Cited by 817Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

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How Many Subjects Constitute a Study?

Friston, Karl J., Holmes, Andrew P., Worsley, Keith J.·1999·NeuroImage

DOI 10.1006/nimg.1999.0439

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Abstract

In fMRI there are two classes of inference: one aims to make a comment about the "typical" characteristics of a population, and the other about "average" characteristics. The first pertains to studies of normal subjects that try to identify some qualitative aspect of normal functional anatomy. The second class necessarily applies to clinical neuroscience studies that want to make an inference about quantitative differences of a regionally specific nature. The first class of inferences is adequately serviced by conjunction analyses and fixed-effects models with relatively small numbers of subjects. The second requires random-effect analyses and larger cohorts.

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Method
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Method
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Method
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“続いて各被験者から得た推定パラメータ値で構成される画像を用いて,被験者間の分散を考慮に入れた変動効果モデルによるグループ解析を行った[10].”
Background
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Lee, I.-S., Lee, J., & Kwon, Y. (2009) · Journal of The Korean Association For Science Education
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Authors: Friston, K. J., Holmes, A. P., & Worsley, K. J.
Affiliations: National Hospital for Neurology and Neurosurgery (GB)
ORCID: Friston, Karl J.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 1999-07
Volume: 10
Issue: 1
Pages: 1-5
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1006/nimg.1999.0439
OpenAlex: W1966363088
Cited by: 814
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 17 · 2019: 13 · 2018: 10 · 2017: 15 · 2016: 31 · 2015: 27 · 2014: 22 · 2013: 35 · 2012: 30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: sample size, functional MRI, statistical inference, population inference, fixed effects model, random effects models, conjunction analysis, clinical neuroscience, functional anatomy, cohort size
MeSH terms: Data Interpretation, Statistical, Humans, Magnetic Resonance Imaging, Research Design, Models, Statistical, Cohort Studies, Patient Selection

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