Cited by 712Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesPomegranate: compositions and health benefits

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Lycopene: A Biologically Important Carotenoid for Humans?

Stahl, Wilhelm, Sies, Helmut·1996·Archives of Biochemistry and Biophysics

DOI 10.1006/abbi.1996.0525

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Abstract

Lycopene is a carotenoid present in human blood (approximately 0.5 micromol/liter plasma), and the tissue levels vary from 1 nmol/g wet wt in adipose tissue to up to 20 nmol/g wet wt in adrenals and testes. Its biological activities include antioxidant activity (singlet oxygen quenching and peroxyl radical scavenging), induction of cell-cell communication, and growth control, but no provitamin A activity. Epidemiological studies suggest protective effects of lycopene on some types of cancer, e.g., prostate cancer. In vitro and in vivo studies on growth of tumor cells support this conclusion. The major sources of lycopene for the human are tomatoes and tomato products, and bioavailability from different food items varies considerably. Lycopene oxidation products have recently been identified in human serum. Suggested health effects of lycopene require further investigation.

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“최근에는 라이코핀이 macular degeneration 을 감소시키는 역할을 하며, 특히 전립선암을 예방하는 효과 가 있다고 보고되기도 하였다(Stahl & Sies 1996, Gerster 1997).”
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Background
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Background
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Self-citation
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“Epidemiological studies showed the protective role of lycopene against different types of cancers like stomach and prostate cancer [9, 10].”
Background
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BackgroundInfluential
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Background
Yield and Yield Contributing Performance of 75 Tomato Germplasm in Bangladesh
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“This protective effect has been mainly attributed to the carotenoid constituents of the fruits, particularly lycopene and β-carotene which act as antioxidants in detoxifying free radicals [4] [8] [9] [10].”
Background
Inhibitory Effect of Tomato Juice on Rat Urinary Bladder Carcinogenesis After N-Butyl-N-(4-hydroxybutyl)Nitrosamine Initiation
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Lycopene: Metabolism and Functional Aspects
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Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals
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Selenium alone or in combination with lycopene modifies liver metabolizing enzymes against galactosamine – A time bound study
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Evaluation of moisturizing lip balm comprise of natural pigment from tomato
Azmin, S. N. H. M., Abidin, Z. F. Z., Sulaiman, N. S., Nor, M. S. M., & Abdullah, P. S. (2022) · AIP conference proceedings · doi:10.1063/5.0078490 · Cited by 2
Substituting Natural Honey for Cane Sugar (Sucrose) Retards Microbial Growth Independent of Water Activity During Storage of Tomato Jam
Kapira, K., Nkhata, S. G., Makolija, N., et al. (2023) · European Journal of Agriculture and Food Sciences · doi:10.24018/ejfood.2023.5.1.609 · Cited by 2
Factors Influencing The Stability Of Carotenoids In Oil-In-Water Emulsions
Boon, C. S. (2021) · Scholarworks (University of Massachusetts Amherst) · doi:10.7275/5648773 · Cited by 2
A methodical approach for non-destructive estimation of plant pigments by means of remission spectroscopy applied in fruit and vegetable analyses
Pflanz, M. (2014) · doi:10.18452/17074 · Cited by 2
“, 1989) and can act as free radical scavengers (Stahl and Sies, 1996; Gerster, 1997).”
Background
Non-invasive in-vivo Raman spectroscopic measurement of the dynamics of the antioxidant substance lycopene in the human skin after a dietary supplementation
Darvin, M. E., Gersonde, I. H., Albrecht, H., et al. (2007) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.740598 · Cited by 2
Diet and Gastric Cancer
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Produção, caracterização, estabilidade e aplicação de microcapsulas de licopeno
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Effect of high CO2 and ocean acidification on photosynthesis and response to oxidative stress in seagrasses
Costa, M. L. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 2
LYCOPENES AND RELATED COMPOUNDS
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Authors: Stahl, W., & Sies, H.
Affiliations: Heinrich Heine University Düsseldorf (DE)
Corresponding author: Sies, Helmut
ORCID: Stahl, Wilhelm
Sies, Helmut
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 1996-12
Volume: 336
Issue: 1
Pages: 1-9
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1006/abbi.1996.0525
OpenAlex: W1981682289
Cited by: 712
References: 0
Citations by year: 2026: 8 · 2025: 5 · 2024: 15 · 2023: 23 · 2022: 20 · 2021: 16 · 2020: 15 · 2019: 23 · 2018: 23 · 2017: 29 · 2016: 30 · 2015: 35 · 2014: 26 · 2013: 30 · 2012: 22
FWCI: 11.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: lycopene, carotenoids, antioxidant activity, singlet oxygen quenching, peroxyl radical scavenging, intercellular communication, growth regulation, chemoprevention, prostate cancer, tissue distribution, bioavailability, tomato, human serum
MeSH terms: Lycopene, Antioxidants, Carotenoids, Diet, Humans, Tissue Distribution, beta Carotene

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Lycopene: A Biologically Important Carotenoid for Humans?

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