Cited by 831Pharmacological Effects of Natural CompoundsNatural product bioactivities and synthesisMedicinal Plant Research

The DOI matches its Crossref record; 155 of the 157 references it cites were found in a registry or an index.

Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review

Open access

Pastorino, Giulia, Cornara, Laura, Soares, Sónia, Rodrigues, Francisca, Oliveira, M. Beatriz P.P.·2018·Phytotherapy Research

DOI 10.1002/ptr.6178PMC PMC7167772

Open this paper in CoChat — free account Open PDF

Abstract

In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β‐glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti‐inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra . Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well‐being.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/ptr.6178

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Use of NeuroEyeCoach™ to Improve Eye Movement Efficacy in Patients with Homonymous Visual Field Loss
Sahraie, A., Smania, N., & Zihl, J. (2016) · BioMed Research International · doi:10.1155/2016/5186461 · Cited by 1,777
Efficacy of a New Tonic Containing Urea, Lactate, Polidocanol, and Glycyrrhiza inflata Root Extract in the Treatment of a Dry, Itchy, and Subclinically Inflamed Scalp
Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A. W., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,349
Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds
Nassiri-Asl, M., & Hosseinzadeh, H. (2008) · Phytotherapy Research · doi:10.1002/ptr.2362 · Cited by 1,257
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
Cinátl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H. F., & Hw, D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13615-x · Cited by 1,175
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
Kim, Y.-J., & Uyama, H. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5054-y · Cited by 1,068
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects
Solano, F., Briganti, S., Picardo, M., & Ghanem, G. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00334.x · Cited by 697
Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue
Berube, B. J., & Wardenburg, J. B. (2013) · Toxins · doi:10.3390/toxins5061140 · Cited by 613
The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb
Wang, L., Yang, R., Yuan, B., Liu, Y., & Liu, C. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.05.005 · Cited by 602
Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin.
Isbrucker, R., & Burdock, G. (2006) · Regulatory toxicology and pharmacology : RTP · doi:10.1016/j.yrtph.2006.06.002 · Cited by 510
Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries
Parvez, S., Kang, M., Chung, H., & Bae, H. (2007) · Phytotherapy Research · doi:10.1002/ptr.2184 · Cited by 409
The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation.
Yokota, T., Nishio, H., Kubota, Y., & Mizoguchi, M. (1998) · Pigment Cell Research · doi:10.1111/j.1600-0749.1998.tb00494.x · Cited by 407
A history of the therapeutic use of liquorice in Europe
Fiore, C., Eisenhut, M., Ragazzi, E., Zanchin, G., & Armanini, D. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.015 · Cited by 382
The anti-inflammatory activity of licorice, a widely used Chinese herb
Yang, R.-H., Yuan, B.-C., Ma, Y.-S., Zhou, S., & Liu, Y. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1225775 · Cited by 375
Anti-Helicobacter pylori flavonoids from licorice extract
Fukai, T., Marumo, A., Kaitou, K., Kanda, T., Terada, S., & Nomura, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01864-7 · Cited by 367
Mechanisms regulating skin pigmentation: The rise and fall of complexion coloration
Ebanks, J. P., Wickett, R. R., & Boissy, R. E. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10094066 · Cited by 323
Flavonoids protect LDL from oxidation and attenuate atherosclerosis
Fuhrman, B., & Aviram, M. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200102000-00008 · Cited by 300
Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots
Nerya, O., Vaya, J., Musa, R., Izrael, S., Ben-Arie, R., & Tamir, S. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020935u · Cited by 297
Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions.
Wang, X.-Y., Zhang, H., Chen, L.-L., Shan, L., Fan, G.-W., & Gao, X.-M. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.09.055 · Cited by 285
Phytochemistry and biological properties of glabridin
Simmler, C., Pauli, G. F., & Chen, S.-N. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.07.003 · Cited by 281
glycyrrhizin as a potential treatment for chronic hepatitis C
van Rossum, T. G. J., Vulto, A. G., de Man, R. A., Brouwer, & Schalm (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00309.x · Cited by 270
Antimicrobial potential of Glycyrrhiza glabra roots
Gupta, V. K., Fatima, A., Faridi, U. A., Negi, A. S., Shanker, K., Kumar, J. K., Rahuja, N., Luqman, S., Sisodia, B. S., Saikia, D., et al. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.11.037 · Cited by 258
Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection
Chen, M., Theander, T. G., Christensen, S. B., Hviid, L., Zhai, L., & Kharazmi, A. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.7.1470 · Cited by 254
Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver
Yu, J.-Y., Ha, J., Kim, K.-M., Jung, Y.-S., Jung, J., & Oh, S. (2015) · Molecules · doi:10.3390/molecules200713041 · Cited by 253
Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata
Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y., & Kinoshita, T. (1998) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(97)10034-7 · Cited by 251
Flavonoid modulation of GABA A receptors
Hanrahan, J. R., Chebib, M., & Johnston, G. A. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01228.x · Cited by 246
Licorice abuse: time to send a warning message
Omar, H., Komarova, I., Elghonemi, M., Fathy, A., Rashad, R., Abdelmalak, H. D., Yerramadha, M. R., Ali, Y., Helal, E., & Camporesi, E. (2012) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018812454322 · Cited by 239
Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania
Chen, M., Christensen, S. B., Blom, J., Lemmich, E., Nadelmann, L., Fich, K., Theander, T. G., & Kharazmi, A. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.12.2550 · Cited by 221
Estrogen-like activity of glabrene and other constituents isolated from licorice root
Tamir, S., Eizenberg, M., Sömjen, D., Izrael, S., & Vaya, J. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00093-0 · Cited by 216
Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice
Fuhrman, B., Buch, S. J., Vaya, J., Belinky, P. A., Coleman, R., Hayek, T., & Aviram, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.267 · Cited by 206
Flavonoids: Antioxidants Against Atherosclerosis
Grassi, D., Desideri, G., & Ferri, C. (2010) · Nutrients · doi:10.3390/nu2080889 · Cited by 205
THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING†
Ploeger, B. A., Mensinga, T. T., Sips, A. J. A. M., Seinen, W., Meulenbelt, J., & DeJongh, J. (2001) · Drug Metabolism Reviews · doi:10.1081/dmr-100104400 · Cited by 203
Economic importance of licorice
Hayashi, H., & Sudo, H. (2009) · Plant Biotechnology · doi:10.5511/plantbiotechnology.26.101 · Cited by 202
A new exploration of licorice metabolome
Rizzato, G., Scalabrin, E., Radaelli, M., Capodaglio, G., & Piccolo, O. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.11.068 · Cited by 202
The treatment of atopic dermatitis with licorice gel
Saeedi, M., Morteza‐Semnani, K., & Ghoreishi, M. (2003) · Journal of Dermatological Treatment · doi:10.1080/09546630310014369 · Cited by 190
Therapeutic basis of glycyrrhizin on chronic hepatitis B
SATO, H., Goto, W., Yamamura, J., KUROKAWA, M., Kageyama, S., Takahara, T., Watanabe, A., & Shiraki, K. (1996) · Antiviral Research · doi:10.1016/0166-3542(96)00942-4 · Cited by 189
History of The Endocrine Effects of Licorice
Armanini, D., Fiore, C., Mattarello, M. J., Bielenberg, J., & Palermo, M. (2002) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2002-34587 · Cited by 188
Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in Rats
Huo, H., Wang, B., Liang, Y. K., Bao, Y. Y., & Gu, Y. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12106529 · Cited by 187
Medicinal plants with potential anti-arthritic activity:
Choudhary, M., Kumar, V., Malhotra, H., & Singh, S. (2015) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20150313021918 · Cited by 185
Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests
Dhingra, D., & Sharma, A. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.11.019 · Cited by 182
Evaluation of certain food additives.
Skovgaard, N. (1974) · PubMed · Cited by 176
Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells.
Tamir, S., Eizenberg, M., Sömjen, D., Stern, N., Shelach, R., Kaye, A. D., & Vaya, J. (2000) · PubMed · Cited by 173
Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
Michaelis, M., Geiler, J., Naczk, P., Sithisarn, P., Leutz, A., Doerr, H. W., & Cinatl, J. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019705 · Cited by 164
Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis
Xiao, X.-Y., Hao, M., Yang, X.-Y., Ba, Q., Li, M., Ni, S., Wang, L., & Du, X. (2011) · Cancer Letters · doi:10.1016/j.canlet.2010.12.016 · Cited by 164
Isoliquiritigenin Inhibits the Growth of Prostate Cancer
Kanazawa, M., Satomi, Y., Mizutani, Y., Ukimura, O., Kawauchi, A., Sakai, T., Baba, M., Okuyama, T., Nishino, H., & Miki, T. (2003) · European Urology · doi:10.1016/s0302-2838(03)00090-3 · Cited by 162
Antimicrobial activity of licorice flavonoids against methicillin-resistant Staphylococcus aureus
Fukai, T., Marumo, A., Kaitou, K., Kanda, T., Terada, S., & Nomura, T. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00168-5 · Cited by 156
Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid
Mahmoud, A. M., Hussein, O. E., Hozayen, W. G., & El-Twab, S. M. A. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.04.009 · Cited by 154
In Vitro and In Vivo Antiallergic Effects of Glycyrrhiza glabra and Its Components
Shin, Y.-W., Bae, E., Lee, B., Lee, S. W., Kim, J. H., Kim, Y.-S., & Kim, D.-H. (2007) · Planta Medica · doi:10.1055/s-2007-967126 · Cited by 141
Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves — Chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity
Siracusa, L., Saija, A., Cristani, M., Cimino, F., D’Arrigo, M., Trombetta, D., Rao, F., & Ruberto, G. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.01.009 · Cited by 139
Licorice Flavonoids Suppress Abdominal Fat Accumulation and Increase in Blood Glucose Level in Obese Diabetic KK-Ay Mice
Nakagawa, K., Kishida, H., Arai, N., Nishiyama, T., & Mae, T. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.1775 · Cited by 136
Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans
Messier, C., & Grenier, D. (2011) · Mycoses · doi:10.1111/j.1439-0507.2011.02028.x · Cited by 129
18β-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity
Lee, C. S., Kim, Y. J., Lee, M. S., Han, E. S., & Lee, S. J. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.07.014 · Cited by 127
Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang)
Kamei, J., Nakamura, R., Ichiki, H., & Kubo, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01728-x · Cited by 127
Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS
Hattori, T., Ikematsu, S., Koito, A., Matsushita, S., Maeda, Y., Hada, M., Fujimaki, M., & Takatsuki, K. (1989) · Antiviral Research · doi:10.1016/0166-3542(89)90035-1 · Cited by 127
Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells
Jung, J. W., Lim, S. S., Choi, H. J., CHO, H., Shin, H.-K., Kim, E. J., Chung, W., Park, K.-H., & Park, J. H. Y. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.006 · Cited by 126
Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries
Castangia, I., Caddeo, C., Manca, M. L., Casu, L., Catalán-Latorre, A., Dı́ez-Sales, O., Ruiz‐Saurí, A., Bacchetta, G., Fadda, A. M., & Manconi, M. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.08.037 · Cited by 122
Glycyrrhiza glabra (Liquorice) - a potent medicinal herb.
Joshi, M. (2014) · International Journal of Herbal Medicine · Cited by 121
Plants and other natural products used in the management of oral infections and improvement of oral health
Chinsembu, K. C. (2015) · Acta Tropica · doi:10.1016/j.actatropica.2015.10.019 · Cited by 116
A novel process for extraction of natural sweetener from licorice (Glycyrrhiza glabra) roots
Mukhopadhyay, M., & Panja, P. (2008) · Separation and Purification Technology · doi:10.1016/j.seppur.2008.06.013 · Cited by 116
18β‐glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF‐7 cells
Sharma, G., Kar, S., Palit, S., & Das, P. K. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22920 · Cited by 116
Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma
Yamazaki, S., Morita, T., Endo, H., Hamamoto, T., Baba, M., Joichi, Y., Kaneko, S., Okada, Y., Okuyama, T., Nishino, H., et al. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00113-1 · Cited by 116
Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells
Hsu, Y., Kuo, P., & Lin, C. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.09.047 · Cited by 114
In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites
Krausse, R. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh287 · Cited by 112
Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin
Račková, L., Jančinová, V., Petríková, M., Drábiková, K., Nosáľ, R., Štefek, M., Košťálová, D., Prónayová, N., & Kováčová, M. (2007) · Natural Product Research · doi:10.1080/14786410701371280 · Cited by 109
Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients
Sasaki, H., Takei, M., Kobayashi, M., Pollard, R. B., & Suzuki, F. (2002) · Pathobiology · doi:10.1159/000069334 · Cited by 108
Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor
Mendes‐Silva, W., Assafim, M., Ruta, B., Monteiro, R. Q., Guimarães, J. A., & Zingali, R. B. (2003) · Thrombosis Research · doi:10.1016/j.thromres.2003.10.014 · Cited by 103
In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action
Asha, M. K., Debraj, D., D’Souza, P., Edwin, J. R., Srikanth, H. S., Nithyanantham, M., Dethe, S., Bhaskar, A., Balachandran, J., Mundkinajeddu, D., et al. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.11.033 · Cited by 101
A polyphenolic flavonoid glabridin: Oxidative stress response in multidrug-resistant Staphylococcus aureus.
Singh, V., Pal, A., & Darokar, M. (2015) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2015.06.016 · Cited by 97
Evaluation of certain veterinary drug residues in food. Sixty-second report of the Joint FAO/WHO Expert Committee on food additives.
Fao, J. (2004) · PubMed · Cited by 96
Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage
Rajesh, M. G., & Latha, M. S. (2004) · TSpace (University of Toronto) · Cited by 95
Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms
Hajirahimkhan, A., Simmler, C., Yang, Y., Anderson, J. R., Chen, S., Nikolic, D. S., Dietz, B. M., Pauli, G. F., van Breemen, R. B., & Bolton, J. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067947 · Cited by 94
Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: An epigenetic regulation of miR-148a/SMAd2 signaling
Jiang, F., Li, Y., Mu, J., Hu, C., Zhou, M., Wang, X., Si, L., Ning, S., & Li, Z. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22333 · Cited by 92
New Dihydrostilbene Derivatives from the Leaves of Glycyrrhizaglabra and Evaluation of Their Antioxidant Activity
Biondi, D. M., Rocco, C., & Ruberto, G. (2003) · Journal of Natural Products · doi:10.1021/np020365s · Cited by 89
Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats
Karahan, F., Avşar, C., Özyiğit, İ. İ., & Berber, İ. (2016) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2016.1179590 · Cited by 88
Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models An experimental study
Chakravarthi, K., & Avadhani, R. (2013) · Journal of Natural Science Biology and Medicine · doi:10.4103/0976-9668.117025 · Cited by 87 · cited 2×
“Chakravarthi and Avadhani (2013) and Dhingra and Sharma (2006) studied the effects of G. glabra root aqueous extract on the learning and memory of 1month-old male Wistar albino mice at doses between 75 and 300 mg/kg, orally administered during six successive weeks.”
Background
Two antimicrobial flavanones from the leaves of Glycyrrhiza glabra.
Fukui, H., GOTO, K., & Tabata, M. (1988) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.36.4174 · Cited by 87
Evaluation of immunomodulatory activity of Glycyrhiza glabra L roots in combination with zing
Mazumder, P. M., Pattanayak, S. P., Parvani, H., Sasmal, D., & Rathinavelusamy, P. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60122-1 · Cited by 87
Anti-HIV activity of Indian medicinal plants
Sabde, S., Bodiwala, H. S., Karmase, A., Deshpande, P. J., Kaur, A., Ahemad, N., Chauthe, S. K., Brahmbhatt, K. G., Phadke, R. U., Mitra, D., et al. (2011) · Journal of Natural Medicines · doi:10.1007/s11418-011-0513-2 · Cited by 85
A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements
Powers, C. N., & Setzer, W. N. (2015) · In Silico Pharmacology · doi:10.1186/s40203-015-0008-z · Cited by 84
Antidiabetic Effect of Glycyrrhizin in Genetically Diabetic KK-Ay Mice.
Takii, H., Kometani, T., Nishimura, T., Nakae, T., Okada, S., & Fushiki, T. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.484 · Cited by 84
Topical agents used in the management of hyperpigmentation.
Halder, R. M., & Richards, G. M. (2004) · PubMed · Cited by 83
Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus.
Wu, F.-H., Jin, Z., & Jin, J. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1330 · Cited by 82
Hypnotic effects and binding studies for GABAA and 5-HT2C receptors of traditional medicinal plants used in Asia for insomnia
Cho, S.-M., Shimizu, M., Lee, C. J., Han, D.-S., Jung, C.-K., Jo, J.-H., & Kim, Y.-M. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.009 · Cited by 80
Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice
Ahn, J., Lee, H., Jang, J., Kim, S., & Ha, T. Y. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.08.048 · Cited by 75
Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus
Oyama, K., Kawada-Matsuo, M., Oogai, Y., Hayashi, T., Nakamura, N., & Komatsuzawa, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165831 · Cited by 75
The Efficacy of Licorice Root Extract in Decreasing Transaminase Activities in Non‐alcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial
Hajiaghamohammadi, A. A., Ziaee, A., & Samimi, R. (2012) · Phytotherapy Research · doi:10.1002/ptr.3728 · Cited by 75
PHYTOCHEMICAL SCREENING AND DETERMINATION OF ANTI-BACTERIAL AND ANTI-OXIDANT POTENTIAL OF Glycyrrhiza glabra ROOT EXTRACTS
Sharma, V., Agrawal, R. C., & Sonam, P. (2013) · Cited by 75
Antifungal Activity of Plant Extracts against Arthrinium sacchari and Chaetomium funicola.
Sato, J., Goto, K., Nanjo, F., Kawai, S., & Murata, K. (2000) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(01)80016-5 · Cited by 74
Effects of phytoestrogen on sexual development
Kim, S. H., & Park, M. J. (2012) · Korean Journal of Pediatrics · doi:10.3345/kjp.2012.55.8.265 · Cited by 74
Effects of Glycyrrhizin in a Mouse Model of Lung Adenocarcinoma
Deng, Q.-P., Wang, M., Zeng, X. Z., Chen, G. G., & Huang, R.-Y. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000467897 · Cited by 73
Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not
Lee, J. Y., Lee, J.-H., Park, J. H., Kim, S., Choi, J. Y., Lee, S. H., Kim, Y. S., Kang, S. S., Jang, E., & Han, Y. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.02.007 · Cited by 73
Glabridin as a major active isoflavan fromGlycyrrhiza glabra(licorice) reverses learning and memory deficits in diabetic rats
Hasanein, P. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.2.14 · Cited by 67
A review of the health effects and uses of drugs of plant licorice (Glycyrrhiza glabra L.) in Iran
Bahmani, M., Rafieian‐Kopaei, M., Jeloudari, M., Eftekhari, Z., Delfan, B., Zargaran, A., & Forouzan, S. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60742-8 · Cited by 66
Glycyrrhizin inhibits LPS-induced inflammatory mediator production in endometrial epithelial cells
Wang, X., Hao, H.-G., & Chu, L. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.05.032 · Cited by 61
Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection
van Rossum, T. G. J., Vulto, A. G., Hop, W. C. J., & Schalm, S. W. (1999) · Clinical Therapeutics · doi:10.1016/s0149-2918(00)87239-2 · Cited by 59
18β-Glycyrrhetinic Acid Ameliorates Acute Propionibacterium acnes-induced Liver Injury through Inhibition of Macrophage Inflammatory Protein-1α
Xiao, Y., Xu, J., Mao, C., Jin, M., Wu, Q. D., Zou, J., Gu, Q., Zhang, Y., & Zhang, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.037705 · Cited by 59
Alternative to antibiotics against Pseudomonas aeruginosa: Effects of Glycyrrhiza glabra on membrane permeability and inhibition of efflux activity and biofilm formation in Pseudomonas aeruginosa and its in vitro time-kill activity
Chakotiya, A. S., Tanwar, A., Narula, A., & Sharma, R. K. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.07.001 · Cited by 59
Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues
Sömjen, D., Katzburg, S., Vaya, J., Kaye, A. M., Hendel, D., Posner, G. H., & Tamir, S. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.04.008 · Cited by 58
Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous carcinoma FaDu cells
Park, M., Kim, S.-G., Cho, I., Oh, D., Kang, K.-R., Lee, S., Moon, S., Cho, S., Yoon, G., Kim, C. S., et al. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.12.013 · Cited by 58
18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration
Wang, S., Shen, Y., Qiu, R., Chen, Z., Chen, Z., & Chen, W. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4059 · Cited by 58
Glabridin induces oxidative stress mediated apoptosis like cell death of malaria parasite Plasmodium falciparum
Cheema, H. S., Prakash, O., Pal, A., Khan, F., Bawankule, D. U., & Darokar, M. P. (2013) · Parasitology International · doi:10.1016/j.parint.2013.12.005 · Cited by 57
Metabolites identification of bioactive licorice compounds in rats
Wang, Q., Yi, Q., Wang, Q., Yang, Y., Ji, S., Song, W., Qiao, X., Guo, D., Liang, H., & Ye, M. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.08.013 · Cited by 57
Glabridin induces apoptosis and autophagy through JNK1/2 pathway in human hepatoma cells
Hsieh, M., Chen, M., Chen, C., Hsieh, M., Lo, Y., Chuang, Y., Chiou, H., & Yang, S. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.005 · Cited by 56
Chemopreventive effect of 18β-glycyrrhetinic acid via modulation of inflammatory markers and induction of apoptosis in human hepatoma cell line (HepG2)
Hasan, S. K., Siddiqi, A., Nafees, S., Ali, N., Rashid, S., Ali, R., Shahid, A., & Sultana, S. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2705-2 · Cited by 56
Memory-Strengthening Activity of Glycyrrhiza glabra in Exteroceptive and Interoceptive Behavioral Models
Parle, M., Dhingra, D., & Kulkarni, S. K. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.462 · Cited by 54
Metabolomics Analysis To Evaluate the Anti-Inflammatory Effects of Polyphenols: Glabridin Reversed Metabolism Change Caused by LPS in RAW 264.7 Cells
Liu, K., Pi, F., Zhang, H., Ji, J., Xia, S., Cui, F., Sun, J., & Sun, X. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01692 · Cited by 54
18β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model
Kim, S., Hong, J.-H., Lee, J., & Lee, Y. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.03.011 · Cited by 53
Antiviral and immune stimulant activities of glycyrrhizin against duck hepatitis virus
Soufy, H., Yassein, S., Ahmed, A., Khodier, M. H., Kutkat, M. A. A., Nasr, S. M., & Okda, F. A. (2012) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v9i3.14 · Cited by 52
Glycyrrhizin increases survival of mice with herpes simplex encephalitis.
Sekizawa, T., YANAGI, K., & Itoyama, Y. (2001) · PubMed · Cited by 51
Efficacy of Intravenous Glycyrrhizin in the Early Stage of Acute Onset Autoimmune Hepatitis
Yasui, S., Fujiwara, K., Tawada, A., Fukuda, Y., Nakano, M., & Yokosuka, O. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1789-5 · Cited by 51
Antioxidant effect of polyphenolic glabridin on LDL oxidation
Carmeli, E., & Fogelman, Y. (2009) · Toxicology and Industrial Health · doi:10.1177/0748233709103034 · Cited by 49
Licorice (Glycyrrhiza Glabra Linn) as a Valuable Medicinal Plant
Zadeh, J. B., Kor, Z. M., & Goftar, M. K. (2013) · International Journal of Advanced Biological and Biomedical Research · Cited by 49
Glycyrrhizin inhibits porcine epidemic diarrhea virus infection and attenuates the proinflammatory responses by inhibition of high mobility group box-1 protein
Huan, C., Wang, H.-X., Sheng, X.-X., Wang, R., Wang, X., & Mao, X. (2017) · Archives of Virology · doi:10.1007/s00705-017-3259-7 · Cited by 49
Inhibition of Intercellular Adhesion in Herpex Simplex Virus Infection by Glycyrrhizin
Huang, W., Chen, X., Li, Q., Li, P., Zhao, G., Xu, M., & Xie, P. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9271-8 · Cited by 48
Anti-arthritic activity of Glycyrrhiza glabra, Boswellia serrata and their synergistic activity in combined formulation studied in freund's adjuvant induced arthritic rats
Bstia, S., Mishra, G., & Patra, S. K. (2011) · Cited by 48
Potentiating Effect of Glabridin on GABAA Receptor-Mediated Responses in Dorsal Raphe Neurons
Jin, Z., Kim, S., Cho, S., Kim, I.-H., Han, D., & Jin, Y. (2013) · Planta Medica · doi:10.1055/s-0033-1350698 · Cited by 41
Glycyrrhiza glabra protects from myocardial ischemia–reperfusion injury by improving hemodynamic, biochemical, histopathological and ventricular function
Ojha, S. K., Golechha, M., Kumari, S., Bhatia, J., & Arya, D. S. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.08.011 · Cited by 40
Effect of aquo-alchoholic extract of Glycyrrhiza glabra against Pseudomonas aeruginosa in Mice Lung Infection Model
Chakotiya, A. S., Tanwar, A., Srivastava, P., Narula, A., & Sharma, R. K. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.055 · Cited by 38
Estimation of dietary intake of ochratoxin A from liquorice confectionery
Herrera, M., Herrera, A., & Ariño, A. A. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.05.009 · Cited by 37
Glycyrrhiza Glabra: Chemistry and Pharmacological Activity
Sharma, V., Katiyar, A., & Agrawal, R. C. (2016) · Reference series in phytochemistry · doi:10.1007/978-3-319-26478-3_21-1 · Cited by 37
Glycyrrhizin Administration Ameliorates Coxsackievirus B3-Induced Myocarditis in Mice
Zhang, H., Song, Y., & Zhang, Z. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31823e2867 · Cited by 36
Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d -galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M
Yin, X., Gong, X., Zhang, L. R., Jiang, R., Kuang, G., Wang, B., Chen, X., & Wan, J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.02.011 · Cited by 35
Water Extract ofGlycyrrhiza uralensisInhibited Enterovirus 71 in a Human Foreskin Fibroblast Cell Line
Kuo, K., Chang, J., Wang, K.-C., & Chiang, L. (2009) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x09006904 · Cited by 35
Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model
Paola, R. D., Menegazzi, M., Mazzon, E., Genovese, T., Crisafulli, C., Bosco, M. D., Zou, Z., Suzuki, H., & Cuzzocrea, S. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1334-y · Cited by 34
18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways
Huang, Y.-C., Kuo, C., Lu, K.-W., Lin, J., Yang, J.-L., Wu, R. S.-C., Wu, P.-P., & Chung, J. (2016) · Molecules · doi:10.3390/molecules21070872 · Cited by 34
18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures.
Veratti, E., Rossi, T., Giudice, S., Benassi, L., Bertazzoni, G., Morini, D., Azzoni, P., Bruni, E., Giannetti, A., & Magnoni, C. (2011) · PubMed · Cited by 33
Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
Li, Y., Feng, L., Song, Z.-F., Li, H., & Huai, Q. (2016) · Molecules · doi:10.3390/molecules21020199 · Cited by 32
The Protective Effects of 18β-Glycyrrhetinic Acid onHelicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils
Cao, D., Jiang, J., You, L., Jia, Z., Tsukamoto, T., Cai, H., Wang, S., Hou, Z., Suo, Y.-E., & Cao, X. (2016) · BioMed Research International · doi:10.1155/2016/4943793 · Cited by 31
Estrogenicity of Glabridin in Ishikawa Cells
Poh, M. S. W., Yong, P. V. C., Viseswaran, N., & Chia, Y. Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121382 · Cited by 29
Effect of aqueous and alcoholic licorice (glycyrrhiza glabra) root extract against streptococcus mutans and lactobacillus acidophilus in comparison to chlorhexidine: an in vitro study.
Ajagannanavar, S. L., Battur, H., Shamarao, S., Sivakumar, V., Patil, P. U., & Shanavas, P. (2014) · PubMed Central · Cited by 29
Role of Glucocorticoid in the Development of Glycyrrhizin-Induced Hypertension
Kageyama, Y., Suzuki, H., & Saruta, T. (1994) · Clinical and Experimental Hypertension · doi:10.3109/10641969409078024 · Cited by 28
Screening of phytochemical, antimicrobial and antioxidant activity of Glycyrrhiza glabra root extract
Chandra, J. H., & Gunasekaran, H. (2017) · Journal of Environmental Biology · doi:10.22438/jeb/38/1/mrn-441 · Cited by 27
Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways
Yu, S., Cho, I., Kang, K.-R., Jung, Y.-R., Cho, S., Yoon, G., Oh, J., You, J., Seo, Y.-S., Lee, G., et al. (2017) · Oncology Letters · doi:10.3892/ol.2017.5865 · Cited by 26
Clinical trial of deglycyrrhizinised liquorice in gastric ulcer.
Bardhan, K. D., Cumberland, D. C., Dixon, R. A., & Holdsworth, C. D. (1978) · Gut · doi:10.1136/gut.19.9.779 · Cited by 26
IN VITRO SUSCEPTIBILITY OF HELICOBACTER PYLORI TO LICORICE EXTRACT
Jafarian, M., & Ghazvini, K. (2010) · Iranian journal of pharmaceutical research · doi:10.22037/ijpr.2010.701 · Cited by 25
Glabridin triggers over-expression of MCA1 and NUC1 genes in Candida glabrata: Is it an apoptosis inducer?
Moazeni, M., Hedayati, M. T., Nabili, M., Mousavi, S. J., Gohar, A. A., & Gholami, S. (2017) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2017.05.002 · Cited by 25
In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity
Sharma, V., & Agrawal, R. (2014) · International Journal of Research in Medical Sciences · doi:10.5455/2320-6012.ijrms20140260 · Cited by 23
Two activators of in vitro fertilization in mice from licorice
Tùng, N. H., Shoyama, Y., Wada, M., & Tanaka, H. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.088 · Cited by 21
Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality
Albermann, M. E., Mußhoff, F., Hagemeier, L., & Madea, B. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2009.12.018 · Cited by 21
Chemical Composition and Antimicrobial Activities of the Essential Oil fromGlycyrrhiza glabraLeaves
Chouitah, O., Meddah, B., Aoues, A., & Sonnet, P. (2011) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2011.10643935 · Cited by 20
Formulation and evaluation of floating tablets of liquorice extract
Ram, H. A., Lachake, P., Kaushik, U., & Shreedhara, C. S. (2010) · Pharmacognosy Research · doi:10.4103/0974-8490.72329 · Cited by 20
Protective effects of hepatocyte-specific glycyrrhetic derivatives against carbon tetrachloride-induced liver damage in mice
Yang, Y. K., Yang, L., Han, Y., Wu, Z., Chen, P., Zhang, H., & Zhou, J. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.03.009 · Cited by 20
Potentiating effect of glabridin from Glycyrrhiza glabra on GABA A receptors
Hoffmann, K. M., Beltrán, L. R., Ziemba, P. M., Hatt, H. H., & Gisselmann, G. (2016) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.04.007 · Cited by 20
Biphasic calcium phosphate–casein bone graft fortified with Cassia occidentalis for bone tissue engineering and regeneration
Kumar, B. S., Hemalatha, T., Deepachitra, R., Raghavan, R. N., Periyathambi, P., & Sastry, T. P. (2015) · Bulletin of Materials Science · doi:10.1007/s12034-014-0799-2 · Cited by 19
Assessment of median lethal dose and anti-mutagenic effects of Glycyrrhiza glabra root extract against chemically induced micronucleus formation in Swiss albino mice
Sharma, V., Agrawal, R. C., & Shrivastava, V. K. (2014) · International Journal of Basic & Clinical Pharmacology · doi:10.5455/2319-2003.ijbcp20140407 · Cited by 19
Glabridin protects osteoblastic MC3T3-E1 cells against antimycin A induced cytotoxicity
Choi, E. M. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.05.007 · Cited by 18
Anti-arthritic activity of Glycyrrhiza glabra, Boswellia serrata and their synergistic activity in combined formulation studied in freund's adjuvant induced arthritic rats
Mishra, N. K., Bstia, S., Mishra, G., Chowdary, K. A., & Patra, S. (2011) · doi:10.13140/rg.2.2.25257.36961 · Cited by 18
Determination of optimal concentration of deglycyrrhizinated licorice root extract for preventing dental caries using a bacterial model system
Ahn, S., Song, Y.-D., Mah, S., Cho, E., & Kook, J. (2014) · Journal of Dental Sciences · doi:10.1016/j.jds.2014.03.005 · Cited by 17
Antiandrogenic activities of Glycyrrhiza glabra in male rats
Zamansoltani, F., Nassiri‐Asl, M., Sarookhani, M. R., Jahanihashemi, H., & Zangivand, A. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00944.x · Cited by 15
Improved In Vitro Fertilization Ability of Mouse Sperm Caused by the Addition of Licorice Extract to the Preincubation Medium
Tung, N. H., Shoyama, Y., Wada, M., & Tanaka, H. (2014) · The Open Reproductive Science Journal · doi:10.2174/1874255601406010001 · Cited by 14
The stimulatory and inhibitory effects of glycyrrhizin and a glycyrrhetinic acid derivative on phosphorylation of lipocortin I by A-kinase in vitro.
Ohtsuki, K., Oh-Ishi, M., & Nagata, N. (1992) · PubMed · Cited by 13
Effects of topical application of B‐Resorcinol and Glycyrrhetinic acid monotherapy and in combination with fractional CO2 laser treatment for benign hand hyperpigmentation treatment
Grippaudo, F. R., & Russo, P. P. D. (2016) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12241 · Cited by 13
Field Survey of Glycyrrhiza Plants in Central Asia (4). Characterization of G. glabra and G. bucharica Collected in Tajikistan
Hayashi, H., Tamura, S., Chiba, R., Fujii, I., Yoshikawa, N., Fattokhov, I., & Saidov, M. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00251 · Cited by 11
Intestinal absorption and biliary elimination of glycyrrhizic acid diethyl ester in rats
Koga, K., Kawamura, M., Iwase, H., & Yoshikawa, N. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s51638 · Cited by 10
Detection of consensuses and treatment principles of diabetic nephropathy in traditional Chinese medicine: A new approach
Xu, T., Xie, Q., Rong, G., Zhou, S., & Meng, Q. (2015) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2016.02.001 · Cited by 7
Successful treatment of latent autoimmune diabetes in adults with Traditional Chinese Medicine: a case report
Tian, J., Liu, W., Zhong, Z., & Tong, X. (2013) · 中医杂志：英文版 · doi:10.1016/s0254-6272(14)60010-8 · Cited by 6

Flagged first, then by citations

2 of the 157 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

FAO, 2005, Sixty‐third report of the Joint FAO/WHO Expert Committee on Food Additives
Harwansh R. K., 2011, Pharmacological studies of Glycyrrhiza glabra: A review, Pharmacology, 2, 1032
10.4103/0976-4836.72329 · DOI
Saumendu D. R., 2014, Hair growth stimulating effect and phytochemical evaluation of hydro‐alcoholic extract of Glycyrrhiza glabra, Global Journal of Research on Medicinal Plants & Indigenous Medicine, 3, 40
Shalaby A. M., 2004, Some effects of Glycyrrhiza glabra (liquorice) roots extract on male rats, Egyptian Journal of Natural Toxins, 1, 83

Sorted by citations

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)
Batiha, G. E., Beshbishy, A. M., El‐Mleeh, A., Abdel‐Daim, M. M., & Devkota, H. P. (2020) · Biomolecules · doi:10.3390/biom10030352 · Cited by 488
Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
Wahab, S., Annadurai, S., Abullais, S. S., Das, G., Ahmad, W., Ahmad, M. F., Kandasamy, G., Vasudevan, R., Ali, S., & Amir, M. (2021) · Plants · doi:10.3390/plants10122751 · Cited by 455
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals
Juncan, A. M., Moisă, D. G., Santini, A., Morgovan, C., Rus, L. L., Vonica-Țincu, A. L., & Loghin, F. (2021) · Molecules · doi:10.3390/molecules26154429 · Cited by 395
A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective
Chassagne, F., Samarakoon, T., Porras, G., Lyles, J. T., Dettweiler, M., Marquez, L., Salam, A. M., Shabih, S., Farrokhi, D. R., & Quave, C. L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.586548 · Cited by 306
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?
Bailly, C., & Vergoten, G. (2020) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2020.107618 · Cited by 261

See all 831

Authors: Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P.
Affiliations: University of Genoa (IT)
National Research Council (IT)
Universidade do Porto (PT)
Corresponding author: Rodrigues, Francisca
ORCID: Cornara, Laura
Soares, Sónia
Rodrigues, Francisca
Oliveira, M. Beatriz P.P.
Venue: Phytotherapy Research
Publisher: Wiley
Published: 2018-08-17
Volume: 32
Issue: 12
Pages: 2323-2339
ISSN: 0951-418X (ISSN-L)
1099-1573
DOI: 10.1002/ptr.6178
PMC: PMC7167772
OpenAlex: W2886070608
Cited by: 804
References: 157
Citations by year: 2026: 103 · 2025: 122 · 2024: 143 · 2023: 114 · 2022: 129 · 2021: 103 · 2020: 67 · 2019: 21 · 2018: 1
FWCI: 9.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Phytotherapy Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Funders: Ministério da Educação e Ciência
Fundação para a Ciência e a Tecnologia (Operação NORTE‐01‐0145‐FEDER‐000011)
European Regional Development Fund (NORTE‐01‐0145‐FEDER‐000011)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: licorice, phytochemicals, glycyrrhizin, 18β-glycyrrhetinic acid, isoflavones, antibacterial activity, anti-inflammatory activity, antiviral activity, antioxidant activity, antidiabetic activity, toxicity, ethnopharmacology, nutraceuticals, traditional medicine
MeSH terms: Animals, Anti-Bacterial Agents, Antioxidants, Antiviral Agents, Enzyme Inhibitors, Glycyrrhiza, Humans, Hypoglycemic Agents, Medicine, Traditional, Plant Extracts, Glycyrrhizic Acid, Ethnopharmacology, Phytochemicals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks