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Cited by 401

The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.

Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity

Hebner, Christy M., Laimins, Laimonis A.·2006·Reviews in Medical Virology
DOI 10.1002/rmv.488
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Abstract

Human papillomaviruses (HPVs) are small double‐stranded DNA viruses that infect the cutaneous and mucosal epithelium. Infection by specific HPV types has been linked to the development of cervical carcinoma. HPV infects epithelial cells that undergo terminal differentiation and so encode multiple mechanisms to override the normal regulation of differentiation to produce progeny virions. Two viral proteins, E6 and E7, alter cell cycle control and are the main arbitrators of HPV‐induced oncogenesis. Recent data suggest that E6 and E7 also play a major role in the inhibition of the host cell innate immune response to HPV. The E1 and E2 proteins, in combination with various cellular factors, mediate viral replication. In addition, E2 has been implicated in both viral and cellular transcriptional control. Despite decades of research, the function of other viral proteins still remains unclear. While prophylactic vaccines to block genital HPV infection will soon be available, the widespread nature of HPV infection requires greater understanding of both the HPV life cycle as well as the mechanisms underlying HPV‐induced carcinogenesis. Copyright © 2005 John Wiley & Sons, Ltd.

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Metadata

Authors
Hebner, C. M., & Laimins, L. A.
Venue
Reviews in Medical Virology
Publisher
Wiley
Published
2005-11-15
Volume
16
Issue
2
Pages
83-97
ISSN
  • 1052-9276 (ISSN-L)
  • 1099-1654
DOI
10.1002/rmv.488
OpenAlex
W2100448174
Cited by
401
References
161
FWCI
13.31
Type
journal article
Language
en
Open access
closed

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