Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

‘Hot spots’ of creatine kinase localization in brain: cerebellum, hippocampus and choroid plexus

Kaldis, P., Hemmer, W., Zanolla, E., Holtzman, D., & Wallimann, T. (2009) · Developmental Neuroscience · doi:10.1159/000111452 · Cited by 99

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598

Creatine and Creatinine Metabolism

Wyss, M., & Kaddurah-Daouk, R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1107 · Cited by 2,950

The Role of Oxidative Stress in Parkinson's Disease

Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883

Oxidative Stress in Neurodegenerative Diseases

Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654

Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease

Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

The NINDS NET-PD Investigators (2006) · Neurology · doi:10.1212/01.wnl.0000201252.57661.e1 · Cited by 453

D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

Tieu, K., Perier, C., Caspersen, C., Teismann, P., Wu, D.-C., Yan, S.-D., Naini, A., Vila, M., Jackson-Lewis, V., Ramasamy, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318797 · Cited by 497

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294

Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0406 · Cited by 293

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

Surmeier, D. J., Guzman, J. N., Sanchez-Padilla, J., & Schumacker, P. T. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.045 · Cited by 236

Bioenergetic approaches for neuroprotection in Parkinson's disease

Beal, M. F. (2003) · Annals of Neurology · doi:10.1002/ana.10479 · Cited by 236

Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity

Sestili, P., Martinelli, C., Bravi, G., Piccoli, G., Curci, R., Battistelli, M., Falcieri, E., Agostini, D., Gioacchini, A. M., & Stocchi, V. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.035 · Cited by 220

Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease: A Randomized Clinical Trial

Kieburtz, K., Tilley, B. C., Elm, J. J., Babcock, D., Hauser, R., Ross, G. W., Augustine, A. H., Augustine, E. U., Aminoff, M. J., Bodis-Wollner, I. G., et al. (2015) · JAMA · doi:10.1001/jama.2015.120 · Cited by 207

Synthesis and transport of creatine in the CNS: Importance for cerebral functions

Béard, E., & Braissant, O. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06935.x · Cited by 192

Cerebral creatine deficiency syndromes: Clinical aspects, treatment and pathophysiology

Stockler, S., Schutz, P. W., & Salomons, G. S. (2007) · Subcellular Biochemistry · doi:10.1007/978-1-4020-6486-9_8 · Cited by 180

Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice

Dedeoglu, A., Kubilus, J. K., Yang, L., Ferrante, K. L., Hersch, S. M., Beal, M. F., & Ferrante, A. R. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01706.x · Cited by 169

Creatine for treating muscle disorders

Kley, R. A., Tarnopolsky, M. A., & Vorgerd, M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004760.pub4 · Cited by 169

Minocycline Enhances MPTP Toxicity to Dopaminergic Neurons

Yang, L., Sugama, S., Chirichigno, J. W., Gregorio, J., Lorenzl, S., Shin, D. H., Browne, S. E., Shimizu, Y., Joh, T. H., Beal, M. F., et al. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10709 · Cited by 158

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation

Safdar, A., Yardley, N. J., Snow, R., Melov, S., & Tarnopolsky, M. A. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00157.2007 · Cited by 149

Mitochondrial contact sites: their role in energy metabolism and apoptosis

Brdiczka, D. G., Zorov, D. B., & Sheu, S.-S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.09.007 · Cited by 150

Prophylactic Creatine Administration Mediates Neuroprotection in Cerebral Ischemia in Mice

Zhu, S., Li, M., Figueroa, B. E., Liu, A., Stavrovskaya, I. G., Pasinelli, P., Beal, M. F., Brown, R. H., Kristal, B. S., Ferrante, R. J., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1278-04.2004 · Cited by 138

Pharmacokinetics of the Dietary Supplement Creatine

Persky, A. M., Brazeau, G. A., & Hochhaus, G. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342060-00005 · Cited by 132

Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of Stroke

Prass, K., Royl, G., Lindauer, U., Freyer, D., Megow, D., Dirnagl, U., Stöckler-Ipsiroglu, G., Wallimann, T., & Priller, J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600351 · Cited by 128

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Members, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology · doi:10.1007/s00204-017-2133-4 · Cited by 124

Neuroprotection of Creatine Supplementation in Neonatal Rats with Transient Cerebral Hypoxia-Ischemia

Adcock, K. H., Nedelcu, J., Loenneker, T., Martin, E., Wallimann, T., & Wagner, B. P. (2002) · Developmental Neuroscience · doi:10.1159/000069043 · Cited by 97

Creatine for neuroprotection in neurodegenerative disease: end of story?

Bender, A., & Klopstock, T. (2016) · Amino Acids · doi:10.1007/s00726-015-2165-0 · Cited by 96

Beyond muscles: The untapped potential of creatine

Riesberg, L. A., Weed, S. A., McDonald, T. L., Eckerson, J. M., & Drescher, K. M. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2015.12.034 · Cited by 95

Rational therapeutic approaches to progressive supranuclear palsy

Stamelou, M., de Silva, R., Arias-Carrion, O., Boura, E., Hollerhage, M., Oertel, W. H., Muller, U., & Hoglinger, G. U. (2010) · Brain · doi:10.1093/brain/awq115 · Cited by 91

A review of creatine supplementation in age-related diseases: more than a supplement for athletes

Smith, R. N., Agharkar, A. S., & Gonzales, E. B. (2014) · F1000Research · doi:10.12688/f1000research.5218.1 · Cited by 82

Creatine transporter and mitochondrial creatine kinase protein content in myopathies

Tarnopolsky, M. A., Parshad, A., Walzel, B., Schlattner, U., & Wallimann, T. (2001) · Muscle & Nerve · doi:10.1002/mus.1055 · Cited by 80

Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle

Op ‘t Eijnde, B., Richter, E. A., Henquin, J. ‐., Kiens, B., & Hespel, P. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00786.x · Cited by 79

Creatine Diet Supplement for Spinal Cord Injury: Influences on Functional Recovery and Tissue Sparing in Rats

Rabchevsky, A. G., Sullivan, P. G., Fugaccia, I., & Scheff, S. W. (2003) · Journal of Neurotrauma · doi:10.1089/089771503322144572 · Cited by 70

Potential benefits of creatine monohydrate supplementation in the elderly

Tarnopolsky, M. A. (2000) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200011000-00013 · Cited by 65

Creatine and Glycerol Hyperhydration in Trained Subjects before Exercise in the Heat

Easton, C., Turner, S., & Pitsiladis, Y. P. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.1.70 · Cited by 65

Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease

Balestrino, M., Sarocchi, M., Adriano, E., & Spallarossa, P. (2016) · Amino Acids · doi:10.1007/s00726-016-2173-8 · Cited by 60

Therapeutic use of creatine in brain or heart ischemia: Available data and future perspectives

Perasso, L., Spallarossa, P., Gandolfo, C., Ruggeri, P., & Balestrino, M. (2013) · Medicinal Research Reviews · doi:10.1002/med.20255 · Cited by 43

Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3

Duarte‐Silva, S., Neves‐Carvalho, A., Soares‐Cunha, C., Silva, J. M., Teixeira‐Castro, A., Vieira, R., Silva‐Fernandes, A., & Maciel, P. (2018) · Movement Disorders · doi:10.1002/mds.27292 · Cited by 34

Chronic dietary creatine enhances hippocampal-dependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB

Snow, W. M., Cadonic, C., Cortes-Perez, C., Roy Chowdhury, S. K., Djordjevic, J., Thomson, E., Bernstein, M. J., Suh, M., Fernyhough, P., & Albensi, B. C. (2018) · Learning & Memory · doi:10.1101/lm.046284.117 · Cited by 31

Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice

Allah Yar, R., Akbar, A., & Iqbal, F. (2015) · Brain Research · doi:10.1016/j.brainres.2014.11.017 · Cited by 30

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

Alraddadi, E., Lillico, R., Vennerstrom, J., Lakowski, T., & Miller, D. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010031 · Cited by 30

Creatine Monohydrate Supplementation Does not Improve Functional Recovery after total Knee Arthroplasty

Roy, B. D., de Beer, J., Harvey, D., & Tarnopolsky, M. A. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2005.01.005 · Cited by 28

Co-administration of creatine plus pyruvate prevents the effects of phenylalanine administration to female rats during pregnancy and lactation on enzymes activity of energy metabolism in cerebral cortex and hippocampus of the offspring

Bortoluzzi, V. T., de Franceschi, I. D., Rieger, E., & Wannmacher, C. M. D. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1353-8 · Cited by 19

A potential role for creatine in drug abuse?

D’Anci, K. E., Allen, P. J., & Kanarek, R. B. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8176-2 · Cited by 9