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Human Papillomavirus Types 16 E6 and E7 Contribute Differently to Carcinogenesis

Song, Shiyu, Liem, Amy, Miller, James A., Lambert, Paul F.·2000·Virology
DOI 10.1006/viro.1999.0106
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Abstract

High-risk human papillomaviruses (HPVs) are etiologically implicated in human cervical cancer. Two viral genes, E6 and E7, are commonly found expressed in these cancer cells. We have previously shown that mice transgenic for the HPV-16 E6 gene or E7 gene, in which the E6 or E7 was expressed in the basal layer of epithelia, developed skin tumors. The spectrum of tumors derived from E6 and E7 mice differed, however; although most tumors derived from the E7-transgenic mice were benign, the majority of the tumors from the E6-transgenic mice were malignant. These findings led us to hypothesize that E6 and E7 play different roles in carcinogenesis. To assess at what stages in carcinogenesis E6 and E7 act, we treated the skin of K14E6- and K14E7-transgenic mice with chemical carcinogens known to contribute to distinct stages in carcinogenesis. Both E6 and E7 were found to synergize with chemical carcinogens in causing tumor formation. E6 was found to act weakly at the promotion stage of carcinogenesis in the formation of benign tumors but strongly at the progression stage which involves the malignant conversion of benign tumors. In contrast, E7 primarily affected the promotion stage of carcinogenesis. These results provide direct evidence that E6 and E7 contribute differently to carcinogenesis; E7 promotes the formation of benign tumors, and E6 acts primarily to accelerate progression of these benign tumors to the malignant stage. Consistent with this model, we found E6 and E7 to co…

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  1. Arbeit, 1993, Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs, Am. J. Pathol., 142, 1187
  2. Baker, 1987, Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines, J. Virol., 61, 962, 10.1128/jvi.61.4.962-971.1987 · DOI
  3. Ball, 1994, Ras mutations in human melanoma: A marker of malignant progression, J. Invest. Dermatol., 102, 285, 10.1111/1523-1747.ep12371783 · DOI
  4. Boutwell, 1989, Model systems for defining initiation, promotion, and progression of skin neoplasms, Prog. Clin. Biol. Res., 298, 3
  5. Brown, 1986, v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis, Cell, 46, 447, 10.1016/0092-8674(86)90665-3 · DOI
  6. Chakravarti, 1995, Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites, Proc. Natl. Acad. Sci. USA, 92, 10422, 10.1073/pnas.92.22.10422 · DOI
  7. Chen, 1995, Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein, Science, 269, 529, 10.1126/science.7624774 · DOI · Paper page
  8. Choo, 1987, Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames, Virology, 161, 259, 10.1016/0042-6822(87)90195-4 · DOI
  9. Cooper, 1992, Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma, J. Clin. Pathol., 45, 382, 10.1136/jcp.45.5.382 · DOI
  10. Crook, 1988, Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells, Proc. Natl. Acad. Sci. USA, 85, 8820, 10.1073/pnas.85.23.8820 · DOI
  11. Dalal, 1996, Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells, J. Virol., 70, 638, 10.1128/jvi.70.2.683-688.1996 · DOI · Paper page
  12. Daling, 1992, Cigarette smoking and the risk of anogenital cancer, Am. J. Epidemiol., 135, 180, 10.1093/oxfordjournals.aje.a116270 · DOI
  13. Daniel, 1997, The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions, J. Gen. Virol., 78, 1095, 10.1099/0022-1317-78-5-1095 · DOI
  14. Drinkwater, 1990, Experimental models and biological mechanisms for tumor promotion, Cancer Cells, 2, 8
  15. Dyson, 1992, Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins, J. Virol., 66, 6893, 10.1128/jvi.66.12.6893-6902.1992 · DOI · Paper page
  16. Gao, 1999, The E6 oncoprotein of high risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation, Mol. Cell. Biol., 19, 733, 10.1128/MCB.19.1.733 · DOI
  17. Greenhalgh, 1994, Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas, Cell Growth Differ., 5, 667
  18. Griep, 1993, Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation, J. Virol., 67, 1373, 10.1128/jvi.67.3.1373-1384.1993 · DOI
  19. Gulliver, 1997, Both the CR1 and CR2 domains of HPV-16 E7 are required for the induction of epidermal hyperplasia and tumor formation in transgenic mice, J. Virol., 71, 5905, 10.1128/jvi.71.8.5905-5914.1997 · DOI · Paper page
  20. Herber, 1996, Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene, J. Virol., 70, 1873, 10.1128/jvi.70.3.1873-1881.1996 · DOI
  21. Iglesias, 1998, Human papillomavirus type 16 E7 protein sensitizes cervical keratinocytes to apoptosis and release of interleukin-1alpha, Oncogene, 17, 1195, 10.1038/sj.onc.1202054 · DOI
  22. Imamoto, 1993, Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice, Carcinogenesis, 14, 719, 10.1093/carcin/14.4.719 · DOI
  23. Jones, 1997, Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis, Virology, 239, 97, 10.1006/viro.1997.8851 · DOI · Paper page
  24. Kalogeraki, 1996, Cigarette smoking as a risk factor for intraepithelial lesion of the cervix uteri, In Vivo, 10, 613
  25. Kemp, 1993, Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors, Cell, 74, 813, 10.1016/0092-8674(93)90461-X · DOI
  26. Kiyono, 1997, Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein, Proc. Natl. Acad. Sci. USA, 94, 11612, 10.1073/pnas.94.21.11612 · DOI · Paper page
  27. Klingelhutz, 1996, Telomerase activation by the E6 gene product of human papillomavirus type 16, Nature, 380, 79, 10.1038/380079a0 · DOI · Paper page
  28. Lambert, 1993, Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice, Proc. Natl. Acad. Sci. USA, 90, 5583, 10.1073/pnas.90.12.5583 · DOI
  29. Lee, 1997, Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein, Proc. Natl. Acad. Sci. USA, 94, 6670, 10.1073/pnas.94.13.6670 · DOI · Paper page
  30. Liu, 1995, The expression levels of the human papillomavirus type 16 E7 correlate with its transforming potential, Virology, 207, 260, 10.1006/viro.1995.1075 · DOI
  31. Liu, 1994, The E6 gene of human papillomavirus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras, Virology, 201, 388, 10.1006/viro.1994.1306 · DOI · Paper page
  32. McIntyre, 1996, Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107, Virology, 215, 73, 10.1006/viro.1996.0008 · DOI
  33. Munger, 1989, The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes, J. Virol., 63, 4417, 10.1128/jvi.63.10.4417-4421.1989 · DOI · Paper page
  34. Nakagawa, 1995, Mutational analysis of human papillomavirus type 16 E6 protein: transforming function for human cells and degradation of p53 in vitro, Virology, 212, 535, 10.1006/viro.1995.1511 · DOI
  35. Nakao, 1997, Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation, Br. J. Cancer, 75, 1410, 10.1038/bjc.1997.243 · DOI
  36. Ordman, 1985, 12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion, Cancer Lett., 29, 79, 10.1016/0304-3835(85)90126-0 · DOI
  37. Pan, 1994, Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development, Genes Dev., 8, 1285, 10.1101/gad.8.11.1285 · DOI
  38. Pan, 1995, Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development, Genes Dev., 9, 2157, 10.1101/gad.9.17.2157 · DOI
  39. Pence, 1987, Murine epidermal xanthine oxidase activity: Correlation with degree of hyperplasia induced by tumor promoters, Cancer Res., 47, 6388
  40. Phelps, 1988, The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A, Cell, 53, 539, 10.1016/0092-8674(88)90570-3 · DOI · Paper page
  41. Prokopczyk, 1997, Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers, J. Natl. Cancer Inst., 89, 868, 10.1093/jnci/89.12.868 · DOI
  42. Quintanilla, 1986, Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis, Nature, 322, 78, 10.1038/322078a0 · DOI
  43. Reznikoff, 1994, Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells, Genes Dev., 8, 2227, 10.1101/gad.8.18.2227 · DOI
  44. Scheffner, 1993, The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53, Cell, 75, 495, 10.1016/0092-8674(93)90384-3 · DOI · Paper page
  45. Scheffner, 1990, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53, Cell, 63, 1129, 10.1016/0092-8674(90)90409-8 · DOI · Paper page
  46. Sherman, 1997, Inhibition of serum- and calcium-induced differentiation of human keratinocytes by HPV16 E6 oncoprotein: Role of p53 inactivation, Virology, 237, 296, 10.1006/viro.1997.8778 · DOI
  47. Sherman, 1996, Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16, J. Virol., 70, 3269, 10.1128/jvi.70.5.3269-3279.1996 · DOI
  48. Shin, 1994, Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal human oral keratinocytes, Mol. Carcinogen., 9, 76, 10.1002/mc.2940090205 · DOI
  49. Snijders, 1998, Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: Strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA, Cancer Res., 58, 3812
  50. Song, 1998, Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways, Proc. Natl. Acad. Sci. USA, 95, 2290, 10.1073/pnas.95.5.2290 · DOI
  51. Song, 1999, Human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals, J. Virol., 73, 5887, 10.1128/JVI.73.7.5887-5893.1999 · DOI
  52. Stoppler, 1998, The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis, Oncogene, 17, 1207, 10.1038/sj.onc.1202053 · DOI
  53. Storey, 1993, Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells, Oncogene, 8, 919
  54. Tong, 1997, The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton, Proc. Natl. Acad. Sci. USA, 94, 4412, 10.1073/pnas.94.9.4412 · DOI
  55. Watanabe, 1990, Mutational analysis of human papillomavirus type 16 E7 functions, J. Virol., 64, 207, 10.1128/jvi.64.1.207-214.1990 · DOI
  56. Werness, 1990, Association of human papillomavirus types 16 and 18 E6 proteins with p53, Science, 248, 76, 10.1126/science.2157286 · DOI · Paper page
  57. White, 1994, Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins, Genes Dev., 8, 666, 10.1101/gad.8.6.666 · DOI
  58. Zerfass, 1995, Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation, J. Virol., 69, 6389, 10.1128/jvi.69.10.6389-6399.1995 · DOI · Paper page
  59. Zerfass-Thome, 1996, Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein, Oncogene, 13, 2323
  60. zur Hausen, 1996, Papillomavirus infections–a major cause of human cancers, Biochim. Biophys. Acta, 1288, F55

Cited by

Metadata

Authors
Song, S., Liem, A., Miller, J. A., & Lambert, P. F.
Venue
Virology
Publisher
Elsevier BV
Published
2000-02
Volume
267
Issue
2
Pages
141-150
ISSN
0042-6822
DOI
10.1006/viro.1999.0106
Cited by
160
References
3
Language
en
Licence

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