Mugler, K., Bakizada, Z., & Tronieri, J. S.
Affiliations: University of Pennsylvania (US)
Children's Hospital of Philadelphia (US)
Corresponding author: Wadden, Thomas A.
ORCID: Wadden, Thomas A.
Walsh, Olivia A.
Berkowitz, Robert I.
Chao, Ariana M.
Leonard, Sharon
Tronieri, Jena Shaw
Venue: Obesity
Publisher: Wiley
Published: 2018-11-13
Volume: 27
Issue: 1
Pages: 75-86
ISSN: 1930-7381 (ISSN-L)
1930-739X
DOI: 10.1002/oby.22359
PMC: PMC6800068
OpenAlex: W2900765417
Cited by: 116
References: 40
Citations by year: 2026: 12 · 2025: 21 · 2024: 17 · 2023: 14 · 2022: 13 · 2021: 13 · 2020: 12 · 2019: 14
FWCI: 7.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Obesity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Novo Nordisk UK Research Foundation (This trial was supported by an Investigator Initia)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords: liraglutide, weight loss, meal replacement, pharmacotherapy, cardiometabolic risk factors, obesity treatment efficacy
MeSH terms: Liraglutide, Aged, Behavior Therapy, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Obesity, Treatment Outcome

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Intensive Behavioral Therapy for Obesity Combined with Liraglutide 3.0 mg: A Randomized Controlled Trial

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