Cited by 504Endometriosis Research and TreatmentEffects and risks of endocrine disrupting chemicalsToxic Organic Pollutants Impact

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Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Rier, S·1993·Fundamental and Applied Toxicology

DOI 10.1006/faat.1993.1119

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Abstract

The incidence of the reproductive disease endometriosis was determined in a colony of rhesus monkeys chronically exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) for a period of 4 years. Ten years after termination of dioxin treatment, the presence of endometriosis was documented by surgical laparoscopy and the severity of disease was assessed. The incidence of endometriosis was directly correlated with dioxin exposure and the severity of disease was dependent upon the dose administered (p < 0.001). Three of 7 animals exposed to 5 ppt dioxin (43%) and 5 of 7 animals exposed to 25 ppt dioxin (71%) had moderate to severe endometriosis. In contrast, the frequency of disease in the control group was 33%, similar to an overall prevalence of 30% in 304 rhesus monkeys housed at The Harlow Primate Center with no dioxin exposure. This 15-year study indicates that latent female reproductive abnormalities may be associated with dioxin exposure in the rhesus. Therefore, the effects of this toxin may be more diverse than previously recognized.

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Self-citation
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How can chemical compounds alter human fertility?
Massaad, C., Entezami, F., Massaad-Massade, L., Benahmed, M., Olivennes, F. J., Barouki, R., & Hamamah, S. (2002) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(01)00441-9 · Cited by 60
Hospitals and plastics. Dioxin prevention and medical waste incinerators.
Thornton, J. W., McCally, M., Orris, P., & Weinberg, J. (1996) · PubMed Central · Cited by 58
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“Endometriosis was found to be directly linked to dioxin exposure, and the severity of the condition was determined by the dose given [65].”
Background
The Potential Role of Exposure to Environmental Toxicants in the Pathophysiology of Endometriosis
Rier, S. E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02781.x · Cited by 58
Self-citation
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Nakago, S. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.11.1079 · Cited by 58
Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice
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Background
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Background
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Koninckx, P. R. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000052859 · Cited by 56
Effect of TCDD Exposure on CYP1A1 and CYP1B1 Expression in Explant Cultures of Human Endometrium
Bofinger, D. P. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.2.299 · Cited by 56
“, 1983) and dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) (Rier et al., 1993).”
Endometriosis: The way forward
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Niskar, A. S., Needham, L. L., Rubin, C., Turner, W. E., Martin, C. A., Patterson, D. G., Hasty, L. A., Wong, L.-Y., & Marcus, M. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.10.005 · Cited by 56
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Guo, S. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.10.002 · Cited by 55
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Background
Toxicological consequences of aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part 2. Reproduction and infant findings
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The reproductive toxicology of Great Lakes contaminants.
Foster, W. G. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s963 · Cited by 55
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“An autoimmune aetiology has also been implied [13,14], and exposure to environmental toxins has been suggested although results are not consistent [15,16].”
Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma
Ploteau, S., Cano-Sancho, G., Volteau, C., Legrand, A., Vénisseau, A., Vaccher, V., Marchand, P., Bizec, B. L., & Antignac, J. (2017) · Environment International · doi:10.1016/j.envint.2017.08.019 · Cited by 55
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Gilbertson, M., & Brophy, J. T. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s6827 · Cited by 54
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Axelrod, D., Burns, K., Davis, D. L., & von Larebeke, N. (2004) · International Journal of Occupational and Environmental Health · doi:10.1179/oeh.2004.10.3.335 · Cited by 49
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Tricotteaux-Zarqaoui, S., Lahimer, M., Diwan, M. A., Corona, A., Candela, P., Cabry, R., Bach, V., Khorsi‐Cauet, H., & Khalifa, M. B. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1466967 · Cited by 54
The aromatic hydrocarbon receptor, dioxin action, and endocrine homeostasis
Whitlock, J. P. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)90075-2 · Cited by 49
Redefining endometriosis: Endometriosis is an entity with extreme pleiomorphism
Leyendecker, G. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.4 · Cited by 49
Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1
Koch, D. C., Jang, H. S., O’Donnell, E. F., Punj, S., Kopparapu, P., Bisson, W. H., Kerkvliet, N. I., & Kolluri, S. K. (2015) · Oncogene · doi:10.1038/onc.2015.55 · Cited by 51
Polychlorinated biphenyls and its potential role in endometriosis
Yao, M., Hu, T., Wang, Y., Du, Y., Hu, C., & Wu, R. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.06.088 · Cited by 47
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“, 1993) that rhesus monkeys exposed daily for 4 years to 5 or 25 parts per trillion (ppt) of dioxin, develop endometriosis, with incidence and severity proportional to dose (Rier et al., 1993).”
BackgroundResultInfluential
Incidence of endocrine disease among residents of New York areas of concern.
Carpenter, D. O., Shen, Y., Nguyen, T. Q., Le, L., & Lininger, L. L. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s6845 · Cited by 47
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“The occurrence of endometriosis in female Rhesus monkey (Rier et al., 1993) after chronic low dose exposure to TCDD has been one of the critical outcomes for the de®nition of the TDI in the 1998 WHO consultation (WHO, 1998).”
BackgroundResult
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Authors: Rier, S.
Affiliations: Rush University Medical Center (US)
Corresponding author: Rier, S
ORCID: Rier, S
Venue: Fundamental and Applied Toxicology
Publisher: Elsevier BV
Published: 1993-11
Volume: 21
Issue: 4
Pages: 433-441
ISSN: 0272-0590 (ISSN-L)
DOI: 10.1006/faat.1993.1119
OpenAlex: W2121492292
Cited by: 502
References: 0
Citations by year: 2026: 2 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 19
FWCI: 13.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Fundamental and Applied Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: endometriosis, 2,3,7,8-tetrachlorodibenzo-p-dioxin, dioxins, rhesus monkeys, long-term exposure, dose-response relationship, endometriosis severity, chronic toxicity
MeSH terms: Polychlorinated Dibenzodioxins, Animals, Endometriosis, Female, Macaca mulatta, Monkey Diseases

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Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

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