Cited by 133Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsAdvanced Drug Delivery Systems

Biodegradable Microalgae-Based Carriers for Targeted Delivery and Imaging-Guided Therapy toward Lung Metastasis of Breast Cancer

Zhong, Danni, Zhang, Dongxiao, Xie, Tingting, Zhou, Min·2020·Small

Abstract

High delivery efficiency, prolonged drug release, and low systemic toxicity are effective weapons for drug delivery systems to win the battle against metastatic breast cancer. Herein, it is shown that Spirulina platensis (S. platensis) can be used as natural carriers to construct a drug-loaded system for targeted delivery and fluorescence imaging-guided chemotherapy on lung metastasis of breast cancer. The chemotherapeutic doxorubicin (DOX) is loaded into S. platensis (SP) via only one facile step to fabricate the DOX-loaded SP (SP@DOX), which exhibits ultrahigh drug loading efficiency and PH-responsive drug sustained release. The rich chlorophyll endows SP@DOX excellent fluorescence imaging capability for noninvasive tracking and real-time monitoring in vivo. Moreover, the micrometer-sized and spiral-shaped SP carriers enable the as-prepared SP@DOX to passively target the lungs and result in a significantly enhanced therapeutic efficacy on lung metastasis of 4T1 breast cancer. Finally, the undelivered carriers can be biodegraded through renal clearance without notable toxicity. The SP@DOX described here presents a novel biohybrid strategy for targeted drug delivery and effective treatment on cancer metastasis.

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Crossref · 10.1002/smll.202000819

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  • S. platensis used as a natural carrier of doxorubicin (Sp-DOX) exhibited ultrahigh drug loading efficiency and sustained release, significantly enhancing therapeutic efficacy on lung metastasis of 4T1 breast cancer.

    “The Sp-DOX carriers exhibited ultrahigh drug loading efficiency and sustained release, resulting in a significantly enhanced therapeutic efficacy on the lung metastasis of 4T1 breast cancer.”

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Authors
Zhong, D., Zhang, D., Xie, T., & Zhou, M.
Affiliations
  • Second Affiliated Hospital of Zhejiang University (CN)
  • Zhejiang University (CN)
Corresponding author
Zhou, Min
Venue
Small
Publisher
Wiley
Published
2020-04-15
Volume
16
Issue
20
Pages
e2000819-e2000819
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
OpenAlex
W3017137279
Cited by
132
References
41
Citations by year
2026: 9 · 2025: 36 · 2024: 27 · 2023: 31 · 2022: 16 · 2021: 11 · 2020: 2
FWCI
3.90
Type
journal article
Language
en
Open access
closed
Locations
  • Small (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Basic Research Program of China (2018YFC0115701)
  • National Natural Science Foundation of China (81971667, 81671748)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
Spirulina platensis, breast cancer lung metastasis, doxorubicin, targeted drug delivery, chlorophyll fluorescence imaging, 4T1 cells, biodegradable carriers, renal clearance
MeSH terms
Breast Neoplasms, Doxorubicin, Drug Carriers, Female, Humans, Lung Neoplasms, Drug Delivery Systems, Cell Line, Tumor, Spirulina, Nanoparticles, Microalgae, Drug Liberation

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