The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Modulation of LRP6‐mediated Wnt signaling by molecular chaperone Mesd
Open accessAbstract
LRP6 is a Wnt coreceptor at the cell surface. Here, we report that a specialized molecular chaperone Mesd modulates LRP6‐mediated Wnt signaling and how different LRP6 mutants exhibit differential effects on Wnt signaling. We found that overexpression of increasing amounts of the full‐length LRP6 enhances Wnt signaling in a dose dependent manner only in the presence of a co‐expression of the molecular chaperone Mesd, which promotes LRP6 folding and maturation to the cell surface. We also demonstrated that LRP6 mutant lacking the intracellular domain impedes LRP6 cell surface expression and Wnt signaling in a dominant‐negative fashion by sequestering Mesd from promoting LRP6 folding. Our results present novel mechanisms by which Mesd and LRP6 modulate Wnt signaling.
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Metadata
- Authors
- Li, Y., Lu, W., He, X., & Bu, G.
- Affiliations
- Southern Research Institute (US)
- Boston Children's Hospital (US)
- St. Louis Children's Hospital (US)
- Corresponding author
- Li, Yonghe
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-09-18
- Volume
- 580
- Issue
- 22
- Pages
- 5423-5428
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1973537495
- Cited by
- 25
- References
- 27
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Institute on Aging (AG027924)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- LRP6, Wnt signaling, molecular chaperones, cell surface expression, dominant negative effect, cytoplasmic domain
- MeSH terms
- Cell Line, Humans, Signal Transduction, Gene Expression, Protein Folding, Molecular Chaperones, LDL-Receptor Related Proteins, Wnt Proteins, Low Density Lipoprotein Receptor-Related Protein-6
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