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Cited by 176

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene Family

Brown, Sheryl D., Twells, Rebecca C.J., Hey, Patricia J., Cox, Roger D., Levy, Elaine R., Soderman, Avery R., Metzker, Michael L., Caskey, C.Thomas, Todd, John A., Hess, J.Fred·1998·Biochemical and Biophysical Research Communications
DOI 10.1006/bbrc.1998.9061
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Abstract

A novel member of the low density lipoprotein receptor (LDLR) gene family has been identified and characterized. This gene, termed LDL receptor-related protein 6 (LRP6), encodes a transmembrane protein which has 71% identity and is structurally similar to the protein encoded by LRP5, a proposed candidate gene for type 1 diabetes located on human chromosome 11q13. LRP6 maps to human chromosome 12p11-p13. Mouse Lrp6 encodes a protein that has 98% identity to human LRP6 and maps to chromosome 6. Unlike other members of the LDLR family, LRP6 and LRP5 display a unique pattern of four epidermal growth factor (EGF) and three LDLR repeats in the extracellular domain. The cytoplasmic domain of LRP6 is not similar to other members of the LDLR family, while comparison with LRP5 reveals proline-rich motifs that may mediate protein-protein interactions. Thus, it is likely that LRP6 and LRP5 comprise a new class of the LDLR family.

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Crossref · 10.1006/bbrc.1998.9061

Cites

1 of 1 references verified0 citation errors · 0 not checkable

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Recomputing p-values needs the paper’s full text.

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Claims other papers make about this one

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  • LRP5/6 has four β-propeller/EGF modules and three ligand-binding repeats.

    “LRP5/6 has four ␤-propeller/EGF modules and three ligand-binding repeats (Brown et al., 1998;Kim et al., 1998).”

    From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Brown et al., 1998

  • LRP5 and LRP6 lack the conserved NPXY motif but contain several putative di-leucine and YXX motifs.

    “Unlike other members of the LDLR family, LRP5 and LRP6 lack the conserved NPXY motif but contain several putative di-leucine and YXX (where is a bulky hydrophobic amino acid) motifs (Brown et al., 1998;Kim et al., 1998).”

    From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Brown et al., 1998

Citations

Cites

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Metadata

Authors
Brown, S. D., Twells, R. C. J., Hey, P. J., Cox, R. D., Levy, E. R., Soderman, A. R., Metzker, M. L., Caskey, C. T., Todd, J. A., & Hess, J. F.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1998-07
Volume
248
Issue
3
Pages
879-888
ISSN
0006-291X
DOI
10.1006/bbrc.1998.9061
Cited by
176
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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