Piperine: A review of its biological effects

Prevalence of Obesity Among Adults and Youth: United States, 2015-2016.

Hales, C. M., Carroll, M. D., Fryar, C. D., & Ogden, C. L. (2017) · PubMed · Cited by 3,884

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,656

Immunomodulatory and antitumor activity of Piper longum Linn. and piperine

Sunila, E. S., & Kuttan, G. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.10.016 · Cited by 539

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G., & Wicha, M. S. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0612-x · Cited by 503

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Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Majeed, M. A., & Sahebkar, A. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2014.12.019 · Cited by 407

Biological role of Piper nigrum L. (Black pepper): A review

Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60524-3 · Cited by 377

Piper nigrum and Piperine: An Update

Meghwal, M., & Goswami, T. K. (2013) · Phytotherapy Research · doi:10.1002/ptr.4972 · Cited by 366

Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

Elnaggar, Y. S. R., Etman, S. M., Abdelmonsif, D. A., & Abdallah, O. Y. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24557 · Cited by 327

Development of Statistically Optimized Piperine-Loaded Polymeric Nanoparticles for Breast Cancer: In Vitro Evaluation and Cell Culture Studies

Gilani, S. J., Bin-Jumah, M. N., & Fatima, F. (2023) · ACS Omega · doi:10.1021/acsomega.3c06605 · Cited by 18

Integrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang

Zhou, T., Xing, Q., Bu, J., Han, W., & Shen, Z. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-05066-9 · Cited by 18

Amorphous Polymer–Phospholipid Solid Dispersions for the Co-Delivery of Curcumin and Piperine Prepared via Hot-Melt Extrusion

Wdowiak, K., Miklaszewski, A., & Cielecka‐Piontek, J. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16080999 · Cited by 18

Nanoemulsion-based piperine to enhance bioavailability for the treatment of LPS-induced depression-like behaviour in mice

Basavaraju, S. M., Mudhol, S., Peddha, M. S., Wani, S. U. D., Krishna, K. L., Mehdi, S., & Kinattingal, N. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137441 · Cited by 18

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Chen, H., Zhang, G., Liu, M.-Q., Zhang, L., Kang, J., Wang, Z., Liu, W., Lin, A., & Kang, X. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9963677 · Cited by 18

Ethnopharmacology of medicinal plants used by the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia

Bhagawan, W. S., Ekasari, W., & Agil, M. (2023) · Biodiversitas Journal of Biological Diversity · doi:10.13057/biodiv/d241028 · Cited by 17

Effects of immersing treatment of curcumin and piperine combined with vacuum packaging on the quality of salmon (Salmo salar) during cold chain logistics

Qian, Y., Yu, J., Yu, Y.-J., Xie, J., & Yang, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1021280 · Cited by 17

Biofilm Formation and Phospholipase and Proteinase Production in Cryptococcus neoformans Clinical Isolates and Susceptibility towards Some Bioactive Natural Products

Bisso, B. N., Makuété, A. L., Tsopmene, U. J., & Dzoyem, J. P. (2023) · The Scientific World JOURNAL · doi:10.1155/2023/6080489 · Cited by 17

The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems

Yu, L., Zhang, X., Sun, W., Guang, S., Yang, Y., & Zeng, M. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136119 · Cited by 17

Amorphous System of Hesperetin and Piperine—Improvement of Apparent Solubility, Permeability, and Biological Activities

Wdowiak, K., Miklaszewski, A., Pietrzak, R., & Cielecka‐Piontek, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054859 · Cited by 16

Impact of Compressional Force, Croscarmellose Sodium, and Microcrystalline Cellulose on Black Pepper Extract Tablet Properties Based on Design of Experiments Approach

Monton, C., Wunnakup, T., Suksaeree, J., Charoenchai, L., & Chankana, N. (2023) · Scientia Pharmaceutica · doi:10.3390/scipharm91030030 · Cited by 16

The effect of allyl isothiocyanate addition on consumers' saltiness perception

Amyoony, J., Gorman, M., Dabas, T., Moss, R. H., & McSweeney, M. B. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16855 · Cited by 16

The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Hosseini, H., Ghavidel, F., Rajabian, A., Tabrizi, M. H., Majeed, M. A., & Sahebkar, A. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673260515240322074849 · Cited by 16

Metabolic landscaping of extracellular vesicles from body fluids by phosphatidylserine imprinted polymer enrichment and mass spectrometry analysis

Feng, L., Cheng, X., Qi, X., Li, D., & Hu, L. (2024) · Talanta · doi:10.1016/j.talanta.2024.126940 · Cited by 16

Dynamic comparative analysis of moisture and flavour characteristics in green peppers (Piper nigrum L.) during thermal and non-thermal drying processes

Wang, X., Huang, Y., Su, H. L., Lyu, Y., Chen, H., Chen, W., Zhong, Q., Zhang, M., Pei, J., He, R., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144926 · Cited by 16

Alpha-mangostin, piperine and beta-sitosterol as hepatitis C antivirus (HCV): In silico and in vitro studies

Saputro, A. H., Amelia, T., Mahardhika, A. B., Widyawaruyanti, A., Wahyuni, T. S., Permanasari, A. A., Artarini, A., Tjahjono, D. H., & Damayanti, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20141 · Cited by 16

Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships

Li, S., Lv, M., & Xu, H. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220726121012 · Cited by 15

Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology

Lwamba, C., Aboushanab, S. A., Ambati, R. R., & Kovaleva, E. G. (2023) · Sustainable Chemistry · doi:10.3390/suschem4010005 · Cited by 15

Alkaloids: Their relevance in cancer treatment

Varela, C. L., Silva, F., Costa, G., & Cabral, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99873-4.00006-2 · Cited by 15

Anti-leishmanial, immunomodulatory and additive potential effect of Piperine on Leishmania major: The in silico and in vitro study of Piperine and its combination

Sharifi, F., Mohamadi, N., Afgar, A., & Oliaee, R. T. (2023) · Experimental Parasitology · doi:10.1016/j.exppara.2023.108607 · Cited by 15

Hypolipidemic activity of phytochemical combinations: A mechanistic review of preclinical and clinical studies

Nechchadi, H., Nadir, Y., Benhssaine, K., Alem, C., Sellam, K., Boulbaroud, S., Berrougui, H., & Ramchoun, M. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140264 · Cited by 15

Natural products target programmed cell death signaling mechanisms to treat colorectal cancer

Zheng, Y., Feng, N., Li, C., & Li, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1565332 · Cited by 15

Comprehensive analysis of the impact of extraction methods on the volatile organic compounds and flavor profiles of Piper nigrum L. varieties

Zhang, J.-G., Wu, H., Ai, Z., Thakur, K., Hu, F., & Wei, Z. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145425 · Cited by 15

Plant biomolecule antimicrobials: an alternative control measures for food security and safety

Abdullahi, A., Tijjani, A., Abubakar, A. I., Khairulmazmi, A., & Ismail, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85852-6.00024-x · Cited by 15

Methanolic fraction of Cassia fistula L. bark exhibits potential to combat oxidative stress and possess antiproliferative activity

Kour, R., Sharma, N., Ahmad, S. S., Sharma, S., Nagaiah, K., Kumar, S., & Kaur, S. (2023) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2023.2189435 · Cited by 15

N-Cinnamoylpyrrole-derived alkaloids from the genus Piper as promising agents for ischemic stroke by targeting eEF1A1

Su, B.-J., Huang, G., Zhu, S., Wang, Y., Lan, Q., Hou, Y., & Liang, D. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155455 · Cited by 14

Metabolomic insights and bioactive efficacies of Tragopogon dubius root fractions: Antioxidant and antiproliferative assessments

Ahmad, S. S., Garg, C., Kour, R., Bhat, A. H., Raja, V., Gandhi, S. G., Ataya, F. S., Fouad, D., Radhakrishnan, A., & Kaur, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34746 · Cited by 14

Rationalizing the stability and noncovalent interactions of N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(methylthio)thiazole-4-carboxamide: Insights from X‐ray structure and QTAIM analysis

Lohith, T. N., K․, R. S., Santhosh, C., Sridhar, M. A., & M․P․, S. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.139407 · Cited by 14

Stability, bioavailability, and cellular antioxidant activity of piperine complexed with cyclic glucans

Cho, S., Jung, Y.-K., Rho, S., & Kim, Y. (2025) · Food Science and Biotechnology · doi:10.1007/s10068-025-01884-1 · Cited by 14

Curcumin/piperine modulates the butyrate levels and alleviates diabetic kidney disease via Nrf2/HO-1 signaling pathway

Zhu, Y., Sun, L., Guo, Z., Xin, P., Huang, F., Song, L., Man, Y., Ren, M., Ma, Z., & Wang, Y. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2538117 · Cited by 14

Integrating molecular docking and molecular dynamics simulation studies on the affinity and interactions of piperine with β-lactamase class A enzymes

Bayan, A. M., Mosawi, S. H., Fani, N., Behrad, M. S., Mehrpoor, A. J., Noori, M. Y., Shirzadi, R., Popalzai, A. S., & Amirkhezi, F. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.136151 · Cited by 14

The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study

kotb, R. R., Afifi, A. M., El-Houseini, M. E., Ezz-Elarab, M., Basalious, E. B., Omran, M. M., & Abdellateif, M. S. (2023) · Discover Oncology · doi:10.1007/s12672-023-00785-1 · Cited by 14

Impact of dietary piperine on growth performance, immune response, antioxidant status, and immune-related gene expression in pathogen-aggravated Cyprinus carpio

Giri, S. S., Kim, S. G., Saha, S., Kim, H. J., Jun, J. W., Chi, C., Sukumaran, V., & Park, S. C. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109081 · Cited by 14

Formulation and evaluation of dissolving microneedle for transdermal delivery of piperine: the effect of polymers concentration

Aisyah, A. N., Permana, A. D., Wahyudin, E., Elim, D., Mudjahid, M., Ikbal, I., Datu, N. N. P., & Aswad, M. (2024) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2024.2320948 · Cited by 14

Discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an in-silico approach

Elekofehinti, O. O., Adetoyi, I. R., Popoola, H. O., Ayodeji, F. O., Taiwo, F. A., Akinjiyan, M. O., Koledoye, O. F., Iwaloye, O., & Adegboyega, A. E. (2024) · In Silico Pharmacology · doi:10.1007/s40203-024-00197-1 · Cited by 14

Piperine-Loaded Zein Electrospun Nanofibers: Development, Characterization and Antibacterial Application

Daneshmand, S., Shahraki, O., Hosseynipour, H., Roshan, F., & Miri, M. A. (2023) · BioNanoScience · doi:10.1007/s12668-023-01246-3 · Cited by 13

Piperine Attenuates Bmal1-Mediated Glucose Metabolism Disorder in a Trpv1-Dependent Manner in HepG2 Cells

Sun, J., Tang, B., Ho, C., & Lu, M. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06683 · Cited by 13

The Search for Drugs Derived from Natural Products for Toxoplasma gondii Infection Treatment in the Last 20 Years - A Systematic Review

Marques-Santos, F., Faria, R. X., & Amendoeira, M. R. R. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266299409240606062235 · Cited by 13

Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells

Erfen, Ş., & Akbay, E. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00600-9 · Cited by 13

Plausibility of natural immunomodulators in the treatment of COVID-19–A comprehensive analysis and future recommendations

Akter, R., Rahman, M. R., Ahmed, Z. S., & Afrose, A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17478 · Cited by 13

Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery

Wang, X., Wang, J., & Li, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127019 · Cited by 13

The effect of red betel (Piper crocatum) water fraction as tyrosinase inhibitors: In vitro, molecular docking, and molecular dynamics studies

Safithri, M., Andrianto, D., Arda, A. G., Syaifie, P. H., Kaswati, N. M. N., Mardliyati, E., Ramadhan, D., Jauhar, M. M., Nugroho, D., Septaningsih, D. A., et al. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102933 · Cited by 13

An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer

Kostelecka, K., Bryliński, Ł., Komar, O., Michalczyk, J., Miłosz, A., Biłogras, J., Woliński, F., Forma, A., & Baj, J. (2024) · Cancers · doi:10.3390/cancers16081611 · Cited by 13

Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis

Zhong, M., Chen, L., Tao, Y., Zhao, J., Chang, B., Zhang, F., Tu, J., Cai, W., & Zhang, B. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106589 · Cited by 13

Antiinflammatory Activities of Curcumin and Spirulina: Focus on Their Role against COVID-19

Perna, A., Hay, E., Sellitto, C., Del Genio, E., De Falco, M., Guerra, G., De Luca, A., De Blasiis, P., & Lucariello, A. (2023) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2173354 · Cited by 12

Surface Functionalization of Piperine-Loaded Liposomes with Sophorolipids Improves Drug Loading and Stability

Chen, H., & Zhang, Q. (2022) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-022-09687-1 · Cited by 12

Antibacterial and Immunological Properties of Piperine Evidenced by Preclinical Studies: A Systematic Review

Murase, L. S., de Souza, J. V. P., Meneguello, J. E., Palomo, C. T., Milaré, Á. C. F. H. R., Negri, M., Siqueira, V. L. D., Demarchi, I. G., Teixeira, J. J. V., & Cardoso, R. F. (2023) · Future Microbiology · doi:10.2217/fmb-2023-0101 · Cited by 12

In situ forming gels as subcutaneous delivery systems of curcumin and piperine

Pula, W., Pepe, A., Ferrara, F., Bondi, A., Mariani, P., Ortore, M. G., Pecorelli, A., Ivarsson, J., Valacchi, G., & Esposito, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-87750-w · Cited by 12

Advancements in nasal drug delivery system of natural products

Hsu, Y., Yang, J., Cao, M., Xu, T., He, J., Hong, H., Jiang, L., Peng, S., & Xiong, P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1667517 · Cited by 12

Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis

Wali, A. F., Ali, S., Rashid, S., Alsaffar, R. M., Arafah, A. M., Qamar, W., Ahmad, A., Paray, B. A., Ahmad, S. B., Alsuwayni, B. M., et al. (2021) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2021.101629 · Cited by 12

Naru-3 inhibits inflammation, synovial hyperplasia, and neovascularization in collagen-induced arthritis in rats

Zhao, H., Duan, S., Shi, Y., Zhang, M., Zhang, L., Jin, Z., Fu, W., Xiao, W., Bai, T., Zhang, X., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116350 · Cited by 11

Targeting Cancer Hallmarks Using Selected Food Bioactive Compounds: Potentials for Preventive and Therapeutic Strategies

Talib, W. H., Abed, I., Raad, D., Alomari, R. K., Jamal, A., Jabbar, R., Alhasan, E. O., Alshaeri, H. K., Alasmari, M. M., & Law, D. S. N. (2024) · Foods · doi:10.3390/foods13172687 · Cited by 11

Structure optimization of natural product piperine to obtain novel and potent analogs with anti-inflammation pain and urate-lowering effect

Liu, C., Wang, W., Miao, R., Chen, H., Wang, N., Cheng, W., Zheng, F., Zheng, L. H., Pang, J., Qian, H., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117649 · Cited by 11

The potential role of Piper guineense (black pepper) in managing geriatric brain aging: a review

Ademuyiwa, O. H., Fasogbon, B. M., & Adebo, O. A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1980764 · Cited by 11

Harnessing piperine for enhanced antimicrobial activity of carbon dot-modified cellulose fibers

Ravindran, S., Khan, D., Khodja, A., Terro, T., Radha, R., Diab, R., Yalishev, V. S., & Al-Sayah, M. H. (2024) · Discover Applied Sciences · doi:10.1007/s42452-024-06187-4 · Cited by 11

Alkaloids as natural anti-allergy agents: A mini review

Javeed, A., Sarfraz, M., Bhutta, N. K., & Han, B. (2024) · Allergy medicine. · doi:10.1016/j.allmed.2024.100014 · Cited by 11

Dimeric Amide Alkaloid Enantiomers from Piper longum L. with Anti-Inflammatory and Antidiabetic Effects

Gou, G., Liu, L., Bao, W., Li, J., & Aisa, H. A. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c13133 · Cited by 10

Review on encapsulating bioactive compounds in spices

Babu, A., Shams, R., Dash, K. K., Bashir, O., Mukarram, S. A., & Kovács, B. (2025) · Food and Humanity · doi:10.1016/j.foohum.2025.100583 · Cited by 10

Molecules and targets of antidiabetic interest

Gawli, K., & Bojja, K. S. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100506 · Cited by 10

Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF-κB pathway

Kumar, D., Sarkar, A. R., Andrabi, N. I., Haq, S. A., Ahmed, M., Shukla, S. K., Ahmed, Z., & Rai, R. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156578 · Cited by 10

The Combined Impact of Curcumin: Piperine and Sorafenib on microRNAs and Different Pathways in Breast Cancer Cells

Effat, H., Houseini, M. E. E., & Abohashem, R. S. (2024) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-024-01212-0 · Cited by 10

Promoting remyelination in central nervous system diseases: Potentials and prospects of natural products and herbal medicine

Zhu, H., Hu, E., Guo, X. H., Yuan, Z., Jiang, H., Zhang, W., Tang, T., Wang, Y., & Li, T. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107533 · Cited by 10

Anti-proliferative Activity of Piper trioicum Leaf Essential Oil Based on Phytoconstituent Analysis, Molecular Docking and in silico ADMET Approaches

Panda, P. C., Jena, S., Ray, A., Sahoo, A., Das, P. K., Kamila, P. K., Kar, S. K., & Nayak, S. (2021) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666211222113239 · Cited by 10

Study on the effect and mechanisms of piperine against cervical cancer based on network pharmacology and experimental validation

Cheng, H. W., Li, Y., Cheng, J., Zhang, Y., & Zhang, B. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2023.2217611 · Cited by 10

Effect of incorporating white pepper ( Piper nigrum L.) oleoresin on starch/alginate films

Vargas, O. L. T., Agredo, I. A. R., & Loaiza, Y. V. G. (2024) · RSC Advances · doi:10.1039/d4ra00821a · Cited by 9

Naringenin attenuates Mandarin fish ranavirus (MRV)-induced hyperinflammation through the inhibition of MAPK and NF-κB signaling pathways

Zhang, Z., Ma, Y., Gao, X., Hu, C., Hao, L., Lu, H., Li, Y., & Liu, Z. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110593 · Cited by 9

Piperine alleviates nonalcoholic steatohepatitis by inhibiting NF-κB-mediated hepatocyte pyroptosis

Ran, S., Song, L., Yang, H. S., Yu, J., Zhen, Y.-H., & Liu, Q. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301133 · Cited by 9

Piperine inhibits the proliferation of colorectal adenocarcinoma by regulating ARL3-mediated endoplasmic reticulum stress

Wu, C., Qian, Y., Jiang, J. H., Li, D., & Li, F. (2024) · Biomolecules and Biomedicine · doi:10.17305/bb.2024.10525 · Cited by 9

Piperine as a molecular bridge mediates a ternary coamorphous system of polyphenols with enhanced pharmaceutical properties

Ke, J., Yuan, J., Pang, Z., Huang, R., Miao, W., & Heng, W. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.125139 · Cited by 9

Piperine as a promising therapeutic agent for silicosis: Targeting the JAK2-STAT3 signaling pathway and alleviating inflammation and fibrosis

Cai, X., Bai, Y., Liang, C., Zhou, J., Liu, Y., Guo, J., Jing, Y., Fang, Y., Hu, X., Wu, J., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114458 · Cited by 9

Therapeutic potential of Indian medicinal plants against Leishmania donovani: a review

Pyne, N., Bhattacharya, I., & Paul, S. (2023) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-023-00153-1 · Cited by 9

Effect of white pepper addition on the sensory perception of sodium‐reduced soup with an emphasis on saltiness perception

Moss, R. H., LeBlanc, J., Ritchie, C., Gorman, M., Ettinger, L., & McSweeney, M. B. (2023) · Journal of Sensory Studies · doi:10.1111/joss.12874 · Cited by 9

Critical review and mechanistic insights into the health-protective and Immunomodulatory activity of Tiryāq (Theriac) from the purview of Unani medicine

Nikhat, S., & Fazil, M. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100021 · Cited by 9

Assessing the causal association between human blood metabolites and the risk of gout

Xie, Y., Li, Y., Zhang, J., Chen, Y., Ren, R., Xiao, L., & Chen, M. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14129 · Cited by 8

UHPLC-HRMS/MS Chemical Fingerprinting of the Bioactive Partition from Cultivated Piper aduncum L.

de Luna, A. V., Fagundes, T. D. S. F., Ramos, Y. J., de Araújo, M. H., Muzitano, M. F., Calixto, S. D., Simão, T. L. B. V., de Queiróz, G. A., Guimarães, E. F., Marques, A. M., et al. (2024) · Molecules · doi:10.3390/molecules29081690 · Cited by 8

Piperine and piperine-loaded albumin nanoparticles ameliorate adjuvant-induced arthritis and reduce IL-17 in rats

Gholijani, N., Azarpira, N., Abolmaali, S. S., Tanideh, N., Ravanrooy, M.-H., Taki, F., & Daryabor, G. (2024) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2024.104937 · Cited by 8

Piperine inhibits fungal growth and protects against pyroptosis in Aspergillus fumigatus keratitis by regulating the mTOR/HIF-1α pathway

Li, H., Yu, B., Lin, J., Wang, Q., Zhang, L., Liu, X., Li, C., Liu, Y., Li, C., & Zhao, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114286 · Cited by 8

Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism

Balkrishna, A., Paliwal, R., Maity, M., Varshney, Y., Sinha, S., & Varshney, A. (2024) · Clinical Phytoscience · doi:10.1186/s40816-024-00371-0 · Cited by 8

Piperine as a Potential Nutraceutical Agent for Managing Diabetes and Its Complications: A Literature Review

Wang, Y., Xu, S., Tang, L., Gong, J., Su, D., & Yang, H. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2023.k.0098 · Cited by 8

Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review

Joshi, S., Salahuddin, S., Mazumder, A., Kumar, R., Shabana, K., Tyagi, S., Rana, K., Ahsan, M. J., Yar, M. S., Arya, A., et al. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266256255231009075303 · Cited by 8

Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures

Annalora, A. J., Coburn, J. L., Jozić, A., Iversen, P. L., & Marcus, C. B. (2024) · Human Genomics · doi:10.1186/s40246-024-00694-6 · Cited by 7

A comprehensive review on the main alkamides in Piper nigrum and anti-inflammatory properties of piperine

Guo, R. C., Fang, Y., Li, J., Gao, H., Niu, Z., Lv, Y., You, L., Zhang, J., Wang, X., Wu, G., et al. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10127-4 · Cited by 7

Molecular docking, dynamics and pharmacokinetics of Curcuma longa phytochemicals: A promising avenue for Parkinson's therapy

Zafar, M. G., Abbas, M., Haider, W., Fatima, T., Sharif, S., Riaz, M., Mohammed, O. A., Iqbal, M., Iqbal, M., Nazir, A., et al. (2025) · Journal of the Indian Chemical Society · doi:10.1016/j.jics.2025.101790 · Cited by 7

Nanotechnology-Based Plant Antioxidants: A Current Literature Review on Bioavailability and Oxidative Stress

Kılınç, G. E., & Açar, Y. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00689-2 · Cited by 7

Pleiotropic regulatory mechanisms and targeted therapeutic prospects of Galectin-3 in aging-related diseases

Yuan, J., Dong, X., Gao, Y. L., & Nao, J. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00744 · Cited by 7

Exploring the Therapeutic Role of Natural Products in Allergic Rhinitis Based on Pathophysiology and Signaling Pathways

Dong, B., Xie, L., & Li, Y. (2025) · Journal of Asthma and Allergy · doi:10.2147/jaa.s550615 · Cited by 7

Curcumin–piperine liposomal hydrogel formulation for topical management of atopic dermatitis and associated skin inflammation: optimization, in vitro and in vivo studies

Mathure, D. M., Bhise, V., Salunke, M. R., Borse, G., Ranpise, H. A., & Awasthi, R. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02144-2 · Cited by 7

Therapeutic effect of some natural active compounds for breast cancer

Gökalp, F. (2022) · Medical Oncology · doi:10.1007/s12032-022-01704-0 · Cited by 7

Designing novel piperine-vanillin nano-crystals for bioavailability enhancement

Tomar, D., & Kumar, S. (2023) · Inorganic and Nano-Metal Chemistry · doi:10.1080/24701556.2023.2267541 · Cited by 7

Development of piperine nanoparticles stabilized by OSA modified starch through wet-media milling technique with enhanced anti-adipogenic effect in 3T3-L1 adipocytes

Tang, B., Sun, J., Xiao, J., Cao, Y., Huang, Q., Ho, C., Kou, X., & Lu, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132738 · Cited by 7

Piperine induces cellular stresses, apoptosis, and cytotoxicity via JNK signaling and has concentration-dependently additive or synergistic effects with sorafenib in hepatocellular carcinoma: an in-vitro study

Özgün, G. S., Özgün, E., Karabas, T., Gökmen, S. S., & Eskiocak, S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03725-0 · Cited by 7

Nose-to-Brain Targeting of Resveratrol Nanoformulations

Bavafa, A., Negah, S. S., & Forouzanfar, F. (2025) · Current Vascular Pharmacology · doi:10.2174/0115701611337079250115071933 · Cited by 7

Multi-targeted MS-based metabolomics fingerprinting of black and white pepper coupled with molecular networking in relation to their in vitro antioxidant and antidiabetic effects

Baky, M. H., Maamoun, A. A., Nicolescu, A., Mocan, A., & Farag, M. A. (2025) · RSC Advances · doi:10.1039/d5ra03714j · Cited by 7

Neuropharmacology Potential of the Hydroalcoholic Extract from the Leaves of Piper cernuum: Anxiolytic, Hypnotic, and Antidepressant‐Like Effects

Maia, M. A., Jurcevic, J. D., Malheiros, Â., Cazarin, C. A., Dalmagro, A. P., Santo, C. D. E., da Silva, L. M., & de Souza, M. M. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/1183809 · Cited by 7

Piperine, a black pepper compound, induces autophagy and cellular senescence mediated by NF-κB and IL-6 in acute leukemia

Charoensedtasin, K., Kheansaard, W., Roytrakul, S., & Tanyong, D. I. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04641-9 · Cited by 7

A novel piperine derivative HJJ_3_5 inhibits colorectal cancer progression by modulating EMT signaling pathways

Cheng, W., Liu, S., He, J., Li, H., Liu, X., Hu, Z., Wang, X., Wu, Z., Xu, G., Liu, W., et al. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151323 · Cited by 7

High-performance thin-layer chromatography-based quantification of therapeutic phytochemicals in the methanolic extract of Ayurvedic formulation Drakshavaleha

Sona, D., Baghel, G. S., Chandravanshi, L., Sahu, U., Chauhan, N. S., Kumar, A., & Gupta, P. K. (2022) · Journal of Planar Chromatography – Modern TLC · doi:10.1007/s00764-022-00173-5 · Cited by 7

Neuroprotective Role of Piperine-Encapsulated Casein Micelles in Mitigating Intracellular Dyshomeostasis in Alzheimer’s Disease Pathology

Mishra, J., Singh, C., & Bhatti, J. S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05297-3 · Cited by 6

Piperine improves ischemic brain injury by promoting the regulation of the AMPK/PGC-1α pathway by Apelin 13

Xi, S., Ma, J., Yan, J., Li, Y., Zhang, P., Chen, H., Yang, G., Fu, X., Liu, J., & Zhang, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1746901 · Cited by 6

Phytochemicals and cancer

Iyer, M., Pal, K., & Upadhye, V. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19143-5.00007-4 · Cited by 6

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Damanhouri, Z. A. (2014) · Medicinal & Aromatic Plants · doi:10.4172/2167-0412.1000161 · Cited by 257

Black Pepper (Piper nigrum L.): The King of Spices

Soni, P., Soni, V., & Choudhary, N. K. (2020) · Science of spices & herbs · doi:10.2174/9789811468360120030008 · Cited by 1

Therapeutic Role of Piper nigrum L (Black Pepper) and Pharmacological Activities

Saleem, A., Naureen, I., Naeem, M., Tasleem, G., Ahmed, H., & Farooq, U. (2022) · Scholars International Journal of Biochemistry · doi:10.36348/sijb.2022.v05i01.003 · Cited by 41

Therapeutic Potential of Piperine: A Review

Sarkar, S., Sarkar, S., Sanjib, G., Mistry, J., & Biswas, M. (2023) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2023.v09i02.020

Therapeutic Potential of Piperine: A Comprehensive Review

Singh, S. K., & Shukla, A. (2023) · The Natural Products Journal · doi:10.2174/0122103155273860230928071249 · Cited by 6