Integrins in regulation of tissue development and function

Untitled work

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Integrin signaling

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Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

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β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

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Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

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Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis

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Embryonic mesodermal defects in α5 integrin-deficient mice

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Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

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The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

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Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

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Structure and Function of Hemidesmosomes: More Than Simple Adhesion Complexes

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Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

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Reelin Binds α3β1 Integrin and Inhibits Neuronal Migration

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Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

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Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

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Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

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Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

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The Evolution of Cell Adhesion

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Fibronectin, integrins, and growth control

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Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

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Absence of integrin α7 causes a novel form of muscular dystrophy

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Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

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Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation

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Integrins in Development

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Integrin α8β1 Is Critically Important for Epithelial–Mesenchymal Interactions during Kidney Morphogenesis

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Integrin activation takes shape

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α5β1 Integrin Controls Cyclin D1 Expression by Sustaining Mitogen-activated Protein Kinase Activity in Growth Factor-treated Cells

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α4 Integrins Regulate the Proliferation/Differentiation Balance of Multilineage Hematopoietic Progenitors In Vivo

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Integrins: Redundant or Important Players in Skeletal Muscle?

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Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras

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A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

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Reelin Is a Serine Protease of the Extracellular Matrix

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Requirement for integrins during Drosophila wing development

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Absence of PS Integrins or Laminin A Affects Extracellular Adhesion, but Not Intracellular Assembly, of Hemiadherens and Neuromuscular Junctions inDrosophilaEmbryos

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Dystrophic Muscle in Mice Chimeric for Expression of α5 Integrin

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A Novel Function for the Tumor Suppressor p16INK4a

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Genetic analysis of integrin function in man: LAD-1 and other syndromes

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Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic developmentPreprint

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Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin.

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A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3

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