The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Oxygen homeostasis
Abstract
Metazoan life is dependent upon the utilization of O 2 for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia‐inducible factor 1 (HIF‐1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF‐1 activity is regulated and by which HIF‐1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Physiology > Organismal Responses to Environment
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Citations
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Self-citation
Metadata
- Authors
- Semenza, G. L.
- Venue
- WIREs Systems Biology and Medicine
- Publisher
- Wiley
- Published
- 2010-04-09
- Volume
- 2
- Issue
- 3
- Pages
- 336-361
- ISSN
- 1939-005X (ISSN-L)
- 1939-5094
- OpenAlex
- W4248004095
- Cited by
- 297
- References
- 69
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
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