Cited by 164Alzheimer's disease research and treatmentsCell death mechanisms and regulationNeuroinflammation and Neurodegeneration Mechanisms

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β-Amyloid Induces Local Neurite Degeneration in Cultured Hippocampal Neurons: Evidence for Neuritic Apoptosis

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Ivins, Kathryn J., Bui, Elizabeth T.N., Cotman, Carl W.·1998·Neurobiology of Disease

DOI 10.1006/nbdi.1998.0228

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Abstract

Many apoptotic insults, including beta-amyloid, cause neuritic degeneration. The possibility that apoptotic insults act directly on neurites was investigated in experiments using compartmented cultures of hippocampal neurons. Neurites in modified Campenot chambers displayed morphological signs of degeneration, including beading or blebbing, when exposed to beta-amyloid. At short time points neurite degeneration was limited to the distal portions of neurites directly exposed to beta-amyloid. Furthermore, annexin V binding detected extracellular exposure of phosphatidylserine in portions of neurites directly exposed to apoptotic insults. Pretreatment of the cultures with zVAD-fmk blocked annexin V binding induced by beta-amyloid and concanavalin A, suggesting that caspase activity was required. Caspase activation was also visualized in neurites locally exposed to apoptotic insults. Together these results show that apoptotic insults cause local neurite degeneration which displays morphological and biochemical characteristics of apoptosis and suggest that neurite degeneration may use mechanisms common to apoptosis.

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Authors: Ivins, K. J., Bui, E. T. N., & Cotman, C. W.
Affiliations: University of California, Irvine (US)
Corresponding author: Ivins, Kathryn J.
ORCID: Cotman, Carl W.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 1998-11
Volume: 5
Issue: 5
Pages: 365-378
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1006/nbdi.1998.0228
OpenAlex: W2012008959
Cited by: 164
References: 58
Citations by year: 2025: 3 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 8 · 2013: 7 · 2012: 8
FWCI: 5.52
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (5r01ag013007-05)
University of California, Irvine
National Institute on Aging (T32 AG00096, R01-AG13007)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, neurite degeneration, hippocampal neurons, phosphatidylserine exposure, annexin V binding, caspase activation, z-VAD-fmk, concanavalin A, Alzheimer's disease
MeSH terms: Animals, Cells, Cultured, Hippocampus, Nerve Degeneration, Neurons, Time Factors, Amyloid beta-Peptides, Neurites, Apoptosis, Annexin A5, Caspases, Rats

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β-Amyloid Induces Local Neurite Degeneration in Cultured Hippocampal Neurons: Evidence for Neuritic Apoptosis

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