Cited by 712Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesPomegranate: compositions and health benefits

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Lycopene: A Biologically Important Carotenoid for Humans?

Stahl, Wilhelm, Sies, Helmut·1996·Archives of Biochemistry and Biophysics

DOI 10.1006/abbi.1996.0525

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Abstract

Lycopene is a carotenoid present in human blood (approximately 0.5 micromol/liter plasma), and the tissue levels vary from 1 nmol/g wet wt in adipose tissue to up to 20 nmol/g wet wt in adrenals and testes. Its biological activities include antioxidant activity (singlet oxygen quenching and peroxyl radical scavenging), induction of cell-cell communication, and growth control, but no provitamin A activity. Epidemiological studies suggest protective effects of lycopene on some types of cancer, e.g., prostate cancer. In vitro and in vivo studies on growth of tumor cells support this conclusion. The major sources of lycopene for the human are tomatoes and tomato products, and bioavailability from different food items varies considerably. Lycopene oxidation products have recently been identified in human serum. Suggested health effects of lycopene require further investigation.

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“Carotenoids are plant pigments found in algae photosynthetic pigments and protein complexes [6].”
Background
Lycopene, resveratrol, vitamin C and FeSO4 increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications
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“7 Epidemiological studies show that diet rich in tomato nd the consumption of tomato-based 8 products, are related to a lower risk for some types of cancer (Giovannucci, 2005, 1999; 9 Stahl and Sies, 1996).”
BackgroundMethod
Effects of Oxygenated Carotenoid β-Cryptoxanthin on Morphological Differentiation and Apoptosis in Neuro2a Neuroblastoma Cells
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Biofortified Vegetables for Improved Postharvest Quality: Special Reference to High-Pigment Tomatoes
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Tomatoes
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“[24,25] The constitutive compounds of garlic can selectively inhibit tumor proliferation by several factors, for example, controlling DNA repair mechanisms, chromosomal stability, and cell cycle regulation.”
Background

Authors: Stahl, W., & Sies, H.
Affiliations: Heinrich Heine University Düsseldorf (DE)
Corresponding author: Sies, Helmut
ORCID: Stahl, Wilhelm
Sies, Helmut
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 1996-12
Volume: 336
Issue: 1
Pages: 1-9
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1006/abbi.1996.0525
OpenAlex: W1981682289
Cited by: 712
References: 0
Citations by year: 2026: 8 · 2025: 5 · 2024: 15 · 2023: 23 · 2022: 20 · 2021: 16 · 2020: 15 · 2019: 23 · 2018: 23 · 2017: 29 · 2016: 30 · 2015: 35 · 2014: 26 · 2013: 30 · 2012: 22
FWCI: 11.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: lycopene, carotenoids, antioxidant activity, singlet oxygen quenching, peroxyl radical scavenging, intercellular communication, growth regulation, chemoprevention, prostate cancer, tissue distribution, bioavailability, tomato, human serum
MeSH terms: Lycopene, Antioxidants, Carotenoids, Diet, Humans, Tissue Distribution, beta Carotene

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Lycopene: A Biologically Important Carotenoid for Humans?

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