The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective
Abstract
Scaffold-based bone tissue engineering aims to repair/regenerate bone defects. Such a treatment concept involves seeding autologous osteogenic cells throughout a biodegradable scaffold to create a scaffold-cell hybrid that may be called a tissue-engineered construct (TEC). A variety of materials and scaffolding fabrication techniques for bone tissue engineering have been investigated over the past two decades. This review aims to discuss the advances in bone engineering from a scaffold material point of view. In the first part the reader is introduced to the basic principles of bone engineering. The important properties of the biomaterials and the scaffold design in the making of tissue engineered bone constructs are discussed in detail, with special emphasis placed on the new material developments, namely composites made of synthetic polymers and calcium phosphates. Advantages and limitations of these materials are analysed along with various architectural parameters of scaffolds important for bone tissue engineering, e.g. porosity, pore size, interconnectivity and pore-wall microstructures.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tissue-engineered bone regeneration
Petite, H., Viateau, V., Bensaïd, W., Meunier, A., de Pollak, C., Bourguignon, M., Oudina, K., Sedel, L., & Guillemin, G. (2000) · Nature Biotechnology · doi:10.1038/79449 · Cited by 1,475
Injectable biodegradable materials for orthopedic tissue engineering
Temenoff, J. S., & Mikos, A. G. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00108-3 · Cited by 554
Hierarchically biomimetic bone scaffold materials: nano‐HA/collagen/PLA composite
Liao, S. S., Cui, F. Z., Zhang, W., & Feng, Q. L. (2004) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.20035 · Cited by 487 · cited 1×
“Composites made of collagen–PLA–hydroxyapatite are also being increasingly considered for use as scaffold materials for bone tissue engineering (Liao et al., 2004a, 2004b).”
Review: Bone tissue engineering: The role of interstitial fluid flow
Hillsley, M. V., & Frangos, J. A. (1994) · Biotechnology and Bioengineering · doi:10.1002/bit.260430706 · Cited by 270
Liao, S. S., & Cui, F. Z. (2004) · Tissue Engineering · doi:10.1089/107632704322791718 · Cited by 142
Cited by
The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033
Self-citationNormal Bone Anatomy and Physiology
Clarke, B. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04151206 · Cited by 2,192
Nanoscale hydroxyapatite particles for bone tissue engineering
Zhou, H., & Lee, J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.03.019 · Cited by 1,541
Organ printing: Tissue spheroids as building blocks
Mironov, V., Visconti, R. P., Kasyanov, V., Forgacs, G., Drake, C. J., & Markwald, R. R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.084 · Cited by 1,238
3D printing of bone tissue engineering scaffolds
Wang, C., Huang, W., Zhou, Y., He, L., He, Z., Chen, Z., He, X., Tian, S., Liao, J., Lu, B., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.01.004 · Cited by 661
Metadata
- Authors
- Hutmacher, D. W., Schantz, J. T., Lam, C. X. F., Tan, K. C., & Lim, T. C.
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2007
- Volume
- 1
- Issue
- 4
- Pages
- 245-260
- ISSN
- 1932-6254 (ISSN-L)
- 1932-7005
- OpenAlex
- W2084304606
- Cited by
- 1,007
- References
- 5
- FWCI
- 28.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
