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Cited by 434Piperaceae Chemical and Biological StudiesBerberine and alkaloids researchMedicinal Plant Research

The DOI matches its Crossref record; 172 of the 176 references it cites were found in a registry or an index.

Piperine: A review of its biological effects

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Haq, Iahtisham‐Ul, Imran, Muhammad, Nadeem, Muhammad, Tufail, Tabussam, Gondal, Tanweer A., Mubarak, Mohammad S.·2021·Phytotherapy Research
DOI 10.1002/ptr.6855
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Abstract

Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases.Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice,P.nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

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Crossref · 10.1002/ptr.6855

Cites

172 of 172 references verified0 citation errors · 0 not checkable

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Cited works that were retracted

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Research works printed but not linked: 3

  1. Acharya S., 2012, Review of piperine as a bio‐enhancer, American Journal of PharmTech Research, 2, 32
  2. Alamgeer M. N. M., 2014, Evaluation of hypoglycemic activity of Thymus serpyllum Linn in glucose treated mice, International Journal of Basic Medical Sciences and Pharmacy (IJBMSP), 3, 33
  3. Joshi D. R., 2018, A review on diversified use of the king of spices: Piper nigrum (black pepper), International Journal of Pharmaceutical Sciences Research, 9, 4089

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Metadata

Authors
Haq, I., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S.
Affiliations
  • Department of Diet and Nutritional Sciences, Faculty of Health and Allied Sciences Imperial College of Business Studies Lahore Pakistan
  • University of Lahore (PK)
  • COMSATS University Islamabad (PK)
  • Deakin University (AU)
  • University of Jordan (JO)
Corresponding author
Mubarak, Mohammad S.
ORCID
Venue
Phytotherapy Research
Publisher
Wiley
Published
2020-09-14
Volume
35
Issue
2
Pages
680-700
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.6855
OpenAlex
W3085908711
Semantic Scholar
f1aefe8820681c8820b0346e3ff0fd578de1476d
Cited by
434
References
176
Citations by year
2026: 72 · 2025: 97 · 2024: 100 · 2023: 92 · 2022: 40 · 2021: 28 · 2020: 1
FWCI
5.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Piperaceae Chemical and Biological Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
piperine, black pepper, spices, medicinal plants, antiproliferative activity, anticancer activity, angiogenesis inhibition, antioxidant activity, antidiabetic effect, anti-obesity, cardioprotection, antimicrobial activity, anti-aging, immunomodulation, hepatoprotection, anti-allergic effects, anti-inflammatory activity, neuroprotection, disease prevention
MeSH terms
Alkaloids, Animals, Drug Therapy, Combination, Humans, Piperidines, Benzodioxoles, Polyunsaturated Alkamides

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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