Skeletal muscle aging and the mitochondrion

Physical Activity in the United States Measured by Accelerometer

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works

Decline in skeletal muscle mitochondrial function with aging in humans

Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works

Sarcopenia with limited mobility: an international consensus

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

Hirschey, M. D., Shimazu, T., Jing, E., Grueter, C. A., Collins, A. M., Aouizerat, B., Stančáková, A., Goetzman, E., Lam, M. M., Schwer, B., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.019 · Cited by 787 · see citing works

Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing

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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

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Effects of aging, sex, and physical training on cardiovascular responses to exercise.

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Age-related decline in chaperone-mediated autophagy

Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665 · see citing works

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656 · see citing works

Oxidative capacity and ageing in human muscle

Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651 · see citing works

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

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Mitochondrial fission and remodelling contributes to muscle atrophy

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Endurance Exercise as a Countermeasure for Aging

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Effect of age on <i>in vivo</i> rates of mitochondrial protein synthesis in human skeletal muscle

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Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle: Molecular responses during mitochondrial biogenesis

Perry, C. G. R., Lally, J., Holloway, G. P., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.199448 · Cited by 559 · see citing works

Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

Bota, D. A., & Davies, K. J. A. (2002) · Nature Cell Biology · doi:10.1038/ncb836 · Cited by 557 · see citing works

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

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Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520 · see citing works

Age and aerobic exercise training effects on whole body and muscle protein metabolism

Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., & Nair, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00366.2003 · Cited by 470 · cited 3× · see citing works

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

Jing, E., Emanuelli, B., Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M., & Kahn, C. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111308108 · Cited by 469 · see citing works

Untitled work

Nair (2005) · doi:10.1093/ajcn/81.5.953 · Cited by 469 · see citing works

Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women

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Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S., & Aiken, J. M. (2006) · The American Journal of Human Genetics · doi:10.1086/507132 · Cited by 442 · see citing works

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

Chabi, B., Ljubicic, V., Menzies, K. J., Huang, J. H., Saleem, A., & Hood, D. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00347.x · Cited by 437 · see citing works

Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans

Guillet, C., Prod'homme, M., Balage, M., Gachon, P., Giraudet, C., Morin, L., Grizard, J., & Boirie, Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-1341fje · Cited by 412 · see citing works

Effects of exercise on mitochondrial content and function in aging human skeletal muscle

Menshikova, E. V., Ritov, V. B., Fairfull, L., Ferrell, R. E., Kelley, D. E., & Goodpaster, B. H. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.6.534 · Cited by 398 · see citing works

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397 · see citing works

Protein tyrosine nitration—Functional alteration or just a biomarker?

Souza, J. M., Peluffo, G., & Radí, R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.010 · Cited by 394 · see citing works

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

WANAGAT, J., CAO, Z., PATHARE, P., & AIKEN, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0320com · Cited by 378 · see citing works

Effects of Aging on Mitochondrial DNA Copy Number and Cytochromec Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart

Barazzoni, R., Short, K. R., & Nair, K. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3343 · Cited by 367 · see citing works

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

Aquilano, K., Vigilanza, P., Baldelli, S., Pagliei, B., Rotilio, G., & Ciriolo, M. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070169 · Cited by 347 · see citing works

Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics

Liu, X., Weaver, D., Shirihai, O. S., & Hajnóczky, G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.255 · Cited by 344 · see citing works

Decline with age of the respiratory chain activity in human skeletal muscle

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Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.004 · Cited by 319 · see citing works

Decline in VO2max with aging in master athletes and sedentary men

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Muscle fibre type adaptation in the elderly human muscle

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The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

Wu, J., Ruas, J. L., Estall, J. L., Rasbach, K. A., Choi, J. H., Ye, L., Boström, P., Tyra, H. M., Crawford, R. W., Campbell, K. P., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.003 · Cited by 312 · see citing works

Influence of Age on the Hemodynamic Response to Exercise

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Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles

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Oxidative capacity of human muscle fiber types: effects of age and training status

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Caloric Restriction and Aging: Studies in Mice and Monkeys

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Altered proteasome structure, function, and oxidation in aged muscle.

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Chapter 20: Functional Assessment of Isolated Mitochondria In Vitro

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Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise

Balagopal, P., Coenen-Schimke, J. M., Ades, P. A., Adey, D., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e203 · Cited by 248 · see citing works

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

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Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers

Picard, M., Ritchie, D., Wright, K. J., Romestaing, C., Thomas, M. M., Rowan, S. L., Taivassalo, T., & Hepple, R. T. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00628.x · Cited by 238 · see citing works

PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle

Leick, L., Wojtaszewski, J. F. P., Johansen, S. T., Kiilerich, K., Comes, G., Hellsten, Y., Hidalgo, J., & Pilegaard, H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00666.2007 · Cited by 236 · see citing works

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress

Bota, D. A., Van Remmen, H., & Davies, K. J. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03638-4 · Cited by 233 · see citing works

Oxidative stress and the mitochondrial theory of aging in human skeletal muscle

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Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo

Amara, C. E., Shankland, E. G., Jubrias, S. A., Marcinek, D. J., Kushmerick, M. J., & Conley, K. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610131104 · Cited by 223 · see citing works

Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia

Bua, E. A., McKiernan, S. H., Wanagat, J., McKenzie, D., & Aiken, J. M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01102.2001 · Cited by 223 · see citing works

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

Brault, J. J., Jespersen, J. G., & Goldberg, A. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.113092 · Cited by 217 · see citing works

Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults

Safdar, A., Hamadeh, M. J., Kaczor, J. J., Raha, S., deBeer, J., & Tarnopolsky, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010778 · Cited by 217 · see citing works

Resistance Exercise Increases Muscle Protein Synthesis and Translation of Eukaryotic Initiation Factor 2Bϵ mRNA in a Mammalian Target of Rapamycin-dependent Manner

Kubica, N., Bolster, D. R., Farrell, P. A., Kimball, S. R., & Jefferson, L. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413732200 · Cited by 207 · see citing works

Mitochondrial protein quality control during biogenesis and aging

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Age-related changes in ATP-producing pathways in human skeletal muscle in vivo

Lanza, I. R., Befroy, D. E., & Kent‐Braun, J. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00566.2005 · Cited by 192 · see citing works

Skeletal muscle oxidative capacity in young and older women and men

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Skeletal muscle mass and the reduction ofV˙ o 2 max in trained older subjects

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Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise

Glynn, E. L., Fry, C. S., Drummond, M. J., Dreyer, H. C., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00077.2010 · Cited by 167 · see citing works

Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women

Raue, U., Slivka, D., Minchev, K., & Trappe, S. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91587.2008 · Cited by 166 · see citing works

Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility

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Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans

Tonkonogi, M., Fernström, M., Walsh, B., Ji, L. L., Rooyackers, O., Hammarqvist, F., Wernerman, J., & Sahlin, K. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1044-9 · Cited by 159 · see citing works

Age and sex influence on oxidative damage and functional status in human skeletal muscle.

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Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

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Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging

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Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity

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Age-Associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training

Koltai, E., Hart, N., Taylor, A. W., Goto, S., Ngo, J. K., Davies, K. J. A., & Radak, Z. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00337.2011 · Cited by 152 · see citing works

Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle

Hütter, E., Skovbro, M., Lener, B., Prats, C., Rabøl, R., Dela, F., & Jansen‐Dürr, P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00282.x · Cited by 149 · see citing works

Alterations in intrinsic mitochondrial function with aging are fiber type‐specific and do not explain differential atrophy between muscles

Picard, M. A., Ritchie, D., Thomas, M. M., Wright, K. J., & Hepple, R. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00745.x · Cited by 145 · see citing works

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

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Effects of physical activity and age on mitochondrial function

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Experimental evidence against the mitochondrial theory of aging A study of isolated human skeletal muscle mitochondria

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Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance

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High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

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Effects of old age on human skeletal muscle energetics during fatiguing contractions with and without blood flow

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