Kinetin Delays the Onset of Aging Characteristics in Human Fibroblasts
Abstract
Kinetin (Kn) is a synthetic cytokinin plant growth hormone having some senescence-retarding effects in plants. Its effects on animal cells have been, until now, best considered as growth inhibitory and anti-tumorigenic. However, we have observed that an addition of 40-200 microM Kn in the culture medium of human diploid fibroblasts can both delay the onset and decrease the extent of many of the ageing characteristics that appear during serial passaging of normal cells in culture. Age-related changes that are affected by Kn include morphological alterations, growth rates, cell size, cytoskeletal organisation, macromolecular synthesis and the intensity of autofluorescence due to the oxidative damage product lipofuscin. These anti-ageing effects of Kn are achieved without any increase in the cell culture lifespan in terms of maximum proliferative capacity in vitro.
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Kinetin has strong anti-ageing effects on human skin cells and fruitflies.
“Recently, its strong anti-ageing effects on human skin cells and fruitflies (Zaprionus paravittiger) were also reported [26,59,60].”
From The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water (2009) · cites this paper as [26]
Kinetin has strong anti-ageing effects on human skin.
“kinetin (free base and riboside), which has strong anti-ageing effects on human skin [84]”
From Coconut water uses, composition and properties: a review (2012) · cites this paper as [84]
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BackgroundRETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D’Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 729 · see citing works
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Rabe, J. H., Mamelak, A. J., McElgunn, P. J. S., Morison, W. L., & Sauder, D. N. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.010 · Cited by 610 · see citing works
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Chondrogianni, N., Kapeta, S., Chinou, İ., Vassilatou, K., Papassideri, I. S., & Gonos, E. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.001 · Cited by 220 · see citing works
Katsiki, M., Chondrogianni, N., Chinou, İ., Rivett, A. J., & Gonos, E. S. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0513 · Cited by 188 · see citing works
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Rescue of a human mRNA splicing defect by the plant cytokinin kinetin
Slaugenhaupt, S. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh046 · Cited by 153 · see citing works
Skin connective tissue and ageing
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Ge, L., Yong, J. W. H., Goh, N. K., Chia, L. S., Tan, S. N., & Ong, E. S. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.09.026 · Cited by 126 · see citing works
Zalabák, D., Pospíšilová, H., Šmehilová, M., Mrízová, K., Frébort, I., & Galuszka, P. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.12.003 · Cited by 116 · see citing works
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Barciszewski, J., Massino, F. J., & Clark, B. F. C. (2006) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2006.06.024 · Cited by 113 · see citing works
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Li, H., Hao, R., Wu, S.-S., Guo, P., Chen, C.-J., Pan, L.-P., & Ni, H. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.042 · Cited by 103 · see citing works
Rattan, S. I. S., Fernandes, R. A., Demirovic, D., Dymek, B., & Lima, C. F. (2008) · Dose-Response · doi:10.2203/dose-response.08-014.rattan · Cited by 102 · see citing works
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Self-citationGe, L., Yong, J. W. H., Tan, S. N., Yang, X. H., & Ong, E. S. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.07.031 · Cited by 90 · see citing works
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Self-citationBarciszewski, J., Rattan, S. I. S., Siboska, G. E., & Clark, B. F. C. (1999) · Plant Science · doi:10.1016/s0168-9452(99)00116-8 · Cited by 82 · see citing works
Self-citationEvidence for the presence of kinetin in DNA and cell extracts
Barciszewski, J., Siboska, G. E., Pedersen, B. O., Clark, B. F. C., & Rattan, S. I. S. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00884-8 · Cited by 83 · see citing works
Self-citationHsiao, G., Shen, M.-Y., Lin, K.-H., Chou, C.-Y., Tzu, N.-H., Lin, C.-H., Chou, D.-S., Chen, T.-F., & Sheu, J.-R. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01528-0 · Cited by 79 · see citing works
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Self-citationMinorsky, P. V. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.471 · Cited by 74 · see citing works
Chiu, P., Chan, C., Lin, H., & Chiu, H. (2007) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2007.00342.x · Cited by 72 · see citing works
Barciszewski, J., Siboska, G. E., Pedersen, B. O., Clark, B. F. C., & Rattan, S. I. S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01037-5 · Cited by 71 · see citing works
Self-citationHims, M. M., Ibrahim, E. C., Leyne, M., Mull, J., Liu, L., Lázaro, C., Shetty, R. S., Gill, S., Gusella, J. F., Reed, R., et al. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0137-2 · Cited by 69 · see citing works
Rattan, S. I. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09891.x · Cited by 67 · see citing works
Self-citationBowie, L. E., Maiuri, T., Alpaugh, M., Gabriel, M. A., Arbez, N., Galleguillos, D., Hung, C. L.-K., Patel, S., Xia, J., Hertz, N. T., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801772115 · Cited by 66 · see citing works
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Self-citationCabello, C. M., Bair, W. B., Ley, S., Lamore, S. D., Azimian, S., & Wondrak, G. T. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.12.002 · Cited by 61 · see citing works
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Levin, J., & Momin, S. B. (2010) · PubMed Central · Cited by 59 · see citing works
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Oshchepkov, M., Kalistratova, A. V., Savelieva, E. M., Romanov, G. A., Bystrova, N. A., & Кочетков, К. А. (2019) · Russian Chemical Reviews · doi:10.1070/rcr4921 · Cited by 56 · see citing works
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Barciszewski, J., Mielcarek, M., Stobiecki, M., Siboska, G. E., & Clark, B. F. C. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3928 · Cited by 56 · see citing works
Self-citationGe, L., Yong, J. W. H., Tan, S. N., Yang, X. H., & Ong, E. S. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.027 · Cited by 55 · see citing works
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Kwak, J. Y., Ham, H. J., Kim, C. M., & Hwang, E. S. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2253 · Cited by 54 · see citing works
Carrette, L. L. G., Gyssels, E., Laet, N. D., & Madder, A. (2015) · Chemical Communications · doi:10.1039/c5cc08766j · Cited by 53 · see citing works
Actinic Keratosis: The Key Event in the Evolution from Photoaged Skin to Squamous Cell Carcinoma
Oppel, T., & Körting, H. C. (2004) · Skin Pharmacology and Physiology · doi:10.1159/000076016 · Cited by 51 · see citing works
Anti-Aging Properties of Plant Stem Cell Extracts
Miastkowska, M. A., & Sikora, E. S. (2018) · Cosmetics · doi:10.3390/cosmetics5040055 · Cited by 52 · see citing works
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Rattan, S. I. S., & Clark, B. F. C. (2005) · IUBMB Life · doi:10.1080/15216540500092195 · Cited by 49 · see citing works
Self-citationCytokinins: Wide-Spread Signaling Hormones from Plants to Humans with High Medical Potential
Fathy, M., Eldin, S. S., Naseem, M., Dandekar, T., & Othman, E. M. (2022) · Nutrients · doi:10.3390/nu14071495 · Cited by 49 · see citing works
Ageing—A biological perspective
Rattan, S. I. S. (1995) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(95)00005-2 · Cited by 49 · see citing works
Self-citationThe Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells
Othman, E. M., Naseem, M., Awad, E., Dandekar, T., & Stopper, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168386 · Cited by 47 · see citing works
N 6 -Furfuryladenine (Kinetin) as a Potential Anti-Aging Molecule
Rattan, S. I. S. (2002) · Rejuvenation Research · doi:10.1089/109454502317629336 · Cited by 43 · see citing works
Self-citationBerge, U., Kristensen, P. K., & Rattan, S. I. S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.009 · Cited by 43 · see citing works
Self-citationLee, J. H., Chung, K. Y., Bang, D., & Lee, K. H. (2006) · PROTEOMICS · doi:10.1002/pmic.200500287 · Cited by 43 · see citing works
Hahn, H. J., Jung, H. J., Schrammek-Drusios, M. C., Lee, S. N., Kim, J., Kwon, S. B., An, I., An, S., & Ahn, K. J. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3447 · Cited by 42 · see citing works
The plant hormone kinetin in disease therapy and healthy aging
Kadlecová, A., Maková, B., Artal‐Sanz, M., Strnad, M., & Voller, J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100958 · Cited by 41 · see citing works
N9-substituted derivatives of kinetin: Effective anti-senescence agents
Mik, V., Plíhalová, L., Šmehilová, M., Zatloukal, M., Doležal, K., Nisler, J., Grúz, J., Galuszka, P., Strnad, M., & Spíchal, L. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.02.002 · Cited by 42 · see citing works
Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells
Griffaut, B., Bos, R., Maurizis, J., Madelmont, J., & Ledoigt, G. (2004) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2004.06.004 · Cited by 40 · see citing works
Principles and practice of hormetic treatment of aging and age-related diseases
Rattan, S. I. S. (2008) · Human & Experimental Toxicology · doi:10.1177/0960327107083409 · Cited by 39 · see citing works
Self-citationTopical kinetin 0.1% lotion for improving the signs and symptoms of rosacea
Wu, J. J., Weinstein, G. D., Kricorian, G., Kormeili, T., & McCullough, J. L. (2007) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2007.02513.x · Cited by 39 · see citing works
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Berge, U., Kristensen, P. K., & Rattan, S. I. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.045 · Cited by 39 · see citing works
Self-citationGe, L., Yong, J. W. H., Tan, S. N., Yang, X. H., & Ong, E. S. (2005) · Electrophoresis · doi:10.1002/elps.200410234 · Cited by 37 · see citing works
Barciszewski, J., Siboska, G. E., Pedersen, B. O., Clark, B. F. C., & Rattan, S. I. S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7315 · Cited by 37 · see citing works
Self-citationKikowska, M. A., Chmielewska, M., Włodarczyk, A., Studzińska-Sroka, E., Żuchowski, J., Stochmal, A., Kotwicka, M., & Thiem, B. (2018) · Molecules · doi:10.3390/molecules23113009 · Cited by 36 · see citing works
Holck, D. E. E., & Ng, J. D. (2003) · Current Opinion in Ophthalmology · doi:10.1097/00055735-200310000-00004 · Cited by 36 · see citing works
Svendsen, L., Rattan, S. I. S., & Clark, B. F. C. (1994) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(94)90009-4 · Cited by 36 · see citing works
Self-citationMatuoka, K., Chen, K. Y., & Takenawa, T. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000840 · Cited by 34 · see citing works
Kaur, R., & Rup, P. J. (2003) · International Journal of Tropical Insect Science · doi:10.1017/s1742758400020336 · Cited by 33 · see citing works
A peptide carrier for the delivery of elastin into fibroblast cells
Nasrollahi, S. A., Fouladdel, S., Taghibiglou, C., Azizi, E., & Farboud, E. S. (2012) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2011.05214.x · Cited by 32 · see citing works
Lappas, C. M. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.33 · Cited by 32 · see citing works
The truth about over-the-counter topical anti-aging products: A comprehensive review
HUANG, C., & Miller, T. (2007) · Aesthetic Surgery Journal · doi:10.1016/j.asj.2007.05.005 · Cited by 30 · see citing works
FORMULATION AND EVALUATION OF ANTIAGING PHYTOSOMAL GEL
Joshua, J. M., Anilkumar, A., Cu, V., Vasudevan, D. T., & Surendran, S. A. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i3.24257 · Cited by 30 · see citing works
Pereira, S. M., Ribeiro, R., & Logarinho, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040938 · Cited by 30 · see citing works
Kimura, T., & Doi, K. (2004) · Rejuvenation Research · doi:10.1089/154916804323105062 · Cited by 30 · see citing works
Wei, Y., Liu, D., Zheng, Y., Hao, C., Li, H., & Ouyang, W. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9811-0 · Cited by 29 · see citing works
Lee, Y., Yang, Y.-C., Huang, C., Kuo, T.-Y., Lin, J., Yang, D., & Huang, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038865 · Cited by 29 · see citing works
Naseem, M., Othman, E. M., Fathy, M., Iqbal, J., Howari, F. M., AlRemeithi, F. A., Kodandaraman, G., Stopper, H., Bencúrová, E., Vlachakis, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70253-1 · Cited by 28 · see citing works
Galuszka, P., Spíchal, L., Kopečný, D., Tarkowski, P., Frébortová, J., Šebela, M., & Frébort, I. (2008) · Studies in natural products chemistry · doi:10.1016/s1572-5995(08)80028-2 · Cited by 27 · see citing works
CBFA1 and Topoisomerase I mRNA Levels Decline During Cellular Aging of Human Trabecular Osteoblasts
Christiansen, M., Kveiborg, M., Kassem, M. S., Clark, B. F. C., & Rattan, S. I. S. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.4.b194 · Cited by 27 · see citing works
Self-citationHönig, M., Plíhalová, L., Spíchal, L., Grúz, J., Kadlecová, A., Voller, J., Svobodová, A. R., Vostálová, J., Jitka Ulrichová, A., Doležal, K., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.03.043 · Cited by 26 · see citing works
Rattan, S. I. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00018-8 · Cited by 25 · see citing works
Self-citationAging Skin: Causes, Treatments, and Prevention
Bermann, P. E. (2007) · Nursing Clinics of North America · doi:10.1016/j.cnur.2007.05.001 · Cited by 25 · see citing works
Lazim, M. I. M., & Badruzaman, N. A. (2015) · Journal of Food Processing & Technology · doi:10.4172/2157-7110.1000515 · Cited by 29 · see citing works
CE for cytokinin analyses: A review
Ge, L., Tan, S., Yong, J. W. H., & Tan, S. N. (2006) · ELECTROPHORESIS · doi:10.1002/elps.200600195 · Cited by 23 · see citing works
Hashem, E. Z., & Eslami, M. (2016) · Cell and Tissue Banking · doi:10.1007/s10561-016-9604-3 · Cited by 23 · see citing works
Wyszko, E., Barciszewska, M. Z., Markiewicz, M., Szymański, M., Markiewicz, W. T., Clark, B. F. C., & Barciszewski, J. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(02)00622-x · Cited by 23 · see citing works
Self-citationPlant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases
Voller, J., Maková, B., Kadlecová, A., González, G., & Strnad, M. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_14 · Cited by 23 · see citing works
Effect of Antioxidants on the Fibroblast Replicative Lifespan In Vitro
Sadowska‐Bartosz, I., & Bartosz, G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6423783 · Cited by 24 · see citing works
Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers
An, S., Cha, H. J., Ko, J.-M., Han, H., Kim, S., Kim, K., Lee, S. J., An, I., Kim, S.-W., Youn, H. J., et al. (2017) · Annals of Dermatology · doi:10.5021/ad.2017.29.1.6 · Cited by 22 · see citing works
Ge, L., Tan, S. N., Yong, J. W. H., Hua, L., & Ong, E. S. (2008) · Electrophoresis · doi:10.1002/elps.200700474 · Cited by 22 · see citing works
Hipkiss, A. R. (2001) · Biogerontology · doi:10.1023/a:1011599321168 · Cited by 22 · see citing works
Brizzolari, A., Marinello, C., Carini, M., Santaniello, E., & Biondi, P. A. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.12.047 · Cited by 21 · see citing works
Vı́cha, J., Demo, G., & Marek, R. (2012) · Inorganic Chemistry · doi:10.1021/ic201595e · Cited by 21 · see citing works
Hwang, E. S., Ok, J., & Song, S. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9652-x · Cited by 21 · see citing works
Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans
Kadlecová, A., Jirsa, T., Novák, O., Kammenga, J. E., Strnad, M., & Voller, J. (2017) · Biogerontology · doi:10.1007/s10522-017-9742-4 · Cited by 20 · see citing works
Section VII. Trends and perspectives
Gaudillière, B., & Berna, P. P. (2000) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(00)35031-x · Cited by 20 · see citing works
Halim, H. H., Pak Dek, M. S., Hamid, A. A., Saari, N., Mohd Lazim, M. I., Abas, F., Ngalim, A., Ismail, A., & Jaafar, A. H. (2023) · Food Bioscience · doi:10.1016/j.fbio.2022.102326 · Cited by 18 · see citing works
Modulatory and Toxicological Perspectives on the Effects of the Small Molecule Kinetin
Othman, E. M., Fathy, M., Bekhit, A. A., Abdel‐Razik, A. H., Jamal, A., Nazzal, Y., Shams, S., Dandekar, T., & Naseem, M. (2021) · Molecules · doi:10.3390/molecules26030670 · Cited by 18 · see citing works
Modelling the rheological behaviour of tender coconut (Cocos nucifera l) water and its concentrates.
Manjunatha, S. S., & Raju, P. S. (2013) · International Food Research Journal · Cited by 18 · see citing works
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Christiansen, M., Stevnsner, T., Bohr, V. A., Clark, B. F. C., & Rattan, S. I. S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4826 · Cited by 18 · see citing works
Self-citationLiu, Y., Zhang, Z., & Yang, X. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb.9000341 · Cited by 17 · see citing works
Rattan, S. I. S. (2014) · Journal of Aging Science · doi:10.4172/2329-8847.1000122 · Cited by 17 · see citing works
Self-citationComposition, Properties and Reactions of Coconut Water
Rethinam, P., & Krishnakumar, V. (2022) · Coconut Water · doi:10.1007/978-3-031-10713-9_4 · Cited by 9 · see citing works
- Authors
- Rattan, S. I. S., & Clark, B. F. C.
- Affiliations
- Aarhus University (DK)
- ORCID
- Rattan, S.I.S.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 201
- Issue
- 2
- Pages
- 665-672
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2013313332
- Cited by
- 177
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 3 · 2013: 5 · 2012: 8
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- kinetin, cytokinins, cellular senescence, human diploid fibroblasts, anti-aging effects, lipofuscin, oxidative damage, cell morphology, cytoskeletal organization, cell growth rate, cell size, proliferative capacity, plant growth regulators
- MeSH terms
- Adenine, Adult, Breast, Cell Cycle, Cell Division, Cells, Cultured, Female, Fibroblasts, Humans, Kinetin, Plant Growth Regulators, Skin, Skin Aging, S Phase, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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