Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients: Extraction Optimization, Chemical Characterization, and Biological Activity
Open accessAbstract
A green ultrasound-assisted extraction (UAE) method using glycerol/water mixtures for extraction of licorice (Glycyrrhiza glabra) bioactive constituents was developed in this study. The response surface method, according to the Box-Behnken design, was employed to optimize the extraction parameters: glycerol concentration (X1), temperature (X2), and the amount of herbal drug used in the production (X3). The responses were content of total phenols (TP), TP extraction efficiency (TPy) and the content of licorice characteristic constituents, glabridin (Gla) and isoliquiritigenin (Iso). Response surface analysis predicted the optimal extraction conditions for maximized amounts of TP, Tpy, Gla, and Iso. The extracts were prepared using the calculated conditions. The analysis of the selected constituents confirmed the validity of the model. Furthermore, biological activity of the extracts was tested. The results demonstrate that UAE using glycerol is a fast and efficient method for preparation of extracts with excellent radical scavenging, Fe2+ chelating and antioxidant activity. Furthermore, the observed notable tyrosinase and elastase inhibitory activity of the extracts, as well as their anti-inflammatory activity, indicate the anti-aging properties of the investigated extracts. The fact that the extracts were prepared using the safe, cosmetically active solvent, glycerol, makes them suitable for direct use in specialized cosmeceutical formulations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Functional cosmeceutical ingredients with anti-oxidant activity offer protection against oxidative damage of skin macromolecules associated with effects of free radicals and UV radiation on the skin.
“They also offer protection against oxidative damage of skin macromolecules associated with the effects of free radicals and UV radiation on the skin [58,75].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [58]
G. glabra extract obtained by green ultrasound-assisted extraction with glycerol/water mixtures has good anti-oxidant activity, tyrosinase and elastase inhibitory activity, and anti-inflammatory activity, leading to anti-aging properties.
“Moreover, Ciganovic et al. highlighted for G. glabra extract, obtained by a green ultrasoundassisted extraction method using glycerol/water mixtures, a good anti-oxidant activity, tyrosinase, and elastase inhibitory activity as well as anti-inflammatory activity, leading to excellent anti-aging properties [58].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999) · Methods in Enzymology · doi:10.1016/s0076-6879(99)99017-1 · Cited by 19,125 · see citing works
Green Extraction of Natural Products: Concept and Principles
Chemat, F., Vian, M. A., & Cravotto, G. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078615 · Cited by 1,904 · see citing works
An Updated Review of Tyrosinase Inhibitors
Chang, T. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10062440 · Cited by 1,555 · see citing works
Antioxidant activity of propolis of various geographic origins
Kumazawa, S., Hamasaka, T., & Nakayama, T. (2003) · Food Chemistry · doi:10.1016/s0308-8146(03)00216-4 · Cited by 952 · see citing works
Liquorice ( <scp> <i>Glycyrrhiza glabra</i> </scp> ): A phytochemical and pharmacological review
Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6178 · Cited by 804 · see citing works
Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein
Chandra, S., Chatterjee, P., Dey, P., & Bhattacharya, S. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60154-3 · Cited by 512 · see citing works
Phytochemistry and biological properties of glabridin
Simmler, C., Pauli, G. F., & Chen, S.-N. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.07.003 · Cited by 281 · see citing works
Method Validation in Pharmaceutical Analysis
(2005) · Wiley eBooks · doi:10.1002/3527604685 · Cited by 272 · see citing works
Glycerol as a green solvent for high product yields and selectivities
Wolfson, A., Dlugy, C., & Shotland, Y. (2006) · Environmental Chemistry Letters · doi:10.1007/s10311-006-0080-z · Cited by 247 · see citing works
Kantar, S. E., Rajha, H. N., Boussetta, N., Vorobiev, E., Maroun, R. G., & Louka, N. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.05.111 · Cited by 226 · see citing works
Resveratrol as an active ingredient for cosmetic and dermatological applications: a review
Ratz-Łyko, A., & Arct, J. (2019) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2018.1469767 · Cited by 216 · see citing works
Delivery systems for cosmetics-from manufacturing to the skin of natural antioxidants
Costa, R., & Santos, L. (2017) · Powder Technology · doi:10.1016/j.powtec.2017.07.086 · Cited by 215 · see citing works
Yahya, N. A., Attan, N., & Wahab, R. A. (2018) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2018.09.002 · Cited by 159 · see citing works
Coffee Silverskin: A Review on Potential Cosmetic Applications
Bessada, S., C. Alves, R., & P. P. Oliveira, M. (2018) · Cosmetics · doi:10.3390/cosmetics5010005 · Cited by 126 · see citing works
Castangia, I., Caddeo, C., Manca, M. L., Casu, L., Catalán-Latorre, A., Dı́ez-Sales, O., Ruiz‐Saurí, A., Bacchetta, G., Fadda, A. M., & Manconi, M. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.08.037 · Cited by 122 · see citing works
Kondo, K., Shiba, M., Nakamura, R., Morota, T., & Shoyama, Y. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1271 · Cited by 120 · see citing works
Bose, B., Choudhury, H., Tandon, P., & Kumaria, S. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.07.010 · Cited by 117 · see citing works
Apostolakis, A., Grigorakis, S., & Makris, D. P. (2014) · Separation and Purification Technology · doi:10.1016/j.seppur.2014.03.010 · Cited by 116 · see citing works
Shehata, E., Grigorakis, S., Loupassaki, S., & Makris, D. P. (2015) · Separation and Purification Technology · doi:10.1016/j.seppur.2015.06.017 · Cited by 91 · see citing works
Imokawa, G. (2007) · Archives of Dermatological Research · doi:10.1007/s00403-007-0798-x · Cited by 89 · see citing works
Oxidants and Antioxidants in Cutaneous Biology
Thiele, J. J., & Elsner, P. U. (2000) · Current problems in dermatology · doi:10.1159/isbn.978-3-318-00629-2 · Cited by 89 · see citing works
Jug, M., Končić, M. Z., & Kosalec, I. (2014) · LWT · doi:10.1016/j.lwt.2014.02.006 · Cited by 81 · see citing works
Antiradical, Chelating and Antioxidant Activities of Hydroxamic Acids and Hydroxyureas
Končić, M. Z., Barbarić, M., Perković, I., & Zorc, B. (2011) · Molecules · doi:10.3390/molecules16086232 · Cited by 79 · see citing works
Handbook of Cosmetic Science and Technology
(2001) · CRC Press eBooks · doi:10.1201/9780824741396 · Cited by 73 · see citing works
Liao, W. C., Lin, Y.-H., Chang, T., & Huang, W.-Y. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.12.051 · Cited by 72 · see citing works
Iron (II) Ions Induced Oxidation of Ascorbic Acid and Glucose
Mlakar, A., Batna, A., Dudda, A., & Spiteller, G. (1996) · Free Radical Research · doi:10.3109/10715769609149074 · Cited by 50 · see citing works
The Importance of Some Plant Extracts as Skin Anti-aging Resources: A Review
Yasin, Z. A. M., Ibrahim, F., Rashid, N. N., Razif, M. F. M., & Yusof, R. (2017) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201019666171219105920 · Cited by 49 · see citing works
Zhou, Y., Xu, X., Gan, R., Zheng, J., Li, Y., Zhang, J., Xu, D.-P., & Li, H. (2019) · Antioxidants · doi:10.3390/antiox8070200 · Cited by 48 · see citing works
Rouhani, M. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.02.029 · Cited by 47 · see citing works
Limwachiranon, J., Jiang, L., Huang, H., Sun, J., & Luo, Z. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.09.022 · Cited by 47 · see citing works
Kotian, S., Kumar, B., Sreedhara, P., Jayakrishna, N., Souza, A. D., Karthik, G., & Padma, D. (1970) · Ethiopian Journal of Health Sciences · doi:10.4314/ejhs.v28i6.11 · Cited by 41 · see citing works
Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice
Yu, H., Li, H., Li, Y., Li, M., & Chen, G. (2017) · Archives of Dermatological Research · doi:10.1007/s00403-017-1787-3 · Cited by 35 · see citing works
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity
Rajić, Z., Končić, M. Z., Miloloža, K., Perković, I., Butula, I., Bučar, F., & Zorc, B. (2010) · Acta Pharmaceutica · doi:10.2478/v10007-010-0024-9 · Cited by 33 · see citing works
Polyphenolic Profile and Antioxidant Capacity of Extracts from Gordonia axillaris Fruits
Li, Y., Cao, S., Lin, S.-J., Zhang, J.-R., Gan, R., & Li, H. (2019) · Antioxidants · doi:10.3390/antiox8060150 · Cited by 29 · see citing works
Stability of Collagen During Denaturation
Komsa‐Penkova, R., Goshev, I., Gorinstein, S., & NEDKOV, P. (1999) · Journal of Protein Chemistry · doi:10.1023/a:1020632424142 · Cited by 28 · see citing works
Mostafa, D. M., Ammar, N. M., El-Alim, S. H. A., & El‐Anssary, A. A. (2013) · Drug Delivery · doi:10.3109/10717544.2013.834419 · Cited by 23 · see citing works
Tada, A., Ishizuki, K., Sugimoto, N., Yoshimatsu, K., Kawahara, N., Suematsu, T., Arifuku, K., Fukai, T., Tamura, Y., OHTSUKI, T., et al. (2015) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.56.217 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [9]Glória M.B.A. SWEETENERS|Others Encyclopedia of Food Sciences and Nutrition 2nd ed. Caballero B. Academic Press Oxford, MA, USA 2003 5695 5702
Cited by
Sorted by citations
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2
Chaiprasongsuk, A., & Panich, U. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823881 · Cited by 128 · see citing works
Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
Waseem, M. A., Majeed, Y., Nadeem, T., Naqvi, L. H., Khalid, M. A., Sajjad, M. M., Sultan, M. T., Khan, M. U., Khayrullin, M., Shariati, M. A., et al. (2023) · Food Frontiers · doi:10.1002/fft2.296 · Cited by 83 · see citing works
Makris, D. P., & Lalas, S. I. (2020) · Molecules · doi:10.3390/molecules25245842 · Cited by 80 · see citing works
Bisht, D., Rashid, M., Arya, R. K. K., Kumar, D., Chaudhary, S. K., Rana, V. S., & Sethiya, N. K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100206 · Cited by 83 · see citing works
Jakimiuk, K., Sarı, S., Milewski, R. J., Supuran, C. T., Şöhretoğlu, D., & Tomczyk, M. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.2014832 · Cited by 64 · see citing works
Self-citationAntioxidant and Anti-Inflammatory Properties of Plants Extract
Allegra, M. (2019) · Antioxidants · doi:10.3390/antiox8110549 · Cited by 58 · see citing works
Plant Fortification of the Diet for Anti-Ageing Effects: A Review
Dhanjal, D. S., Bhardwaj, S., Sharma, R., Bhardwaj, K., Kumar, D., Chopra, C., Nepovimová, E., Singh, R., & Kuča, K. (2020) · Nutrients · doi:10.3390/nu12103008 · Cited by 55 · see citing works
Gamage, D. G. N. D., Dharmadasa, R. M., Abeysinghe, D. C., Wijesekara, R. G. S., Prathapasinghe, G. A., & Someya, T. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9940548 · Cited by 53 · see citing works
Choi, H. Y., Lee, Y. J., Kim, C. M., & Lee, Y. (2024) · Cosmetics · doi:10.3390/cosmetics11050157 · Cited by 49 · see citing works
Momchev, P., Ciganović, P., Jug, M., Marguí, E., Jablan, J., & Končić, M. Z. (2020) · Molecules · doi:10.3390/molecules25215142 · Cited by 41 · see citing works
Self-citationSilybum marianum glycerol extraction for the preparation of high-value anti-ageing extracts
Jabłonowska, M., Ciganović, P., Jablan, J., Marguí, E., Tomczyk, M., & Končić, M. Z. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.113613 · Cited by 37 · see citing works
Self-citationSrisuksomwong, P., Kaenhin, L., & Mungmai, L. (2023) · Cosmetics · doi:10.3390/cosmetics10010017 · Cited by 40 · see citing works
Advances in obtaining ready to use extracts with natural solvents
Queffelec, J., Beraud, W., Torres, M. D., & Domı́nguez, H. (2024) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2024.101478 · Cited by 38 · see citing works
Poustforoosh, A., Faramarz, S., Negahdaripour, M., Tüzün, B., & Hashemipour, H. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2196347 · Cited by 33 · see citing works
Anti-Aging Effect of Traditional Plant-Based Food: An Overview
Das, G., Kameswaran, S., Ramesh, B., Manjunatha, B., Nath, R., Talukdar, A. D., Shin, H., & Patra, J. K. (2024) · Foods · doi:10.3390/foods13233785 · Cited by 33 · see citing works
Tabassum, S., Ahmad, S., Khan, K.-U.-R., Ali, B., Usman, F., Jabeen, Q., Sajid-ur-Rehman, M., Ahmed, M., Zubair, H. M., Alkazmi, L. M., et al. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104784 · Cited by 29 · see citing works
Advances of Imidazolium Ionic Liquids for the Extraction of Phytochemicals from Plants
Gong, J., Liang, C., Majeed, Z., Tian, M., Zhao, C., Luo, M., & Li, C. (2023) · Separations · doi:10.3390/separations10030151 · Cited by 28 · see citing works
Basit, A., Ahmad, S., Khan, K.-U.-R., Sherif, A. E., Aati, H. Y., Ovatlarnporn, C., Khan, M. A., Rao, H., Ahmad, S., Shahzad, M. N., et al. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.104135 · Cited by 25 · see citing works
Fatoki, T. H., Ajiboye, B. O., & Aremu, A. O. (2023) · Cosmetics · doi:10.3390/cosmetics10030069 · Cited by 27 · see citing works
Jakupović, L., Bačić, I., Jablan, J., Marguí, E., Marijan, M., Inić, S., Nodilo, L. N., Hafner, A., & Končić, M. Z. (2023) · Antioxidants · doi:10.3390/antiox12040855 · Cited by 21 · see citing works
Juszczak, A. M., Marijan, M., Jakupović, L., Tomczykowa, M., Tomczyk, M., & Končić, M. Z. (2022) · Metabolites · doi:10.3390/metabo13010032 · Cited by 20 · see citing works
Self-citationBioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors
Wong, F., & Chai, T. (2023) · Biology · doi:10.3390/biology12070917 · Cited by 17 · see citing works
Plant Tissue Culture: Industrial Relevance and Future Directions
Zuzarte, M., Salgueiro, L., & Canhoto, J. (2024) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2024_254 · Cited by 18 · see citing works
Marijan, M., Mitar, A., Jakupović, L., Kardum, J. P., & Končić, M. Z. (2022) · Molecules · doi:10.3390/molecules27020529 · Cited by 16 · see citing works
Wound Healing Properties of Jasione montana Extracts and Their Main Secondary Metabolites
Juszczak, A. M., Jakimiuk, K., Czarnomysy, R., Strawa, J. W., Končić, M. Z., Bielawski, K., & Tomczyk, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.894233 · Cited by 15 · see citing works
Self-citationGhica, A., Drumea, V., Moroşan, A., Mihăiescu, D. E., Costea, L., Luță, E. A., Mihai, D. P., Balaci, T. D., Fița, A. C., Olaru, O. T., et al. (2023) · Plants · doi:10.3390/plants12132510 · Cited by 15 · see citing works
Chandran, A., Syam, R. J., Jerone, J. J., & Kaimal, S. (2022) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v13i3.2867 · Cited by 14 · see citing works
Wang, J.-Y., Xie, X.-Y., Deng, Y., Yang, H., Du, X., Liu, P., & Du, Y. (2022) · Acta Cirúrgica Brasileira · doi:10.1590/acb371002 · Cited by 12 · see citing works
Wen, Z., Yu, J., Jeong, H., Kim, D.-U., Yang, J. Y., Hyun, K., Choi, S., Park, S., & Jung, H. (2023) · Lab on a Chip · doi:10.1039/d3lc00585b · Cited by 11 · see citing works
The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability
Li, C., Wang, Y. T., Zhang, W., Yang, X., Wang, Y., Hou, G., Wang, D., Han, B., & Zhang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1506588 · Cited by 11 · see citing works
Soleimani, M., Rezaie, S., Nabizadeh, R., Khaniki, G. J., Alimohammadi, M., Alikord, M., Noorbakhsh, F., Molaee-Aghaee, E., & Ghanbari, R. (2021) · Journal of Environmental Health Science and Engineering · doi:10.1007/s40201-021-00677-y · Cited by 11 · see citing works
Grigorakis, S., Halahlah, A., & Makris, D. P. (2020) · Sustainability · doi:10.3390/su12124840 · Cited by 11 · see citing works
Liang, Y.-F., Wen, Q., Yang, Z.-F., Li, C., & Li, F. (2023) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2023.101385 · Cited by 10 · see citing works
The role of the mineralocorticoid receptor in skin
Mello, N. F. D., & Bollag, W. B. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112628 · Cited by 7 · see citing works
Özkan, A., Zannou, O., Pashazadeh, H., & Koca, İ. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-03730-4 · Cited by 8 · see citing works
Jakupović, L., Kalvarešin, M., Bukovina, K., Poljak, V., Vujić, L., & Končić, M. Z. (2021) · Molecules · doi:10.3390/molecules26061610 · Cited by 8 · see citing works
Shah, P., Banerjee, S., Singh, A., Kulhari, H., & Saharan, V. A. (2025) · Wiley eBooks · doi:10.1002/9781119769484.ch1 · Cited by 8 · see citing works
Nutraceutical Interventions for Mitigating Skin Ageing: Analysis of Mechanisms and Efficacy
Ibrahim, M., Singh, H., Fahim, M., Khan, S., Khan, J., Arun, J. K., Mishra, A. K., Virmani, T., Sharma, A. K., Kumar, G., et al. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128336661250218080928 · Cited by 6 · see citing works
Wang, L., Li, B., Zhao, X., Ren, S., & Wang, Y. (2021) · BioResources · doi:10.15376/biores.16.2.2346-2368 · Cited by 6 · see citing works
Jakimiuk, K., Strawa, J. W., Granica, S., Locatelli, M., Tartaglia, A., & Tomczyk, M. (2022) · Molecules · doi:10.3390/molecules27062015 · Cited by 6 · see citing works
Self-citationMarijan, M., Jakupović, L., & Končić, M. Z. (2023) · Processes · doi:10.3390/pr11041117 · Cited by 5 · see citing works
LC-ESI-MS profiling of Potentilla norvegica and evaluation of its biological activities
Augustynowicz, D., Jakimiuk, K., Uysal, Ş., Strawa, J. W., Juszczak, A. M., Zengin, G., & Tomczyk, M. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.06.042 · Cited by 5 · see citing works
Self-citationWang, W., Yang, Y., & Tang, K. (2022) · Chemical Engineering Science · doi:10.1016/j.ces.2022.117587 · Cited by 5 · see citing works
Li, Z., Luo, M., Ni, L., Zhou, Q., Jiang, C., Zhu, H., Wang, Z., Liu, Q., & Shu, P. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107309 · Cited by 4 · see citing works
Ghani, A. A., Rashid, N. Y. A., Jamaluddin, A. B., Razak, D. L. A., & Manan, M. A. (2021) · Food Research · doi:10.26656/fr.2017.5(s1).025 · Cited by 4 · see citing works
Lu, Z., Hai, C., Yan, S.-M., Xu, L., Lu, D., Sou, Y., Chen, H., Yang, X., Fu, H., & Yang, J. T. (2022) · Journal of Analytical Methods in Chemistry · doi:10.1155/2022/8906305 · Cited by 4 · see citing works
Chatzikonstantinou, A. V., Bellou, M. G., Spyrou, S., Papanikolaou, A., Simos, Y. V., Peschos, D., & Stamatis, H. (2024) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2024.02.011 · Cited by 4 · see citing works
Strawa, J. W., Jakimiuk, K., Kita, Z., & Tomczyk, M. (2022) · Molecules · doi:10.3390/molecules27228034 · Cited by 4 · see citing works
Self-citationZubair, M., Tousif, M. I., Riaz, N., Saleem, M., Nazir, M., Tauseef, S., Hassan, A., Shah, S. A. A., Zengin, G., Hashem, A., et al. (2024) · International Journal of Food Properties · doi:10.1080/10942912.2024.2409122 · Cited by 3 · see citing works
Natural Products for Cosmeceuticals
Shah, K. C., Verma, K., Trivedi, J. D., Mehta, S. H., Kumar, S., Dhameliya, T. M., & Kathuria, D. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837672288-00001 · Cited by 3 · see citing works
Equilibrium on reactive extraction of glabridin in a quaternary solvent system containing SBE-β-CD
Wang, W., Yang, Y., & Tang, K. (2022) · Process Safety and Environmental Protection · doi:10.1016/j.cherd.2022.05.040 · Cited by 3 · see citing works
Ocular Effects of Glycyrrhizin at Acidic and Neutral pH
Somayajulu, M., McClellan, S. A., Bessert, D. A., Pitchaikannu, A., & Hazlett, L. D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.782063 · Cited by 2 · see citing works
Preventive Role of Nutraceutical Agents Against Aging
Jayasree, R., Thangam, C., Kulanthaivel, L., & Subbaraj, G. K. (2023) · Springer eBooks · doi:10.1007/978-981-99-0534-8_18 · Cited by 2 · see citing works
Medicinal Plants, Antioxidant Potential, and Applications to Aging
Pramanik, A., Maheshwari, S., & Acharya, N. S. (2023) · Springer eBooks · doi:10.1007/978-981-99-7703-1_20 · Cited by 2 · see citing works
Basit, A., Ahmad, S., Ovatlarnporn, C., Arshad, M. A., Saleem, M. F., Khurshid, U., Saleem, H., Khan, K.-U.-R., Khan, S., Alkahtani, H. M., et al. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401432 · Cited by 2 · see citing works
Kürkçü, Ş., Toprakçı, İ., & Şahin, S. (2025) · Chemistry Africa · doi:10.1007/s42250-025-01316-x · Cited by 2 · see citing works
Sallustio, V., Marto, J. M., Escribano‐Ferrer, E., Gonçalves, L., Rossi, M., Cappadone, C., Mandrone, M., Chiocchio, I., Rossello, S., Ribeiro, H. M., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145241 · Cited by 2 · see citing works
Janaki, C., Sachdev, M., & Ritambhara, K. R. (2021) · International Journal of Research in Dermatology · doi:10.18203/issn.2455-4529.intjresdermatol20214203 · Cited by 2 · see citing works
Intensification of the extraction process in the production of licorice root extract
Sokolova, E. V., Maksimenko, Y. A., & Konnova, O. I. (2025) · Proceedings of the Voronezh State University of Engineering Technologies · doi:10.20914/2310-1202-2024-4-185-190 · Cited by 1 · see citing works
Antiaging drugs, candidates, and food supplements: the journey so far
Yodhaanjali, J. R., Surya, R., Sumukha, K. C., Harini, G., Deshpande, G., Chandan, S. A., & Achar, R. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00016-1 · Cited by 1 · see citing works
In Silico Anti-Inflammation Prediction of Glycyrrhiza Extracts Against Covid-19
Nazari, M. (2021) · Journal of Molecular Docking · doi:10.33084/jmd.v1i2.3154
Effect of different solvents on phytochemical and antimicrobial potential of licorice extract
Ahmed, S., Ahmad, A., Izhar, K., Safdar, M. N., Raja, M. U., & Aslam, I. (2022) · World Journal of Biology and Biotechnology · doi:10.33865/wjb.007.01.0474
Research Progress of Functional Nano Drug Carrier Puerarin in The Treatment of Skin Diseases
Yang, M., Ding, C., Liu, X., & Fang, J. (2023) · BIO Web of Conferences · doi:10.1051/bioconf/20236001017
Eslahi, E., & Hashemi, N. (2023) · Current Cosmetic Science · doi:10.2174/2666779702666230731161153
Pharmacology of Glycyrrhiza glabra (Mulhatti): The grandfather of herbs
Srivastav, A. K., & Singh, V. K. (2022) · Journal Of Biotechnology And Crop Science · doi:10.5958/2582-5089.2022.00005.6
Rajagopal, G., Amruthavalli, G. V., & Aruna, V. (2023) · International Journal of Science and Research (IJSR) · doi:10.21275/sr23821183220
Nurcahyo, H., Febriyanti, R., Riyanta, A. B., Sutanto, H., & Herdwiani, W. (2024) · AIP conference proceedings · doi:10.1063/5.0199299
Formulation and Evaluation of Polyherbal Face Scrub Gel for Skin Exfoliation
Metri, S., Mathew, C., Geethasree, M. S., Bhavana, B., Shirisha, E., & Gopi, P. (2025) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v15i2.7013
Bayazitov, K. R., Iakovchenko, N. V., & Antsyperova, M. А. (2026) · Proceedings of the Voronezh State University of Engineering Technologies · doi:10.20914/2310-1202-2026-1-169-175
Tolaini, V., Crinò, P., Giammarco, F. D., Amarelli, M., & Bacchetta, L. (2026) · Applied Sciences · doi:10.3390/app16199649
QORAQALPOG‘ISTONDAGI SHIRINMIYA CHIQINDILARINING FIZIK-KIMYOVIY XUSUSIYATLARI
Uzakbaeva, M. M., K, K. D., Allaniyazov, D. O., Kengesbaeva., D. L., & Aytmuratova, N. K. (2026) · Eurasian Journal of Medical and Natural Sciences · doi:10.70413/ejmns-v06-i09-s58985
Ni, L., Luo, M., Liu, J., Zeng, M., Zeng, L., Jenis, J., Ji, H., Xia, H., Luo, S., Yan, Y., et al. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127489
- Authors
- Ciganović, P., Jakimiuk, K., Tomczyk, M., & Zovko Končić, M.
- Affiliations
- University of Zagreb (HR)
- Medical University of Białystok (PL)
- Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2019-10-01
- Volume
- 8
- Issue
- 10
- Pages
- 445
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC6826613
- OpenAlex
- W2978538299
- Cited by
- 74
- References
- 37
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 18 · 2022: 18 · 2021: 10 · 2020: 4 · 2019: 1
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Croatian Science Foundation (IP-2018-01-6504)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Keywords
- licorice, ultrasound-assisted extraction, cosmeceuticals, glabridin, isoliquiritigenin, total phenolic content, antioxidant activity, free radical scavenging, Fe2+ chelation, tyrosinase inhibition, elastase inhibition, anti-inflammatory activity, anti-aging, green extraction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review