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Cited by 661Bone Tissue Engineering Materials3D Printing in Biomedical ResearchAnatomy and Medical Technology

3D printing of bone tissue engineering scaffolds

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Wang, Chong, Huang, Wei, Zhou, Yu, He, Libing, He, Zhi, Chen, Ziling, He, Xiao, Tian, Shuo +4 more·2020·Bioactive Materials
DOI 10.1016/j.bioactmat.2020.01.004PMC PMC6962643
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Abstract

Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes. In scaffold-based bone tissue engineering, a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape, structural, physical, chemical and biological features for enhanced biological performance and for regenerating complex bone tissues. Three-dimensional (3D) printing can produce customized scaffolds that are highly desirable for bone tissue engineering. The enormous interest in 3D printing and 3D printed objects by the science, engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries, including biomedical engineering, over the past decade. It is now possible to create novel bone tissue engineering scaffolds with customized shape, architecture, favorable macro-micro structure, wettability, mechanical strength and cellular responses. This article provides a concise review of recent advances in the R & D of 3D printing of bone tissue engineering scaffolds. It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing.

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  • Extrusion-based 3D printing is a common strategy because of low cost, simple and eco-friendly fabrication, high availability of materials, and diverse raw material forms.

    “extrusion-based 3D printing is a common strategy because of low cost, simple and eco-friendly fabrication, high availability of materials (metals, ceramics, polymers, hydrogels and their composites) and diverse raw material to process (wires, pellets, and powders) [18][19][20]”

    From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [18]

    The section on polyester scaffolds at high temperature says FDM is often adopted because it is low-cost, simple and eco-friendly, and that it uses wires or pellets. The Composition section describes ceramics, hydrogels, polymers and composites as printing materials and mentions powders, but the paper does not establish that extrusion-based printing accommodates the full listed range, particularly metals and powders, or that material availability itself explains its use. (LLM, conf=0.84)

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Authors
Wang, C., Huang, W., Zhou, Y., He, L., He, Z., Chen, Z., He, X., Tian, S., Liao, J., Lu, B., Wei, Y., & Wang, M.
Affiliations
  • Dongguan University of Technology (CN)
  • Wuhan Union Hospital (CN)
  • Chinese Academy of Sciences (CN)
  • Tsinghua University (CN)
  • University of Hong Kong (HK)
Corresponding author
  • Wang, Chong
  • Wang, Min
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2020-03
Volume
5
Issue
1
Pages
82-91
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2020.01.004
PMC
PMC6962643
OpenAlex
W2737721978
Cited by
661
References
3
Citations by year
2026: 46 · 2025: 106 · 2024: 120 · 2023: 129 · 2022: 122 · 2021: 92 · 2020: 43 · 2017: 2 · 2016: 1
FWCI
8.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Dongguan University of Technology High-level Talents (Innovation Team) Research Project (KCYCXPT201603)
  • Youth Innovative Talent Project from the Department of Education of Guangdong Province, China (2016KQNCX168)
  • Natural Science Foundation of Guangdong Province, China (2018A0303130019)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Anatomy and Medical Technology
Keywords
3D printing, bone tissue engineering, scaffolds, scaffold architecture, wettability, mechanical strength, cellular response, bone regeneration, scaffold fabrication

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