Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase

Starks, C. M., Back, K., Chappell, J., & Noel, J. P. (1997) · Science · doi:10.1126/science.277.5333.1815 · Cited by 750

Terpenoid Metabolism

McGarvey, D. J., & Croteau, R. (1995) · The Plant Cell · doi:10.1105/tpc.7.7.1015 · Cited by 722

Averting a malaria disaster

White, N. J., Nosten, F. H., Looareesuwan, S., Watkins, W., Marsh, K., Snow, R. W., Kokwaro, G. O., Ouma, J. H., Hien, T., Molyneux, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07367-x · Cited by 551

Enzymic formation of sesquiterpenes

Cane, D. E. (1990) · Chemical Reviews · doi:10.1021/cr00105a002 · Cited by 463

Sesquiterpene Synthases from Grand Fir (Abies grandis)

Steele, C. L., Crock, J. E., Bohlmann, J., & Croteau, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2078 · Cited by 415

Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

van Agtmael, M. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01302-4 · Cited by 351

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266

Gene family for an elicitor-induced sesquiterpene cyclase in tobacco.

Facchini, P. J., & Chappell, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11088 · Cited by 248

Cloning, Expression, and Characterization of (+)-δ-Cadinene Synthase: A Catalyst for Cotton Phytoalexin Biosynthesis

Chen, X., Chen, Y., Heinstein, P. F., & Davisson, V. J. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.0038 · Cited by 212

Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible ( E )-α-bisabolene synthase from grand fir ( Abies grandis )

Bohlmann, J., Crock, J. E., Jetter, R., & Croteau, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6756 · Cited by 193

β-Cyclodextrins enhance artemisinin production in Artemisia annua suspension cell cultures

Durante, M., Caretto, S., Quarta, A., Paolis, A. D., Nisi, R., & Mita, G. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3232-4 · Cited by 51

The molecular basis of glandular trichome development and secondary metabolism in plants

Tian, N., Liu, F., Wang, P., Zhang, X., Li, X., & Wu, G. (2017) · Plant Gene · doi:10.1016/j.plgene.2017.05.010 · Cited by 51

Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles

Frey, M., Vahabi, K., Cankar, K., Lackus, N. D., Padilla-González, G. F., Ro, D., Rieseberg, L. H., Spring, O., & Tissier, A. F. (2024) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2024.2307240 · Cited by 49

Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of Artemisia annua

Czechowski, T., Larson, T. R., Catania, T. M., Harvey, D., Wei, C., Essome, M., Brown, G. D., & Graham, I. A. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00641 · Cited by 47

Medicinal Plant Biotechnology

Latha, D. J. N. L., Mishra, D. K. K., Rajput, D. D. S., & Arul, D. V. (2006) · Wiley eBooks · doi:10.1002/9783527619771 · Cited by 46

Computational Identification of Sweet Wormwood (Artemisia Annua) microRNA and Their mRNA Targets

Pani, A., Mahapatra, R. K., Behera, N., & Naik, P. K. (2011) · Genomics Proteomics & Bioinformatics · doi:10.1016/s1672-0229(11)60023-5 · Cited by 46

Expression of key genes affecting artemisinin content in five Artemisia species

Salehi, M., Karimzadeh, G., Naghavi, M. R., Naghdi Badi, H., & Rashidi Monfared, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31079-0 · Cited by 44

Trichome-Specific Expression of Amorpha-4,11-Diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L., as Reported by a Promoter-GUS Fusion

Wang, H., Olofsson, L., Lundgren, A., & Brodelius, P. E. (2011) · American Journal of Plant Sciences · doi:10.4236/ajps.2011.24073 · Cited by 44

Quantitative Transcript Profiling Reveals Down-Regulation of A Sterol Pathway Relevant Gene and Overexpression of Artemisinin Biogenetic Genes in Transgenic Artemisia annua Plants

Yang, R.-Y., Feng, L.-L., Yang, X.-Q., Yin, L.-L., Xu, X.-L., & Zeng, Q.-P. (2008) · Planta Medica · doi:10.1055/s-2008-1081333 · Cited by 41

Expression of artemisinin biosynthesis genes in eight Artemisia species at three developmental stages

Ranjbar, M., Naghavi, M. R., Alizadeh, H., & Soltanloo, H. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.07.077 · Cited by 40

Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering

Abdallah, I. I., van Merkerk, R., Klumpenaar, E., & Quax, W. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-28177-4 · Cited by 41

Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgenic Artemisia annua

Feng, L.-L., Yang, R.-Y., Yang, X.-Q., Zeng, X.-M., Lu, W.-J., & Zeng, Q.-P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.03.014 · Cited by 39

The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L.

Chen, Y., Shen, Q., Wang, Y., Wang, T., Wu, S., Zhang, L., Lu, X., Zhang, F., Jiang, W., Qiu, B., et al. (2013) · Plant Biotechnology Reports · doi:10.1007/s11816-012-0262-z · Cited by 38

Systems and synthetic biology for plant natural product pathway elucidation

Qin, K., Liu, F., Zhang, C., Deng, R., Fernie, A. R., & Zhang, Y. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115715 · Cited by 39

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Kalalagh, K. F., Kashkooli, A. B., Babaei, A., Rezaei, A., & van der Krol, A. R. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.780257 · Cited by 40

Functional expression and characterization of sesquiterpene synthases from Artemisia annua L. using transient expression system in Nicotiana benthamiana

Kanagarajan, S., Muthusamy, S., Gliszczyńska, A., Lundgren, A., & Brodelius, P. E. (2012) · Plant Cell Reports · doi:10.1007/s00299-012-1250-z · Cited by 37

Biotechnological approaches for artemisinin production in Artemisia

Kayani, W. K., Kiani, B. H., Dilshad, E., & Mirza, B. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2432-9 · Cited by 37

Natural products from plant cell cultures

McCoy, E., & O'Connor, S. E. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8117-2_9 · Cited by 37

Trichome Specific Expression: Promoters and Their Applications

Tissier, A. F. (2012) · InTech eBooks · doi:10.5772/32101 · Cited by 37

Biochemistry of Terpenoids: Monoterpenes, Sesquiterpenes and Diterpenes

Ashour, M. L., Wink, M., & Gershenzon, J. (2017) · Wiley eBooks · doi:10.1002/9781119312994.apr0427 · Cited by 39

Cloning of artemisinin biosynthetic cDNAs and novel ESTs and quantification of low temperature-induced gene overexpression

Zeng, Q.-P., Chang, Z., Yin, L., Yang, R., Zeng, X.-M., Huang, Y., Feng, L.-L., & Yang, X. (2008) · Science in China Series C Life Sciences · doi:10.1007/s11427-008-0032-x · Cited by 34

Plant-based engineering for production of high-valued natural products

Sirirungruang, S., Markel, K., & Shih, P. M. (2022) · Natural Product Reports · doi:10.1039/d2np00017b · Cited by 35

Improved conditions for production of recombinant plant sesquiterpene synthases in Escherichia coli

Picaud, S., Olsson, M. E., & Brodelius, P. E. (2007) · Protein Expression and Purification · doi:10.1016/j.pep.2006.06.025 · Cited by 33

Surrogate Splicing for Functional Analysis of Sesquiterpene Synthase Genes

Wu, S., Schoenbeck, M. A., Greenhagen, B. T., Takahashi, S., Lee, S., Coates, R. M., & Chappell, J. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.059386 · Cited by 32

Recent advances in the biosynthesis of isoprenoids in engineered Saccharomyces cerevisiae

Wang, Z., Zhang, R., Yang, Q., Zhang, J., Zhao, Y., Zheng, Y., & Yang, J. (2020) · Advances in applied microbiology · doi:10.1016/bs.aambs.2020.11.001 · Cited by 35

Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants

Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31

Amalgamation of Synthetic Biology and Chemistry for High-Throughput Nonconventional Synthesis of the Antimalarial Drug Artemisinin

Singh, D., McPhee, D. J., Paddon, C. J., Cherry, J. R., Maurya, G., Mahale, G., Patel, Y., Kumar, N., Singh, S. C., Sharma, B. A., et al. (2017) · Organic Process Research & Development · doi:10.1021/acs.oprd.6b00414 · Cited by 31

Trichoderma asperellum ACCC30536 inoculation improves soil nutrition and leaf artemisinin production in Artemisia annua

Zhai, T., Wang, Y., Liu, C., Liu, Z., Zhao, M., Chang, Y., & Zhang, R. (2019) · Acta Physiologiae Plantarum · doi:10.1007/s11738-019-2836-7 · Cited by 29

Plant sesquiterpene lactones

Agatha, O., Mutwil‐Anderwald, D., Tan, J. Y., & Mutwil, M. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0350 · Cited by 28

Current status of metabolic phytochemistry

Petersen, M. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.07.029 · Cited by 28

The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.

Nguyen, K. T., Towler, M. J., & Weathers, P. J. (2013) · Plant Cell Reports · doi:10.1007/s00299-012-1355-4 · Cited by 27

Investigation of Glandular Trichome Proteins in Artemisia annua L. Using Comparative Proteomics

Wu, T., Wang, Y., & Guo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041822 · Cited by 27

Overexpression of the gibberellin 20-oxidase gene from Torenia fournieri resulted in modified trichome formation and terpenoid metabolities of Artemisia annua L.

Inthima, P., Nakano, M., Otani, M., Niki, T., Nishijima, T., Koshioka, M., & Supaibulwatana, K. (2017) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1171-1 · Cited by 26

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Ikram, N. K. K., Kashkooli, A. B., Peramuna, A., van der Krol, A. R., Bouwmeester, H. J., & Simonsen, H. T. (2019) · Molecules · doi:10.3390/molecules24213822 · Cited by 26

Genetic engineering of artemisinin biosynthesis: prospects to improve its production

Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25

An updated review on distribution, biosynthesis and pharmacological effects of artemisinin: A wonder drug

Nabi, N., Singh, S. K., & Saffeullah, P. (2023) · Phytochemistry · doi:10.1016/j.phytochem.2023.113798 · Cited by 25

Studies on the Expression of Sesquiterpene Synthases Using Promoter-β-Glucuronidase Fusions in Transgenic Artemisia annua L

Wang, H., Han, J., Kanagarajan, S., Lundgren, A., & Brodelius, P. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080643 · Cited by 25

Identification and characterization of (+)-α-bisabolol and 7-epi-silphiperfol-5-ene synthases from Artemisia abrotanum

Muangphrom, P., Misaki, M., Suzuki, M., Shimomura, M., Suzuki, H., Seki, H., & Muranaka, T. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.05.010 · Cited by 24

Amorpha-4,11-diene synthase: a key enzyme in artemisinin biosynthesis and engineering

Huang, J. Q., & Fang, X. (2021) · aBIOTECH · doi:10.1007/s42994-021-00058-x · Cited by 24

Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin

Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 25

Functional Analysis of Amorpha-4,11-Diene Synthase (ADS) Homologs from Non-Artemisinin-ProducingArtemisiaSpecies: The Discovery of Novel Koidzumiol and (+)-α-Bisabolol Synthases

Muangphrom, P., Seki, H., Suzuki, M., Komori, A., Nishiwaki, M., Mikawa, R., Fukushima, E. O., & Muranaka, T. (2016) · Plant and Cell Physiology · doi:10.1093/pcp/pcw094 · Cited by 24

Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomes

Zhang, M., Li, M., An, Y., Liu, C., Zhao, Q., Zhang, D., Pan, B., & Tan, H. (2025) · Nature Communications · doi:10.1038/s41467-025-63770-y · Cited by 24

Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana

Luo, F., Ling, Y., Li, D., Tang, T., Liu, Y., Liu, Y., & Li, S. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.03.009 · Cited by 23

Cloning, E. coli Expression and Molecular Analysis of Amorpha‐4,11‐Diene Synthase from a High‐Yield Strain of Artemisia annua L.

Li, Z., Liu, Y., Liu, B., Wang, H., Ye, H., & Li, G. (2006) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2006.00381.x · Cited by 23

Isolation and characterization of AaZFP1, a C2H2 zinc finger protein that regulates the AaIPPI1 gene involved in artemisinin biosynthesis in Artemisia annua

Deng, Y., Li, L., Peng, Q., Feng, L., Yang, J., Zhan, R., & Ma, D. (2022) · Planta · doi:10.1007/s00425-022-03892-5 · Cited by 22

Heterologous Expression, Purification, and Biochemical Characterization of α-Humulene Synthase from Zingiber zerumbet Smith

Alemdar, S., Hartwig, S., Frister, T., König, J. C., Scheper, T. H., & Beutel, S. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1888-4 · Cited by 22

Arsenic, chromium and NaCl induced artemisinin biosynthesis in Artemisia annua L.: A valuable antimalarial plant

Paul, S., & Shakya, K. (2013) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2013.09.025 · Cited by 22

Identification of Putative Artemisia annua ABCG Transporter Unigenes Related to Artemisinin Yield Following Expression Analysis in Different Plant Tissues and in Response to Methyl Jasmonate and Abscisic Acid Treatments

Zhang, L., Lu, X., Shen, Q., Chen, Y., Wang, T., Zhang, F., Wu, S., Jiang, W., Liu, P., Zhang, L., et al. (2011) · Plant Molecular Biology Reporter · doi:10.1007/s11105-011-0400-8 · Cited by 22

Searching for Artemisinin Production Improvement in Plants and Microorganisms

Barbacka, K., & Baer‐Dubowska, W. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798376923 · Cited by 22

Characterization of a trichome-specific promoter of the aldehyde dehydrogenase 1 (ALDH1) gene in Artemisia annua

Liu, M., Shi, P., Fu, X., Brodelius, P. E., Shen, Q., Jiang, W., He, Q., & Tang, K. (2016) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-016-1015-4 · Cited by 22

The Structural Peculiarities of the Leaf Glandular Trichomes: A Review

Muravnik, L. E. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-11253-0_3-1 · Cited by 21

Microbial Production of Isoprenoids

Wong, J., Rios‐Solis, L., & Keasling, J. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-50436-0_219 · Cited by 21

Effiziente chemoenzymatische Synthese von Dihydroartemisinaldehyd

Demiray, M., Tang, X., Wirth, T., Faraldos, J. A., & Allemann, R. K. (2017) · Angewandte Chemie · doi:10.1002/ange.201609557 · Cited by 21

Eudesmane-type sesquiterpene diols directly synthesized by a sesquiterpene cyclase in Tripterygium wilfordii

Tong, Y., Su, P., Guan, H.-Y., Hu, T., Chen, J., Zhang, Y., Zhao, Y., Gao, L., Zhang, X., Huang, L., et al. (2018) · Biochemical Journal · doi:10.1042/bcj20180353 · Cited by 21

AaABCG40 Enhances Artemisinin Content and Modulates Drought Tolerance in Artemisia annua

Fu, X., Liu, H., Hassani, D., Peng, B., Yan, X., Wang, Y., Wang, C., Li, L., Pin, L., Pan, Q., et al. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00950 · Cited by 21

Localization of sesquiterpene lactone biosynthesis in cells of capitate glandular trichomes of Helianthus annuus (Asteraceae)

Amrehn, E., Aschenbrenner, A.-K., Heller, A., & Spring, O. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0823-4 · Cited by 20

Kinetic analysis of cytochrome P450 reductase fromArtemisia annuareveals accelerated rates of NADPH-dependent flavin reduction

Simtchouk, S., Eng, J. L., Meints, C. E., Makins, C., & Wolthers, K. R. (2013) · FEBS Journal · doi:10.1111/febs.12567 · Cited by 20

Quantification of Three Key Enzymes Involved in Artemisinin Biogenesis in Artemisia annua by Polyclonal Antisera-Based ELISA

Zeng, Q.-P., Zeng, X.-M., Yin, L., Yang, R., Feng, L.-L., & Yang, X. (2008) · Plant Molecular Biology Reporter · doi:10.1007/s11105-008-0056-1 · Cited by 19

Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase

Fang, X., Li, J., Huang, J., Xiao, Y., Zhang, P., & Chen, X. (2017) · Biochemical Journal · doi:10.1042/bcj20170060 · Cited by 19

Side Products of Recombinant Amorpha-4,11-diene Synthase and Their Effect on Microbial Artemisinin Production

Huang, J., Li, D., Tian, X., Lin, J., Yang, L., Xu, J.-J., & Fang, X. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07462 · Cited by 17

Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues

Abdallah, I. I., Czepnik, M., van Merkerk, R., & Quax, W. J. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00236 · Cited by 17

Effect of wounding on gene expression involved in artemisinin biosynthesis and artemisinin production in Artemisia annua

Liu, D., Zhang, L., Li, C., Yang, K., Wang, Y., Sun, X., & Tang, K. (2010) · Russian Journal of Plant Physiology · doi:10.1134/s102144371006018x · Cited by 17

Production of Pharmaceuticals by Plant Tissue Cultures

Muranaka, T., & Saito, K. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00065-4 · Cited by 17

Chemistry, biosynthesis and biological activity of artemisinin and related natural peroxides

Rydén, A.-M., & Kayser, O. (2007) · Topics in Heterocyclic Chemistry · doi:10.1007/7081_2007_085 · Cited by 16

Drug Discovery and Development via Synthetic Biology

Cobb, R. E., Luo, Y., Freestone, T. S., & Zhao, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394430-6.00010-8 · Cited by 16

The Structural Peculiarities of the Leaf Glandular Trichomes: A Review

Muravnik, L. E. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30185-9_3 · Cited by 16

Biosynthesis of Plant Natural Products and Characterization of Plant Biosynthetic Pathways in Recombinant Microorganisms

Marasco, E. K., & Schmidt‐Dannert, C. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6031-1_1 · Cited by 15

Chromatin Accessibility Is Associated with Artemisinin Biosynthesis Regulation in Artemisia annua

Zhou, L., Huang, Y., Wang, Q., & Guo, D. (2021) · Molecules · doi:10.3390/molecules26041194 · Cited by 15

Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) under stressed environments

Tripathi, A., Pandey, P., Tripathi, S. N., & Kalra, A. (2025) · Plant Stress · doi:10.1016/j.stress.2025.100757 · Cited by 14

Optimization of amorphadiene production in engineered yeast by response surface methodology

Baadhe, R. R., Mekala, N. K., Parcha, S. R., & Devi, Y. P. (2013) · 3 Biotech · doi:10.1007/s13205-013-0156-y · Cited by 14

MADS-box gene AaSEP4 promotes artemisinin biosynthesis in Artemisia annua

Chen, T.-T., Yao, X., Liu, H., Li, Y., Qin, W. D., Yan, X., Wang, X., Peng, B., Zhang, Y., Shao, J., et al. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.982317 · Cited by 13

Metabolic engineering of biosynthetic pathways leading to isoprenoids: Mono- and sesquiterpenes in plastids and cytosol

Akhila, A. (2007) · Journal of Plant Interactions · doi:10.1080/17429140701670953 · Cited by 14

Synergistic interaction of two bHLH transcription factors positively regulates artemisinin biosynthetic pathway in Artemisia annua L.

Mohammad, Hurrah, I. M., Kumar, A., & Abbas, N. (2023) · Physiologia Plantarum · doi:10.1111/ppl.13849 · Cited by 12

Microbial Production

穴澤, 秀., & 清水, 昌. (2014) · Springer eBooks · doi:10.1007/978-4-431-54607-8 · Cited by 12

Biosynthesis of Sesquiterpene Lactones in Plants and Metabolic Engineering for Their Biotechnological Production

Perassolo, M., Cardillo, A. B., Busto, V. D., Giulietti, A. M., & Talou, J. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-78274-4_4 · Cited by 13

Molecular Biology of Glandular Trichomes and Their Functions in Environmental Stresses

Kundan, M., Gani, U., Nautiyal, A. K., & Misra, P. (2019) · Energy, environment, and sustainability · doi:10.1007/978-981-15-0690-1_17 · Cited by 12

Exploring multi-trophic plant-herbivore interactions for new crop protection methods

Bouwmeester, H. J., Verstappen, F. W. A., Aharoni, A., Lücker, J., Jongsma, M. A., Kappers, I. F., Luckerhoff, L. L. P., & Dicke, M. (2003) · Socio-Environmental Systems Modeling · Cited by 12

The last gene involved in the MEP pathway of Artemisia annua: Cloning and characterization and functional identification

Peng, M., Chen, M., Chen, R., Lan, X., Hsieh, M., Liao, Z., & Sweet, C. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9001219 · Cited by 12

Plant Terpenoids

Keeling, C. I., & Bohlmann, J. (2012) · Wiley eBooks · doi:10.1002/9781118391815.ch5 · Cited by 12

Glandular trichomes: the factory of artemisinin biosynthesis

Zhao, Q., Li, M., Zhang, M., & Tan, H. (2024) · Medicinal Plant Biology · doi:10.48130/mpb-0024-0018 · Cited by 11

Studies on the expression of linalool synthase using a promoter-β-glucuronidase fusion in transgenic Artemisia annua

Wang, H., Kanagarajan, S., Han, J., Hao, M.-S., Yang, Y., Lundgren, A., & Brodelius, P. E. (2013) · Journal of Plant Physiology · doi:10.1016/j.jplph.2013.09.019 · Cited by 11

Biosynthesis of artemisinin – revisited

Srivastava, N., & Akhila, A. (2011) · Journal of Plant Interactions · doi:10.1080/17429145.2011.570869 · Cited by 11

Probing Enzymatic Structure and Function in the Dihydroxylating Sesquiterpene Synthase ZmEDS

Jin, L. Y., Wang, L., Liu, J., Shen, Q., Fu, J., Peters, R. J., & Wang, Q. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00395 · Cited by 11

Isolation, characterization and structural studies of amorpha – 4, 11-diene synthase (ADS3963) from Arte a L. misia annu

Alam, P., Kiran, U., Ahmad, M. M., Kamaluddin, K., Khan, M. A., & Abdin, S. J. M. Z. (2010) · Bioinformation · doi:10.6026/97320630004421 · Cited by 11

Expression and Localization of Amorpha-4,11-diene Synthase in Artemisia annua L.

Pu, G., Ma, D., Wang, H., Ye, H., & Liu, B. (2012) · Plant Molecular Biology Reporter · doi:10.1007/s11105-012-0472-0 · Cited by 11

AaWRKY6 contributes to artemisinin accumulation during growth in Artemisia annua

Wang, X., Sun, W., Fang, S., Dong, B., Li, J., Li, W., Li, W., & Chen, W. (2023) · Plant Science · doi:10.1016/j.plantsci.2023.111789 · Cited by 10

Microscopic characterization of five Artemisia crude herbs using light microscopy, scanning electron microscopy, and microscopic quantitative analysis

Liu, Z., Li, X., Zhao, Y., Jin, Y., Jun-hui, Z., Huang, L., Zha, L., & Yuan, Y. (2022) · Microscopy Research and Technique · doi:10.1002/jemt.24098 · Cited by 10

Promoter variations in DBR2-like affect artemisinin production in different chemotypes of Artemisia annua

Wang, X., Wu, L., Li, X., Gao, R., Yin, Q., Wang, M., Liu, Z., Leng, L., Su, Y., Wan, H., et al. (2023) · Horticulture Research · doi:10.1093/hr/uhad164 · Cited by 10

Molecular Cloning and Characterization of a Broad Substrate Terpenoid Oxidoreductase from Artemisia annua

Rydén, A., Ruyter-Spira, C. P., Litjens, R. H. M. G., Takahashi, S., Quax, W. J., Osada, H., Bouwmeester, H. J., & Kayser, O. (2010) · Plant and Cell Physiology · doi:10.1093/pcp/pcq073 · Cited by 10

Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

Demiray, M., Miller, D. J., & Allemann, R. K. (2019) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.15.215 · Cited by 10

Plant Secondary Metabolism Engineering: Methods, Strategies, Advances, and Omics

Zárate, R. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00068-x · Cited by 10

Metabolic engineering of the anthocyanin biosynthetic pathway in Artemisia annua and relation to the expression of the artemisinin biosynthetic pathway

Judd, R., Dong, Y., Sun, X., Zhu, Y., Li, M., & Xie, D. (2023) · Planta · doi:10.1007/s00425-023-04091-6 · Cited by 9

Functional characterisation of twelve terpene synthases from actinobacteria

Chhalodia, A. K., Xu, H., Tabekoueng, G. B., Gu, B., Taizoumbe, K. A., Lauterbach, L., & Dickschat, J. S. (2023) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.19.100 · Cited by 8

Cloning and analyzing of chalcone isomerase gene (AaCHI) from Artemisia annua

Ma, J., Fu, X., Zhang, T., Qian, H., & Zhao, J. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-018-01549-4 · Cited by 8

Exploring and Accessing Plant Natural Product Biosynthesis in Engineered Microbial Hosts

Marasco, E. K., & Schmidt‐Dannert, C. (2006) · Wiley eBooks · doi:10.1002/9783527619771.ch13 · Cited by 8

Metabolic regulation and engineering of artemisinin biosynthesis in A. annua

Tang, Y., Xiang, L., Zhang, F., Tang, K., & Liao, Z. (2023) · Medicinal Plant Biology · doi:10.48130/mpb-2023-0004 · Cited by 7

Microbial Production of Isoprenoids

Keasling, J. D. (2009) · Springer eBooks · doi:10.1007/978-3-540-77587-4_219 · Cited by 7

Yeast Synthetic Biology for Production of Artemisinin as an Antimalarial Drug

Kashkooli, A. B., Kalalagh, K. F., & Babaei, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-89680-5_6 · Cited by 7

A Chemometrics Approach to the Investigation of the Intraspecific Variability of the Volatile Oil of Eupatorium tremulum from Southern Brazil

de Souza, T. J. T., Bordignon, S. A. D. L., & Apel, M. A. (2017) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00313 · Cited by 7

Microbial Production of Isoprenoids

Wong, J., Rios‐Solis, L., & Keasling, J. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-31421-1_219-2 · Cited by 7

Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin

Wallaart, T. E., Bouwmeester, H. J., Hille, J., Poppinga, L., & Maijers, N. C. A. (2001) · Planta · doi:10.1007/s004250000428 · Cited by 242

Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis

Chang, Y.-J., Song, S.-H., Park, S.-H., & Kim, S.-U. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2061 · Cited by 154

Cloning, Expression, and Characterization of epi-Cedrol Synthase, a Sesquiterpene Cyclase from Artemisia annua L

Mercke, P., Crock, J., Croteau, R., & Brodelius, P. E. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1358 · Cited by 127

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266

Expression, purification and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L.

Picaud, S., Olofsson, L., Brodelius, M., & Brodelius, P. E. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.02.012 · Cited by 117