Piperine: A review of its biological effects

Prevalence of Obesity Among Adults and Youth: United States, 2015-2016.

Hales, C. M., Carroll, M. D., Fryar, C. D., & Ogden, C. L. (2017) · PubMed · Cited by 3,884

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,656

Immunomodulatory and antitumor activity of Piper longum Linn. and piperine

Sunila, E. S., & Kuttan, G. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.10.016 · Cited by 539

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G., & Wicha, M. S. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0612-x · Cited by 503

Fenaroli's Handbook of Flavor Ingredients

Burdock, G. A. (2001) · CRC Press eBooks · doi:10.1201/noe0849309465 · Cited by 490

Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Majeed, M. A., & Sahebkar, A. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2014.12.019 · Cited by 407

Biological role of Piper nigrum L. (Black pepper): A review

Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60524-3 · Cited by 377

Piper nigrum and Piperine: An Update

Meghwal, M., & Goswami, T. K. (2013) · Phytotherapy Research · doi:10.1002/ptr.4972 · Cited by 366

Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

Elnaggar, Y. S. R., Etman, S. M., Abdelmonsif, D. A., & Abdallah, O. Y. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24557 · Cited by 327

In vitro modulation the Notch pathway by piperine: A therapeutic strategy for docetaxel‐resistant and non‐resistant prostate cancer

Wang, R.-T., Liu, H., & Sun, H. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14562 · Cited by 6

Antibacterial and anti-biofilm efficacy of 1,4-naphthoquinone against Chromobacterium violaceum: an in vitro and in silico investigation

Samreen, S., & Ahmad, I. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04209-8 · Cited by 6

Piperine Enhances Mitochondrial Biogenesis to Mitigate Stress in SH ‐ SY5Y Neuroblastoma Cells

Saikachain, N., Charoensawat, P., Tuntoolavest, O., Vejsureeyakul, N., Kunpittaya, T., Poolsri, W., Sungkaworn, T., Saeeng, R., Muanprasat, C., & Asavapanumas, N. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70637 · Cited by 6

Cytotoxicity and Gene Expression Studies of Curcumin and Piperine Loaded Nanoparticles on Breast Cancer Cells

Jafari, D. A., Başpınar, Y., Üstündaş, M., Bayraktar, O., Kara, H. G., & Sezgin, C. (2022) · Russian Journal of Applied Chemistry · doi:10.1134/s1070427222010177 · Cited by 6

Piperine as potential therapy of post-weaning porcine diarrheas: an in vitro study using a porcine duodenal enteroid model

Satitsri, S., Akrimajirachoote, N., Nunta, K., Ruennarong, N., Amnucksoradej, O., & Muanprasat, C. (2023) · BMC Veterinary Research · doi:10.1186/s12917-022-03536-6 · Cited by 6

The interactive effect of seven weeks aerobic exercise training and piperine against paraquat-induced lung damage in male Wistar rats: Investigating role of oxidative and inflammatory indices

Ariyanasab, R., Askari, V. R., Askari, R., Rahimi, V. B., Hejazi, K., & Asadi, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33241 · Cited by 6

Assessment of Production Performance and Egg Quality of Commercial Laying Hens Fed Black Pepper and Red Pepper Additives

Aikpitanyi, K. U., & Imasuen, J. A. (2023) · European Journal of Veterinary Medicine · doi:10.24018/ejvetmed.2023.3.3.89 · Cited by 6

Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients

Wahono, C. S., Susianti, H., Hakim, A. L., Rosita, F., Pratama, M. Z., Rahman, P. A., & Anshory, M. (2024) · Current Rheumatology Reviews · doi:10.2174/0115733971276106231226071002 · Cited by 6

Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice

Zhang, L., Kuang, G., Gong, X., Huang, R., Zhao, Z., Li, Y., Wan, J., & Wang, B. (2024) · Transplant Immunology · doi:10.1016/j.trim.2024.102033 · Cited by 6

Survivin Interference and SurVaxM as an Adjunct Therapy for Glioblastoma Multiforme

Elliott, W. J., Gurramkonda, N., Guda, M. R., Tsung, A. J., & Velpula, K. K. (2025) · Cells · doi:10.3390/cells14100755 · Cited by 5

Evaluation of methanolic extracts from five important medicinal plants: Phytochemical profiling, antioxidant capacity, in vitro antidiabetic activity, and cytotoxicity assay

Ahmed, M. S., Hasan, M. M.-U., Ahmmed, R., Bismillah, M., Rahman, M. A., Hossain, M. I., Khan, M. H., & Islam, M. A. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.07.013 · Cited by 5

Flavonoids in the treatment of Leishmania amazonensis: a review of efficacy and mechanisms

Lessa, V. L., Drescher, G., Gonçalves, G., Lopes, J. C., Vieira, R. F. D. C., & Figueiredo, F. B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1642005 · Cited by 5

A comprehensive study on the effects of drying methods on the color, structure, flavor, and nutritional properties of green peppers (Piper nigrum L.)

Wang, X., Su, H. L., Gao, R., Li, H., Lyu, Y., Chen, H., Zhong, Q., He, R., Li, C., & Chen, W. (2025) · Food Chemistry X · doi:10.1016/j.fochx.2025.103183 · Cited by 5

Immunomodulatory Potential of Piperine in Rats

Ghavami, A., Froushani, S. M. A., & Tehrani, A. (2024) · Turkish Journal of Immunology · doi:10.4274/tji.galenos.2024.20082 · Cited by 5

Piperine as an Herbal Alternative for the Prevention of Drug-Induced Liver Damage Caused by Paracetamol

Coelho, A. M., Queiroz, I. F., Perucci, L. O., Menezes, T. P., de Lima, W. G., Talvani, A., & Costa, D. C. (2024) · Pharmaceuticals · doi:10.3390/ph17111477 · Cited by 5

Radioprotective Effect of Piperine, as a Major Component of Black Pepper, Against Radiation-induced Colon Injury: Biochemical and Histological Studies

Safarbalou, A., Ebrahimi, F., Amiri, F. T., & Hosseinimehr, S. J. (2023) · Current Radiopharmaceuticals · doi:10.2174/1874471016666230725112319 · Cited by 5

Biochemical characterization of bioinspired nanosuspensions from Swertia chirayita extract and their therapeutic effects through nanotechnology approach

Raza, A., Ali, T., Naeem, M., Asim, M. A., Hussain, F., Li, Z., & Nasır, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0293116 · Cited by 5

Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect

Lee, H., Lee, J.-H., Baek, J., Cho, K. A., & Min, K. (2024) · Biogerontology · doi:10.1007/s10522-024-10100-2 · Cited by 5

Piperine enhances contractile force in slow‐ and fast‐twitch muscle

Herskind, J., Ørtenblad, N., Cheng, A. J., Pedersen, P., & Overgaard, K. (2024) · The Journal of Physiology · doi:10.1113/jp285995 · Cited by 5

Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer

Asoka, A. S., Kolikkandy, A., Nair, B., Kamath, A. J., Sethi, G., & Nath, L. R. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300793 · Cited by 5

Antioxidant profile, and fatty acids analysis of leaves of medicinal plant Piper chaba H. (Chuijhal): a promising source of antioxidant and fatty acids

Shandhi, S. P. (2024) · Vegetos · doi:10.1007/s42535-024-00898-0 · Cited by 5

Synthesis and antiproliferative evaluation of new hybrids of piperine and acylhydrazone

Xu, S.-K., Jia, Z.-M., Liu, W., Gu, Y.-Z., Xi, J.-H., Xu, J., Yang, G., Yang, X., & Chen, Y. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2391083 · Cited by 5

Combination of a Natural Bioactive Compound and High-Hydrostatic-Pressure Treatment to Increase the Shelf-Life and Quality of Pork Meat

Csurka, T., Fekete, Z., Visy, A., Hidas, K. I., Dalmadi, I., Horváth, F., Friedrich, L., & Jónás, G. (2024) · Applied Sciences · doi:10.3390/app14188212 · Cited by 5

Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway

Gao, W., Wang, D., Shi, Y., Sun, Y. H., Deng, J., Song, X., Zhang, M., & Li, J. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073331615241018081811 · Cited by 5

State of the art progress of Evolvulus alsinoides in pharmacological activity and plant tissue culture: A potent Chinese medicinal plant

Awere, C. O., Anadebe, V. C., Rakkammal, K., Muthuramalingam, P., & Manikandan, R. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100586 · Cited by 5

Herbs and Spices - New Perspectives in Human Health and Food Industry

Ivanišová, E. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1001733 · Cited by 4

A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

Majeed, A., Majeed, S., Parameswarappa, A. K., Murali, A., Gudimallam, S., Siddegowda, C., Chandrashekar, H., & Mundkur, L. (2024) · Medicine · doi:10.1097/md.0000000000039243 · Cited by 4

Piperine Prevents Scopolamine-Induced Cognitive Impairment via its Antioxidant and Anti-Inflammatory Roles; Suggesting Potential Modulation of Necroptosis-Related Genes Including MLKL and TNF-α

Kopi, T. A., Shanehbandpour-Tabari, F., Arani, R. M., Ataie, A., Pouramir, M., & Khaleghzadeh‐Ahangar, H. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02437-1 · Cited by 4

Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid

Shi, F., Li, R., Wang, W., Yu, X., Zhu, F., Huang, Y., Wang, J., & Zhang, Z. (2023) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2023.2182120 · Cited by 4

Phosphomolybdic Acid‐Catalyzed One‐Pot Multicomponent Synthesis of 1,2,5,6‐Tetrahydropyridine Derivatives

Palermo, V., Castillo, J., Macias, M. A., Martínez, J. J., Langer, P., & Romanelli, G. P. (2024) · ChemistrySelect · doi:10.1002/slct.202403739 · Cited by 4

Ethanolic Fruit Extract of Piper Retrofractum Induced Cell Cycle Arrest, Apoptosis, Increased Reactive Oxygen Species Production, and Mitochondrial Dysfunction in Human Cervical Cancer

Chaisri, P., Laoprom, N., & Buranrat, B. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402353 · Cited by 4

Impact of fat level on piperine’s cross-modal interaction on saltiness perception

Moss, R. H., Gorman, M., Stright, A., Frampton, K., Dabas, T., Dolan, E., & McSweeney, M. B. (2024) · Food and Humanity · doi:10.1016/j.foohum.2024.100473 · Cited by 4

Investigating the microwave parameters correlating effects on total recovery of bioactive alkaloids from sesame leaves using orthogonal matrix and artificial neural network integration

Olalere, O. A., Gan, C., Taiwo, A. E., Alenezi, H., Maqsood, S., & Adeyi, O. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16591 · Cited by 4

The detection and modulation of piperine in the human oral cavity

Smutzer, G., Lee, E., Shahshahani, S., Puwar, V., & Wilson, J. G. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114448 · Cited by 4

The Potential Radioprotective Effect of Piperine against Radiation-induced Lung Injury in Mice: Histopathological and Biochemical Evaluations

Safarbalou, A., Ebrahimi, F., Amiri, F. T., & Hosseinimehr, S. J. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128296224240530060011 · Cited by 4

Transcriptomic Analysis of the Protective Effect of Piperine on Orlistat Hepatotoxicity in Obese Male Wistar Rats

Ledesma‐Aparicio, J., Mailloux‐Salinas, P., Arias‐Chávez, D. J., Campos‐Pérez, E., Calixto-Tlacomulco, S., Cruz‐Rangel, A., Reyes‐Grajeda, J. P., & Bravo, G. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70040 · Cited by 4

Spongosome-based co-delivery of curcumin and Piperine: A novel strategy for mitigating pollution-induced skin damage

Bondi, A., Ferrara, F., Pula, W., Mariani, P., Pepe, A., Drechsler, M., Montesi, L., Manfredini, S., Valacchi, G., & Esposito, E. (2024) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2024.100811 · Cited by 4

Molecular dynamics simulation-driven focused virtual screening and experimental validation of Fisetin as an inhibitor of Helicobacter pylori HtrA protease

Gao, L., Jiang, X., Duan, H., Shen, Y., Gu, K., Huang, K., Wang, Y., Mao, S., Zhang, R., & Lin, Z. (2025) · Molecular Diversity · doi:10.1007/s11030-025-11137-2 · Cited by 4

Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Huang, L., Zhong, X., Zhou, Z., Cai, Y., & Deng, M. (2022) · Applied Biological Chemistry · doi:10.1186/s13765-022-00710-0 · Cited by 4

Trikatu, a Thai Ayurvedic Remedy of Piper nigrum, Piper retrofractum, and Zingiber officinale Promotes Anti-cholangiocarcinoma Cell Proliferation via Cell Cycle Arrest

Nakasen, K., Sriraj, P., Prathumtet, J., Boonmars, T., & Aukkanimart, R. (2022) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-022-00339-6 · Cited by 4

Nanoencapsulation: A New Way of Using Herbs and Spices in Food and Its Related Products

Muhammad, D. R. A. (2022) · Reviews in Agricultural Science · doi:10.7831/ras.10.0_288 · Cited by 4

Towards non-target proactive food safety: identification of active compounds in convenience tomato products by ten-dimensional hyphenation with integrated simulated gastrointestinal digestion

Schreiner, T., Eggerstorfer, N. M., & Morlock, G. E. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04656-0 · Cited by 4

Greenness Evaluation and Simultaneous High-Performance Thin-Layer Chromatography Method for Determination of Powder Mixture and Ayurvedic Formulation

Balekundri, A., Hurkadale, P. J., & Hegde, H. V. (2023) · National Academy Science Letters · doi:10.1007/s40009-023-01342-8 · Cited by 4

Prediction of bioactive compounds hepatotoxicity using in silico and in vitro analysis

Choi, K., Lee, S. Y., Yoo, S., Han, H., Park, S.-Y., & Kim, J. Y. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00961-z · Cited by 3

Study on the pharmacokinetics and brain tissue distribution of eight anti-inflammatory active components in normal and neuroinflammatory rats orally administered with extract of Tinospora sinensis (Lour.) Merr. using the UPLC-MS/MS method

Chen, L., Lu, L., Xu, G., Jiang, Z., Guo, Q., Huang, F., Yan, W., Zhang, H., Wu, Y., Xie, Y., et al. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106564 · Cited by 3

Pathogenesis of osteoarthritis and treatment with traditional Chinese medicine: New perspectives on platelet aggregation

Shao, Q., Zhang, S., & Li, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115665 · Cited by 3

GC–MS spectroscopic analysis of antimicrobial and antioxidant properties of bangladeshi spice piper chaba H. stems: a potential natural preservative for food

Shandhi, S. P., Sikdar, K., Ahmed, S., Khatun, M. M., & Nahar, A. (2025) · Food Chemistry Advances · doi:10.1016/j.focha.2025.101127 · Cited by 3

Anticancer effect of piperine, a black pepper compound, regulating apoptosis mediated through extracellular vesicles and cathepsin D in acute leukemia

Charoensedtasin, K., Kheansaard, W., Roytrakul, S., & Tanyong, D. I. (2025) · Scientific Reports · doi:10.1038/s41598-025-32898-8 · Cited by 3

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Xu, Y., Wu, K., Wei, B., Song, G., Sun, C., Li, X., Liu, X., Ma, Z., Lv, M., Landman, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202522455 · Cited by 3

Piperine reverses colistin resistance in multidrug resistant Gram-negative pathogens by membrane disruption and ROS damage

Zhang, J., Liu, Q., Shao, H., Feng, M., Li, Z., Feng, Y., Wu, H., He, D., Zhai, Y., & Hu, G. (2026) · Virulence · doi:10.1080/21505594.2026.2691333 · Cited by 3

Anti-aging strategies, plant bioactives, and drug development: current insights

Sripanidkulchai, B., Suttajit, M., & Ratanavalachai, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90581-7.00013-x · Cited by 3

Phytochemical Analysis and Biological Activities of Curcumin

-, P. M., & Mishra, S. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i04.5842 · Cited by 3

Black pepper extract reduces tumour incidence via suppressing tumour - promoted cytokines / chemokines and modulating T cell subtype

Mad-adam, N., Dokduang, S., Taraporn, S., Rattanaburee, T., Saetang, J., Nualla‐ong, A., Sriwiriyajan, S., Kaewsrichan, J., Sukpondma, Y., Hiransai, P., et al. (2024) · Food and Agricultural Immunology · doi:10.1080/09540105.2024.2408282 · Cited by 3

Guineensine: Isolation, Synthesis, and Biological Activity

Matiadis, D., Kakouri, E., Kaparakou, E. H., & Tarantilis, P. Α. (2025) · Applied Sciences · doi:10.3390/app15031444 · Cited by 3

Enhancing Radiotherapy Tolerance With Papaya Seed‐Derived Nanoemulsions

Siddiqui, M. T., Ölçeroğlu, B., Gümüş, Z. P., Şenışık, A. M., & Barlas, F. B. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70145 · Cited by 3

Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study

Yao, X., Hu, J., Zhang, X., & Hu, J. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06796-2 · Cited by 3

Protective Effect of Piperine on Indomethacin‐Induced Intestinal Damage

Gervasoni, K. N., Iacia, M. V. M. D. S., Silva, K. D., Franco, L. G., Mendes, M. E. F., Neves, T. J. D. C., Sanches, W. S., Oliveira, L. B. D., Saito, E., Vieira, K. C. D. O., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70097 · Cited by 3

Piperine targets SOAT1 to inhibit the progression of esophageal squamous cell carcinoma via ferroptosis

Wei, C., Shi, M., Li, W., & Wei, C. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157332 · Cited by 3

Bioactive Compounds from Plants Used as Therapeutic Agents in Biomedical Applications – a Literature Review –

", Paltinean, G. A., Riga, S., Tomoaia-Cotişel, M., Mocanu, A., & Tomoaia-Cotişel, M. (2021) · Annals of the Academy of Romanian Scientists Series on Biological Sciences · doi:10.56082/annalsarscibio.2021.2.103 · Cited by 3

Subunit-specific inhibition of BK channels by piperine

Kshatri, A. S., Rivero-Pérez, B., & Giráldez, T. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.09.002 · Cited by 3

IDENTIFICATION OF PHYTOCHEMICALS IN CONVOLVULUS PLURICAULIS, MICHELIA CHAMPACA AND CHROMOLAENA ODORATA BY ORBITRAP HIGH RESOLUTION LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (O-HRLCMS) AND ITS PHARMACOLOGICAL SIGNIFICANCE

Dwivedi, J. (2023) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2023/12.10.1023 · Cited by 3

Interactions between nutrients and fruit secondary metabolites shape bat foraging behavior and protein absorption

Gelambi, M., Morales‐M., E., & Whitehead, S. R. (2024) · Ecosphere · doi:10.1002/ecs2.4843 · Cited by 3

Validation and Quantification of Key Markers in Ayush Kwath, an Ayurvedic Immunity Enhancer Polyherbal Formulation, Through High-Performance Thin-Layer Chromatography

Patel, N. R., Thummar, K. N., Chauhan, S. P., & Vadalia, J. M. (2025) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-025-00619-x · Cited by 3

Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation

Devi, V., Deswal, G., Grewal, A. S., Sharma, A., & Guarve, K. (2025) · Current Aging Science · doi:10.2174/0118746098363055250218040726 · Cited by 3

Microemulsion-based drug delivery system identifies pepper alkaloids as anti-obesity compounds

Meng, T.-K., Han, R., Ma, P., Chen, S., Qi, B., Wang, Z., Li, X., & Deng, H. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01521-x · Cited by 3

High-performance thin-layer chromatography method development and validation for quantification of piperine in different extracts of Piper longum L. and its antioxidant activity

Gupta, I., Adin, S. N., Aqil, M., Mujeeb, M., & Akhtar, M. (2023) · Journal of Planar Chromatography – Modern TLC · doi:10.1007/s00764-023-00237-0 · Cited by 3

Aspects of DNA interaction with the natural heterocyclic compounds

Kamalabadi, M., & Chehardoli, G. (2024) · International Journal of Biology and Chemistry · doi:10.26577/ijbch2024v17i1-a5 · Cited by 2

Targeting Lysozyme-Linked Amyloidosis through Piperine-Functionalized Gold Nanoparticles

Bhatia, A., Mishra, N., Prajapati, K. P., Srinivasan, V. R., Roy, S., Bonda, R., Mittal, S., Priyadharshini., M., Dash, S., Mahato, O. P., et al. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01841 · Cited by 2

Isolation of Piperine from White Pepper (Piper Nigrum L) with Soxhlation and Maceration Extraction Methods

Harimurti, S., Mayudanti, W., Lestari, I., Arsito, P., Widada, H., & Febriansah, R. (2025) · Journal of Physics Conference Series · doi:10.1088/1742-6596/2989/1/012027 · Cited by 2

Characteristics of the biological activities of the piperidine complex: an anticancer and antioxidant investigation

Sabancılar, İ., Aydemir, M., & Kaya, S. (2025) · Northwestern Medical Journal · doi:10.54307/nwmj.2025.142 · Cited by 2

Effect on food-related pathogens and chemical fingerprint of regional recipes of Baharat, a traditional Middle Eastern spice blend

Stasi, M. D., Kaboudari, A., Mancini, S., Vacchina, V., Leo, M. D., Braca, A., & Fratini, F. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106994 · Cited by 2

From chemical profiling to bioactivity: Integrating spectrum-effect relationship and activity validation to discover anti-inflammatory markers in Wuwei Qingzhuo Pill

Shi, T., Yang, W., Yin, L., Zhang, X., Wang, Y., Bao, L., Bu, R., Lu, J., Bai, T., Xue, P., et al. (2025) · Journal of Chromatography B · doi:10.1016/j.jchromb.2025.124876 · Cited by 2

Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice

Jing-bo, F., Qin, L., Ding, L., Zhang, L., Shao, M., Tong, X., & Xu, J. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70201 · Cited by 2

Capsicum annuum L. and Piper nigrum L. in Poultry Nutrition: Powders, Extracts, and Bioactive Compounds in Dietary Applications

Park, G. Y., & Kim, J. H. (2025) · Korean Journal of Poultry Science · doi:10.5536/kjps.2025.52.4.257 · Cited by 2

Dietary Interventions for Sleep Health: Multi‐Population and Mendelian Randomization Evidence on Sleep Outcomes and Disorders

Lin, M., Ge, S., Abuduxukuer, K., Chen, Y. D., Yang, S., Han, K., & Chen, M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71475 · Cited by 2

Targeting ferroptosis with culinary spices: a dietary strategy for neuroprotection via the Nrf2/GPX4 axis

Hong, W., Qing, Y., & Liu, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1779927 · Cited by 2

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Tang, Y., Luo, Z., Zhao, X., Zhang, Y., Sun, M., & Zhang, J. (2026) · Medicine Bulletin · doi:10.1002/mdb2.70024 · Cited by 2

Therapeutic potential and mechanisms of plant metabolites in endometritis: a comprehensive review

Guan, Q., Gao, H., & Pan, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1818049 · Cited by 2

Dietary herbal mixture powder as a natural growth promoter: effects on growth performance, carcass traits, blood biochemistry, Antioxidant gene expression, and gut microbial load in arbor acres broilers

Algothmi, K. M., & Alshaya, D. S. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107141 · Cited by 2

Can Plant-Derived Anti-Inflammatory Compounds “Replace” Indomethacin in NSAID Therapy? Advances in Drug Delivery Systems of Indomethacin and Off-Label Medical Applications

Georgieva, P., Peneva, P., & Gvozdeva, Y. (2026) · Applied Biosciences · doi:10.3390/applbiosci5030075 · Cited by 2

Binding of piperine to mycobacterial RNA polymerase improves the efficacy of rifampicin activity against Mycobacterium leprae and nontuberculous mycobacteria

Murase, L. S., Lima, D. D. S., de Souza, J. V. P., Palomo, C. T., Caleffi-Ferracioli, K. R., Scodro, R. B. D. L., Siqueira, V. L. D., Seixas, F. A. V., & Cardoso, R. F. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2135602 · Cited by 2

Molecular docking and dynamics simulation of piperine as a potential inhibitor of class C beta-lactamase

Mansoori, H., Mosawi, S. H., & Bayan, A. M. (2023) · ghalib quarterly journal · doi:10.58342/ajid/ghalibuni.v.1.i.1.6 · Cited by 2

Investigation of target genes and potential mechanisms related to compound Xiao-ai-fei honey ointment based on network pharmacology and bioinformatics analysis

Abudurousuli, K., Talihati, Z., Hailati, S., Han, M., Nuer, M., Khan, N., Maihemuti, N., Dilimulati, D., Nueraihemaiti, N., Simayi, J., et al. (2023) · Medicine · doi:10.1097/md.0000000000034629 · Cited by 2

Untargeted UHPLC-MS deferential screening method and targeted UHPLC-MS/MS quantitative method for the determination of amino acids in mouse brain tissue

Zhou, Y., Li, H., Luo, H., Lin, Z., & Luo, W. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.109808 · Cited by 2

Smart nanomaterials in food formulations and enhancing the bioavailability of nutrients/nutraceuticals

Srivastava, N. K., Srivastav, A. K., & Shanker, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99682-2.00012-8 · Cited by 2

Ethnopharmacological importance of commonly used folk medicinal plants among the Malayali tribal community in Jawadhu Hills, Tamil Nadu, India: A review

Raj, M. S. A., & Ayyanar, M. (2024) · Ethnobotany Research and Applications · doi:10.32859/era.27.12.1-41 · Cited by 2

The draft genome of Piper longum L.

Mathew, D., & Valsalan, R. (2024) · Crop Science · doi:10.1002/csc2.21313 · Cited by 2

Microwave-assisted extraction of Trang peppercorn (Piper nigrum Linn.) and its α-glucosidase inhibitory activity and immune-stimulation

Pothipongsa, A., Phuwapraisirisan, P., & Damsud, T. (2024) · Natural Resources for Human Health · doi:10.53365/nrfhh/191948 · Cited by 2

Plantas medicinales de la Amazonía ecuatoriana con actividad antibacteriana: una revisión sistemática

Verdezoto, C. S. (2023) · Revista Bases de la Ciencia · doi:10.33936/revbasdelaciencia.v8i3.6708 · Cited by 2

Novel Combination of Traditional Ayurvedic Herb Piper longum L. and Modern Stem Cell Therapy for the Reversal of Glucocorticoid‐Induced Osteoporosis

Sanap, A. P., Bhonde, R. R., Shekatkar, M., Kharat, A. H., Kheur, S. M., Undale, V., Dharkar, N. S., Tillu, G. S., & Joshi, K. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400698 · Cited by 2

Advances in the analysis and application of metabolites from tropical plants

Xiao, Y., Xia, W., Yang, Z., Zhou, J., & Jie, L. (2025) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2025.102728 · Cited by 2

Process optimization and characterization of ragi‐based probiotic camel milk drink for enhanced functionality

Mishra, A., Dhyani, P., Goyal, C., Kumari, S., Yadav, K., Kumar, A., & Saharan, B. S. (2025) · Food biomacromolecules. · doi:10.1002/fob2.70029 · Cited by 2

Physical Stability of Carvedilol in Solid Dispersions with Porous Silica

KOVAČIČ, B., Planinšek, O., & Vrečer, F. (2010) · Scientia Pharmaceutica · doi:10.3797/scipharm.cespt.8-pms30 · Cited by 2

Hyaluronic acid‐folic acid‐modified Fe3O4 magnetic nanocarriers for targeted delivery of piperine: Formation, characterization, and biological study

Zare, M., & Sarkati, M. N. (2023) · Applied Organometallic Chemistry · doi:10.1002/aoc.7093 · Cited by 2

Ethnopharmacological investigations on Pluchea odorata (L.) Cass.

Bauer (2009) · Scientia Pharmaceutica · doi:10.3797/scipharm.oephg.21.po-67 · Cited by 2

Nutraceuticals Productions from Plants

Rosa, I. S., Pires, L. O., & Ishida, J. K. (2023) · Wiley eBooks · doi:10.1002/9781119875116.ch15 · Cited by 1

Black pepper (Piper nigrum) oleoresin has a neuroprotective effect on apoptosis induced by activity deprivation

Saga, Y., Yamanishi, A., Matsumoto, M., Yoshioka, Y., Zaima, N., & Konishi, Y. (2023) · Food Science and Technology Research · doi:10.3136/fstr.fstr-d-23-00094 · Cited by 1

Eating and Healing: Traditional Food as Medicine

Bandekar, S. S., & Namdeo, A. G. (2023) · Springer eBooks · doi:10.1007/978-981-99-7703-1_24 · Cited by 1

Practical concepts to reveal metabolite group types in natural dietary based on 1H and 13C nuclear magnetic resonance spectra: a narrative review

Saifudin, A., Maryati, M., Bakar, M. F. A., Norimoto, H., Tezuka, Y., & Tanaka, K. (2025) · Food Research · doi:10.26656/fr.2017.9(1).194 · Cited by 1

308-nm excimer laser combined with piperine promotes melanin synthesis through PTEN/PDK1/GSK3b regulation of keratinocyte paracrine

Wu, Y., Wang, X., Liu, J., Wang, Z., Li, J., Zhang, W., Xiang, J., Li, R., Du, S., & Ao, C. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-025-04095-0 · Cited by 1

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Damanhouri, Z. A. (2014) · Medicinal & Aromatic Plants · doi:10.4172/2167-0412.1000161 · Cited by 257

Black Pepper (Piper nigrum L.): The King of Spices

Soni, P., Soni, V., & Choudhary, N. K. (2020) · Science of spices & herbs · doi:10.2174/9789811468360120030008 · Cited by 1

Therapeutic Role of Piper nigrum L (Black Pepper) and Pharmacological Activities

Saleem, A., Naureen, I., Naeem, M., Tasleem, G., Ahmed, H., & Farooq, U. (2022) · Scholars International Journal of Biochemistry · doi:10.36348/sijb.2022.v05i01.003 · Cited by 41

Therapeutic Potential of Piperine: A Review

Sarkar, S., Sarkar, S., Sanjib, G., Mistry, J., & Biswas, M. (2023) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2023.v09i02.020

Therapeutic Potential of Piperine: A Comprehensive Review

Singh, S. K., & Shukla, A. (2023) · The Natural Products Journal · doi:10.2174/0122103155273860230928071249 · Cited by 6