Cited by 542Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesNeurological disorders and treatments

Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans

Lehéricy, Stéphane, Ducros, Mathieu, Van De Moortele, Pierre‐François, Francois, Chantal, Thivard, Lionel, Poupon, Cyril, Swindale, Nick, Ugurbil, Kamil +1 more·2004·Annals of Neurology

Abstract

A landmark of corticostriatal connectivity in nonhuman primates is that cortical connections are organized into a set of discrete circuits. Each circuit is assumed to perform distinct behavioral functions. In animals, most connectivity studies are performed using invasive tracing methods, which are nonapplicable in humans. To test the proposal that corticostriatal connections are organized as multiple circuits in humans, we used diffusion tensor imaging axonal tracking, a new magnetic resonance technique that allows demonstration of fiber tracts in a noninvasive manner. Diffusion tensor imaging–based fiber tracking showed that the posterior (sensorimotor), anterior (associative), and ventral (limbic) compartments of the human striatum have specific connections with the cortex, and particularly the frontal lobes. These results provide the first direct demonstration of distinct corticostriatal connections in humans.

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Crossref · 10.1002/ana.20030

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  • Structural connectivity imaging techniques in humans have begun to find support for the general organization of the corticostriatal circuitry described.

    “The majority of these connectivity studies utilize neuroanatomical tracing in non-human species, but structural connectivity imaging techniques in humans have begun to find support for the general organization of the corticostriatal circuitry described here 9.”

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Authors
Lehéricy, S., Ducros, M., Van De Moortele, P., Francois, C., Thivard, L., Poupon, C., Swindale, N., Ugurbil, K., & Kim, D.
Affiliations
Boston University (US)
Corresponding author
Lehéricy, Stéphane
Venue
Annals of Neurology
Publisher
Wiley
Published
2004-03-22
Volume
55
Issue
4
Pages
522-529
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2172252744
Cited by
542
References
32
Citations by year
2026: 8 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 22 · 2020: 23 · 2019: 32 · 2018: 27 · 2017: 29 · 2016: 33 · 2015: 39 · 2014: 26 · 2013: 43 · 2012: 41
FWCI
16.59
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • NIH (BTRR P41-RR008079)
  • Keck Foundation
  • Human Frontiers Science Program
  • Inciting Joint Actions Committee (AC1-6503H)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
corticostriatal circuits, corticostriatal connectivity, diffusion tensor imaging, tractography, human striatum, sensorimotor striatum, associative striatum, limbic striatum
MeSH terms
Adult, Cerebral Cortex, Corpus Striatum, Female, Humans, Male, Nerve Fibers, Nerve Net, Diffusion Magnetic Resonance Imaging

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