Pre‐mRNA 3′‐end processing complex assembly and function
Open accessAbstract
The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or poly(A) tail). These reactions take place in the pre‐mRNA 3′ processing complex, a macromolecular machinery that consists of more than 20 proteins. A general framework for how the pre‐mRNA 3′ processing complex assembles and functions has emerged from extensive studies over the past several decades using biochemical, genetic, computational, and structural approaches. In this article, we review what we have learned about this important cellular machine and discuss the remaining questions and future challenges. WIREs RNA 2011 2 321–335 DOI: 10.1002/wrna.54 This article is categorized under: RNA Processing > 3' End Processing
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IPA1 shares many genetic interactions in common with genes encoding members of the CPF and CF IA protein complexes.
“IPA1 shares many genetic interactions in common with genes encoding members of the Cleavage/Polyadenylation factor (CPF) and Cleavage Factor IA (CF IA) protein complexes (Fig. 4B, C), which along with HRP1, are essential for mRNA 3′ end processing (19).”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [19]
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Cites
The Spliceosome: Design Principles of a Dynamic RNP Machine
Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665 · see citing works
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349 · see citing works
Zhao, J., Hyman, L. E., & Moore, C. L. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.405-445.1999 · Cited by 1,024 · see citing works
A large-scale analysis of mRNA polyadenylation of human and mouse genes
Tian, B. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki158 · Cited by 944 · see citing works
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
McCracken, S. A., Fong, N., Yankulov, K., Ballantyne, S. M., Pan, G., Greenblatt, J., Patterson, S. D., Wickens, M., & Bentley, D. L. (1997) · Nature · doi:10.1038/385357a0 · Cited by 925 · see citing works
Comprehensive proteomic analysis of the human spliceosome
Zhou, Z., Licklider, L. J., Gygi, S. P., & Reed, R. (2002) · Nature · doi:10.1038/nature01031 · Cited by 893 · see citing works
Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation
Moore, M. J., & Proudfoot, N. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.001 · Cited by 835 · see citing works
Mechanism and regulation of mRNA polyadenylation
Colgan, D. F., & Manley, J. L. (1997) · Genes & Development · doi:10.1101/gad.11.21.2755 · Cited by 784 · see citing works
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
Marzluff, W. F., Wagner, E. J., & Duronio, R. J. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2438 · Cited by 768 · see citing works
Nemeroff, M. E., Barabino, S. M. L., Li, Y., Keller, W., & Krug, R. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80099-4 · Cited by 623 · see citing works
Mangus, D. A., Evans, M. C., & Jacobson, A. (2003) · Genome biology · doi:10.1186/gb-2003-4-7-223 · Cited by 601 · see citing works
Ji, Z., Lee, J. Y., Pan, Z., Jiang, B., & Tian, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900028106 · Cited by 595 · see citing works
RNA polymerase II and the integration of nuclear eventsPreprint
Hirose, Y., & Manley, J. L. (2000) · Genes & Development · doi:10.1101/gad.14.12.1415 · Cited by 575 · see citing works
Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex
Shi, Y., Giammartino, D. C. D., Taylor, D. J., Sarkeshik, A., Rice, W. J., Yates, J. R., Frank, J., & Manley, J. L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.028 · Cited by 560 · see citing works
Self-citationThe yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II
Kim, M., Krogan, N. J., Vasiljeva, L., Rando, O. J., Nedea, E. C., Greenblatt, J., & Buratowski, S. (2004) · Nature · doi:10.1038/nature03041 · Cited by 557 · see citing works
West, S., Gromak, N., & Proudfoot, N. J. (2004) · Nature · doi:10.1038/nature03035 · Cited by 506 · see citing works
Sheets, M. D., Ogg, S. C., & Wickens, M. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.19.5799 · Cited by 504 · see citing works
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors
Bentley, D. L. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.04.006 · Cited by 489 · see citing works
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease
Mandel, C. R., Kaneko, S., Zhang, H., Gebauer, D., Vethantham, V., Manley, J. L., & Tong, L. (2006) · Nature · doi:10.1038/nature05363 · Cited by 458 · see citing works
Simpson, G. G., Dijkwel, P. P., Quesada, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00425-2 · Cited by 447 · see citing works
Flavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works
Takagaki, Y., Seipelt-Thiemann, R. L., Peterson, M. L., & Manley, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)82000-0 · Cited by 425 · see citing works
Protein factors in pre-mRNA 3′-end processing
Mandel, C. R., Bai, Y., & Tong, L. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7474-3 · Cited by 415 · see citing works
Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation
Millevoi, S., & Vagner, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1176 · Cited by 393 · see citing works
RNA polymerase II is an essential mRNA polyadenylation factor
Hirose, Y., & Manley, J. L. (1998) · Nature · doi:10.1038/25786 · Cited by 359 · see citing works
Buratowski, S. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb0903-679 · Cited by 334 · see citing works
Structure and function of poly(A) binding proteins
Kühn, U., & Wahle, E. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.03.008 · Cited by 321 · see citing works
In vitro polyadenylation is stimulated by the presence of an upstream intron.Preprint
Niwa, M., Rose, S. D., & Berget, S. M. (1990) · Genes & Development · doi:10.1101/gad.4.9.1552 · Cited by 314 · see citing works
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
Callebaut, I. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf470 · Cited by 311 · see citing works
Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA
Dantonel, J.-C., Murthy, K. G. K., Manley, J. L., et al. (1997) · Nature · doi:10.1038/38763 · Cited by 307 · see citing works
Zhong, X.-Y., Wang, P., Han, J., Rosenfeld, M. G., & Fu, X. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.016 · Cited by 304 · see citing works
3′ end mRNA processing: molecular mechanisms and implications for health and disease
Danckwardt, S., Hentze, M. W., & Kulozik, A. E. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601932 · Cited by 296 · see citing works
New perspectives on connecting messenger RNA 3′ end formation to transcription
Proudfoot, N. J. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.03.007 · Cited by 285 · see citing works
Gunderson, S., Polycarpou‐Schwarz, M., & Mattaj, I. W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80026-x · Cited by 279 · see citing works
Ji, Z., & Tian, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008419 · Cited by 264 · see citing works
Human Fip1 is a subunit of CPSF that binds to U‐rich RNA elements and stimulates poly(A) polymerase
Kaufmann, I., Martin, G., Friedlein, A., Langen, H., & Keller, W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600070 · Cited by 257 · see citing works
Murthy, K. G. K., & Manley, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.21.2672 · Cited by 254 · see citing works
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs
Mellman, D. L., Gonzales, M. L., Song, C., Barlow, C. A., Wang, P., Kendziorski, C. M., & Anderson, R. A. (2008) · Nature · doi:10.1038/nature06666 · Cited by 249 · see citing works
HU, J., Lutz, C. S., Wilusz, J., & Tian, B. (2005) · RNA · doi:10.1261/rna.2107305 · Cited by 249 · see citing works
Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component
Takagaki, Y., & Manley, J. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1515-1525.2000 · Cited by 248 · see citing works
Paushkin, S. V., Patel, M., Furia, B., Peltz, S. W., & Trotta, C. R. (2004) · Cell · doi:10.1016/s0092-8674(04)00342-3 · Cited by 240 · see citing works
A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.Preprint
Takagaki, Y., Manley, J. L., MacDonald, C. C., Wilusz, J., & Shenk, T. E. (1990) · Genes & Development · doi:10.1101/gad.4.12a.2112 · Cited by 232 · see citing works
Assembly of a processive messenger RNA polyadenylation complex.
Bienroth, S., Keller, W. D., & Wahle, E. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05690.x · Cited by 230 · see citing works
A Mechanism for the Regulation of Pre-mRNA 3′ Processing by Human Cleavage Factor Im
Brown, K. M., & Gilmartin, G. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00453-2 · Cited by 226 · see citing works
Venkataraman, K., Brown, K. M., & Gilmartin, G. M. (2005) · Genes & Development · doi:10.1101/gad.1298605 · Cited by 223 · see citing works
The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression
Kleiman, F. E., & Manley, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00270-7 · Cited by 215 · see citing works
The human RNA kinase hClp1 is active on 3′ transfer RNA exons and short interfering RNAs
Weitzer, S., & Martı̂nez, J. (2007) · Nature · doi:10.1038/nature05777 · Cited by 212 · see citing works
The Polyadenylation Factor CPSF-73 Is Involved in Histone-Pre-mRNA Processing
Domiński, Z., Yang, X.-C., & Marzluff, W. F. (2005) · Cell · doi:10.1016/j.cell.2005.08.002 · Cited by 212 · see citing works
Gunderson, S., Beyer, K., Martin, G., Keller, W., Boelens, W. C., & Mattaj, I. W. (1994) · Cell · doi:10.1016/0092-8674(94)90116-3 · Cited by 212 · see citing works
Rüegsegger, U., Beyer, K., & Keller, W. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6107 · Cited by 210 · see citing works
RNA Recognition by the Human Polyadenylation Factor CstF
Takagaki, Y., & Manley, J. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3907 · Cited by 205 · see citing works
An interaction between U2AF 65 and CF Im links the splicing and 3′ end processing machineries
Millevoi, S., Loulergue, C., Dettwiler, S., Karaa, Z. S., Keller, W., Antoniou, M. N., & Vagner, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601331 · Cited by 203 · see citing works
Keller, W., Bienroth, S., Lang, K. M., & Christofori, G. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb05002.x · Cited by 202 · see citing works
Kyburz, A., Friedlein, A., Langen, H., & Keller, W. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.037 · Cited by 198 · see citing works
Cleavage site determinants min the mammalian polydenylation signal
Chen, F., MacDonald, C. C., & Wilusf, J. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.14.2614 · Cited by 189 · see citing works
Rüegsegger, U., Blank, D., & Keller, W. D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80025-8 · Cited by 183 · see citing works
Evidence that polyadenylation factor CPSF-73 is the mRNA 3′ processing endonuclease
Ryan, K., Calvo, O., & Manley, J. L. (2004) · RNA · doi:10.1261/rna.5214404 · Cited by 183 · see citing works
Kaneko, S., Rozenblatt–Rosen, O., Meyerson, M. M., & Manley, J. L. (2007) · Genes & Development · doi:10.1101/gad.1565207 · Cited by 181 · see citing works
Kolev, N. G., & STEITZ, J. A. (2005) · Genes & Development · doi:10.1101/gad.1371105 · Cited by 175 · see citing works
Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.
Murthy, K. G. K., & Manley, J. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42111-4 · Cited by 169 · see citing works
Barabino, S. M. L., Hübner, W., Jenny, A., Minvielle-Sébastia, L., & Keller, W. (1997) · Genes & Development · doi:10.1101/gad.11.13.1703 · Cited by 169 · see citing works
Bienroth, S., Wahle, E., Suter‐Crazzolara, C., & Keller, W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55058-4 · Cited by 168 · see citing works
Cell-cycle related regulation of poly(A) polymerase by phosphorylation
Colgan, D. F., Murthy, K. G. K., Prives, C. L., et al. (1996) · Nature · doi:10.1038/384282a0 · Cited by 164 · see citing works
Dettwiler, S., Aringhieri, C., Cardinale, S., Keller, W., & Barabino, S. M. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403927200 · Cited by 162 · see citing works
Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation
Castelo‐Branco, P., Furger, A., Wollerton, M., Smith, C. W. J., Moreira, A., & Proudfoot, N. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4174-4183.2004 · Cited by 162 · see citing works
Zarudnaya, M. I. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg241 · Cited by 162 · see citing works
Alternative Polyadenylation: A Twist on mRNA 3′ End Formation
Lutz, C. S. (2008) · ACS Chemical Biology · doi:10.1021/cb800138w · Cited by 160 · see citing works
Calvo, O., & Manley, J. L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00236-2 · Cited by 154 · see citing works
Yang, Q., Gilmartin, G. M., & Doublié, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000848107 · Cited by 154 · see citing works
Johnson, S. A., Cubberley, G., & Bentley, D. L. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.007 · Cited by 153 · see citing works
Efficient RNA Polyuridylation by Noncanonical Poly(A) Polymerases
Rissland, O. S., Mikulasova, A., & Norbury, C. J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02209-06 · Cited by 149 · see citing works
Kubo, T., Wada, T., Yamaguchi, Y., et al. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl794 · Cited by 143 · see citing works
Independent functions of yeast Pcf11p in pre‐mRNA 3′ end processing and in transcription termination
Sadowski, M., Dichtl, B., Hübner, W., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg200 · Cited by 139 · see citing works
Takagaki, Y., & Manley, J. L. (1994) · Nature · doi:10.1038/372471a0 · Cited by 139 · see citing works
Trippe, R., Guschina, E., Hoßbach, M., Urlaub, H., Lührmann, R., & Benecke, B. (2006) · RNA · doi:10.1261/rna.87706 · Cited by 139 · see citing works
Zhang, Z., Fu, J., & Gilmour, D. S. (2005) · Genes & Development · doi:10.1101/gad.1296305 · Cited by 138 · see citing works
Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination
Dichtl, B., Blank, D., Sadowski, M., Hübner, W., Weiser, S., & Keller, W. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf390 · Cited by 134 · see citing works
Sullivan, K. D., Steiniger, M., & Marzluff, W. F. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.024 · Cited by 130 · see citing works
Topalian, S. L., Kaneko, S., Gonzales, M. I., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5614-5623.2001 · Cited by 129 · see citing works
Moore, C. L., Chen, J., & Whoriskey, J. S. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03183.x · Cited by 113 · see citing works
Sadofsky, M. J., & Alwine, J. C. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1460 · Cited by 113 · see citing works
Wallace, A. M., Dass, B., Ravnik, S. E., Tonk, V. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., & MacDonald, C. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6763 · Cited by 113 · see citing works
Ohnacker, M., Barabino, S. M. L., Preker, P., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.1.37 · Cited by 110 · see citing works
Pauws, E. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.8.1690 · Cited by 109 · see citing works
Edwalds-Gilbert, G., & Milcarek, C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6420 · Cited by 95 · see citing works
A functional human Poly(A) site requires only a potent DSE and an A‐rich upstream sequence
Nunes, N. M., Li, W., Tian, B., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.42 · Cited by 91 · see citing works
Bai, Y., Aupérin, T. C., Chou, C., Chang, G., Manley, J. L., & Tong, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.034 · Cited by 88 · see citing works
Loss of polyadenylation protein τCstF-64 causes spermatogenic defects and male infertility
Dass, B., Tardif, S., Park, J. Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707589104 · Cited by 85 · see citing works
HSF1 Modulation of Hsp70 mRNA Polyadenylation via Interaction with Symplekin
Xing, H., Mayhew, C. N., Cullen, K. E., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311719200 · Cited by 74 · see citing works
Sadofsky, M. J., & Alwine, J. C. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1460-1468.1984 · Cited by 72 · see citing works
Studies of the 5′ Exonuclease and Endonuclease Activities of CPSF-73 in Histone Pre-mRNA Processing
Yang, X.-C., Sullivan, K. D., Marzluff, W. F., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00776-08 · Cited by 70 · see citing works
Qu, X., Lykke‐Andersen, S., Nasser, T., Saguez, C., Bertrand, É., Jensen, T. H., & Moore, C. L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00468-09 · Cited by 67 · see citing works
Sumoylation regulates multiple aspects of mammalian poly(A) polymerase functionPreprint
Vethantham, V., Rao, N., & Manley, J. L. (2008) · Genes & Development · doi:10.1101/gad.1628208 · Cited by 62 · see citing works
A Novel Nuclear Human Poly(A) Polymerase (PAP), PAPγ
Kyriakopoulou, C., Nordvarg, H., & Virtanen, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104599200 · Cited by 61 · see citing works
Sartini, B. L., Wang, H., Wang, W., et al. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.064774 · Cited by 61 · see citing works
Graveley, B. R., Fleming, E. S., & Gilmartin, G. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4942 · Cited by 59 · see citing works
Qu, X., Pérez‐Cañadillas, J. M., Agrawal, S., Baecke, J. D., Cheng, H.-L. M., Varani, G., & Moore, C. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609981200 · Cited by 58 · see citing works
Multiple Histone Deacetylases and the CREB-binding Protein Regulate Pre-mRNA 3′-End Processing
Shimazu, T., Horinouchi, S., & Yoshida, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609745200 · Cited by 58 · see citing works
HIV-1 mRNA 3′ End Processing Is Distinctively Regulated by eIF3f, CDK11, and Splice Factor 9G8
Valente, S. T., Gilmartin, G. M., Venkataraman, K., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.004 · Cited by 57 · see citing works
Sumoylation Modulates the Assembly and Activity of the Pre-mRNA 3′ Processing Complex
Vethantham, V., Rao, N., & Manley, J. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01186-07 · Cited by 57 · see citing works
Human RNA 5′-kinase (hClp1) can function as a tRNA splicing enzyme in vivo
Ramirez, A., Shuman, S., & Schwer, B. (2008) · RNA · doi:10.1261/rna.1142908 · Cited by 57 · see citing works
Regulation of Yeast mRNA 3′ End Processing by Phosphorylation
He, X., & Moore, C. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.016 · Cited by 55 · see citing works
Mammalian pre-mRNA 3′ End Processing Factor CF Im68 Functions in mRNA Export
Ruepp, M., Aringhieri, C., Vivarelli, S., Cardinale, S., Paro, S., Schümperli, D., & Barabino, S. M. L. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-05-0389 · Cited by 55 · see citing works
The structure of the CstF-77 homodimer provides insights into CstF assembly
Legrand, P., Pinaud, N., Minvielle-Sébastia, L., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm458 · Cited by 48 · see citing works
Drosophila Sex‐lethal protein mediates polyadenylation switching in the female germline
Gawande, B. N., Robida, M. D., Rahn, A., & Singh, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601022 · Cited by 48 · see citing works
Noble, C. G. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh664 · Cited by 43 · see citing works
Crystal structure of the 25 kDa subunit of human cleavage factor I m
Coseno, M., Martin, G., Berger, C. L., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn079 · Cited by 43 · see citing works
An intronless gene encoding a poly(A) polymerase is specifically expressed in testis1
Lee, Y. J., Lee, Y., & Chung, J. H. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02367-x · Cited by 38 · see citing works
Nucleophosmin is selectively deposited on mRNA during polyadenylation
Viswanathan, P., Moraes, K. C. M., Wilusz, C. J., et al. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1080 · Cited by 32 · see citing works
Functionally Significant Secondary Structure of the Simian Virus 40 Late Polyadenylation Signal
Hans, H. H., & Alwine, J. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2926-2932.2000 · Cited by 32 · see citing works
Hockert, J. A., Yeh, H.-J., & MacDonald, C. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061705 · Cited by 27 · see citing works
Regulation of poly(A) polymerase by 14‐3‐3ϵ
Kim, H., Lee, J. H., & Lee, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg486 · Cited by 26 · see citing works
Monarez, R. R., MacDonald, C. C., & Dass, B. (2007) · Biochemical Journal · doi:10.1042/bj20061097 · Cited by 22 · see citing works
Sittler, A., Gallinaro, H., & Jacob, M. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0240 · Cited by 14 · see citing works
An up-close look at the pre-mRNA 3’-end processing complex
Shi, Y., Chen, S. H., & Martinez-Santibañez, G. (2009) · RNA Biology · doi:10.4161/rna.6.5.9554 · Cited by 11 · see citing works
Self-citationPolyadenylation: alternative lifestyles of the A‐rich (and famous?)
Dickson, A., & Wilusz, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.67 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
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A global genetic interaction network maps a wiring diagram of cellular function
Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240 · see citing works
The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
Shi, Y., & Manley, J. L. (2015) · Genes & Development · doi:10.1101/gad.261974.115 · Cited by 249 · see citing works
Self-citation
- Authors
- Chan, S., Choi, E., & Shi, Y.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Shi, Yongsheng
- ORCID
- Shi, Yongsheng
- Venue
- WIREs RNA
- Publisher
- Wiley
- Published
- 2010-10-18
- Volume
- 2
- Issue
- 3
- Pages
- 321-335
- ISSN
- 1757-7004 (ISSN-L)
- 1757-7012
- PMC
- PMC3980678
- OpenAlex
- W1984594593
- Cited by
- 147
- References
- 117
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 12 · 2016: 9 · 2015: 5 · 2014: 20 · 2013: 14 · 2012: 11
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Wiley Interdisciplinary Reviews - RNA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM090056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- pre-mRNA 3' end processing, polyadenylation, endonucleolytic cleavage, poly(A) tail, cleavage and polyadenylation specificity factor, CPSF6, poly(A) polymerase, protein complex formation, mRNA biogenesis
- MeSH terms
- Animals, Humans, Models, Biological, Plants, Polynucleotide Adenylyltransferase, DNA-Directed RNA Polymerases, RNA Precursors, Saccharomyces cerevisiae, RNA-Binding Proteins, RNA 3' End Processing, Poly(A)-Binding Proteins, RNA 3' Polyadenylation Signals, mRNA Cleavage and Polyadenylation Factors, Macromolecular Substances, Protein Interaction Domains and Motifs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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