Actions of testosterone in prepubertal and postpubertal male hamsters: dissociation of effects on reproductive behavior and brain androgen receptor immunoreactivity
Abstract
This study was conducted to determine whether there is a increase in responsiveness to the activating effects of testosterone on male reproductive behavior during puberty in male golden hamsters and whether responsiveness to behavioral actions of testosterone is correlated with the ability of testosterone to upregulate brain androgen receptor immunoreactivity (AR-ir). Sexually naive male hamsters were castrated at 21 or 42 days of age and implanted subcutaneously with a pellet containing 0, 2.5, or 5 mg of testosterone. One week later, males were given a 10-min mating test with a receptive female. Animals were euthanized 1 hr after the behavioral test, and blood samples and brains were collected. Plasma testosterone levels were equivalent in prepubertal and adult males that had been administered the same dose of testosterone. However, adult males exhibited more mounts, intromissions, and ejaculations than prepubertal males, demonstrating that postpubertal males are more responsive than prepubertal males to the effects of testosterone on sexual behavior. In both age groups, testosterone increased the number of AR-ir cells per unit area in several brain regions involved in male sexual behavior, including the medial preoptic nucleus (MPN), medial amygdala, posteromedial bed nucleus of the stria terminalis, and magnocellular preoptic nucleus (MPNmag). Surprisingly, testosterone increased AR-ir in the latter three regions to a greater extent in prepubertal males than in adults. Thus, prepubertal males are more responsive to the effects of testosterone on AR-ir in these regions. In a separate experiment, a pubertal increase in the number of AR-ir cells per unit area was found in both the MPN and MPNmag of intact male hamsters. These results indicate that a testosterone-dependent increase in brain AR during puberty may be necessary, but is not sufficient, to induce an increase in behavioral responsiveness to testosterone.
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Recent studies demonstrate that organizational changes occur during adolescence and may be critical for activational changes to take place.
“recent studies have demonstrated that there are organizational changes occurring during adolescence as well, and, moreover, that these organizational changes may be critical for activational changes to take place”
From Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking (2013) · cites this paper as Meek et al., 1997
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Self-citation
- Authors
- Meek, L. R., Romeo, R. D., Novak, C. M., & Sisk, C. L.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Sisk, Cheryl L.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 31
- Issue
- 1
- Pages
- 75-88
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2035916440
- Cited by
- 91
- References
- 45
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 4 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 7
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kementerian Pendidikan Nasional
- National Institutes of Health (1k04hd000950-01)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-26483, R01HD026483, HD-00950)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- testosterone, puberty, male reproductive behavior, androgen receptor, prepubertal males, golden hamster, medial preoptic nucleus, magnocellular preoptic nucleus, medial amygdala, bed nucleus of the stria terminalis, castration, testosterone implants, sexual behavior
- MeSH terms
- Animals, Brain, Female, Cricetinae, Immunohistochemistry, Male, Receptors, Androgen, Sexual Behavior, Animal, Sexual Maturation, Testosterone
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